SETD1B

Histone-lysine N-methyltransferase SETD1B

2008 amino acids

Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (By similarity).

Belongs to the class V-like SAM-binding methyltransferase superfamily.

223.085 kDa

MSFREIKAGEKAKHPEDHGKKQSSSWINGMENSTQASTSVEKRNHHWRSYKLIIDPALKKGQHKLYRYDGQHFSMPNSGIAPVDCVRDPRIGRIWTKTKELELSVPKFKIDEFYVGPVPPKQVTFAKLNDNIRENFLTDMCKKYGEVEEVEILYNPKNKKHLGIAKVIFATVKGAREAVQHLHNTSVMGNIIHVELDTKGETRMRFYELLVNGLYTPQTLPVGTEQDASPTVNETLQLTDSLKRLKDSNLSSVGSSVTPNSSTPFSHDTAYSSCRQDTPNSFSQFTPQSQGTPHTPRLGTPFSQDSTYSSRQTTPVYHFGQDSGYKHRRHETKFTDAYNRRPGGHHYVHNSPGVFRGTEHQFSTFKSHQQEPVQFSHTPPLSHSSSSSYKSAFSPYQAPAVFPQSEEQPFAQTSREAEYRRPAPPPAEMVVESSAATSADFAPVKEKPEEPPPLPDSNSAPEPSAPSFSQTPERSETPGTPTMESEMQHNSLDSRIEMLLKEQRTKLPFLNEHDSDNEVRMEGSPISSSSSQLSPIPMYGSNSQPGYRAQTPSSRPSSTGLEDISPTPLPDSDDDEPIPGTASLNQNSRGTSEASMTPIDQLNRASKVETLEVKEMVPGDQTPTSEKMDESQHSSGEDMEISDDEMNSAPITSAECAKTIVVNSSVSNAAVMAPSIPPLPPPPGFPPLPPPPPPPPQPAFPMPPPLPPPPPPTHPAVTVPPPPLPAPPGVPPPHILPPLPPFHPGMFPVMQVDMISVLGNHWGGMPMSFQMQTQMLSRMMQAQNTYQYPPFMGGRMQFVNLPPYRPFSMGAARGRGQQWPPLPKFDPSVPPPGYEPKKEDPHKATVDGVLLVIVKELKAIMKRDLNRKMVEVVAFRAFDDWWDKKERLAKASLTPVKSGGELEEKPKPKDRITSCLLENWNKGEGLGYEGIGLGIGLRGAIRLPSFKVKRKEPPEAASAGDQKRIRPSTSVDDEDEESERDRDASDTTSDLSKKDAEAVGLRRRPARPLELDSEGEEGDETSGKEEESSSEKEEEQEEEGGLVKAAPGKEEEEDEDDEEDEDDDEDEEDEEDYEETGVETSDKEEEQDSEEEDAASPSSSKAEVESSDESEDSSEFESSSDSDEDDDEEEEEEEDEEEEEEEEVAEDQDREAMVAETEHEPASHELPDDKRETILELYPVDYMDATGLGLSEPALVEKDEGMEEVKAEESECDQVPEESIAAETLKQLVMERDQETKLALSPICRPVEEPEPIVMLEPEVQECPKPESQDEAGTVCLSTPVAVFGEARPSKSSFFSKSDDSCLETHVKTKLPSAVEEEDRLPRTPGREVVVHSETDILLLPAHKVPSSTVPLPSTPGKEESVVPPEKFPEQLMVTKTSIEEEIPRTPGRDILAKSSHPLGKSQSTDTVPATPGSDAPLTGSSLTLSSPQVPGSPFSYPSQSPGINSGIPRTPGRDFNFTPTFPEAGATIPCLLSGKKQSEDDLDEKPFKEPLGASLTISMNSVPSPIPFASPTQADFRTDMGLPPNEPIPIAALPCIPGDGRMPIEECKAEVKSVLLSPEAPVGASILPPPPPHSVLPKRRPGRPRRSPPSVLSLDMYSGKTIEPPPVPVALVESAMSKELLSAHPDAFYGLKDPEAVTLDFRNDSFHEKIAAETVAEKLPFKELENQWNEDFKEEEAHAKPKRQWRRQKKSPEHLPVIPSPEYSPPQPQFRPRSEFEEMTILYDIWNGGIDEEDIKFMCITYDRLLQQDNGMDWLNDTLWVFHPSTSFSTPKKKKRDDGMREHVTGCARSEGYYKIDKKDKLKYLNNSRAFAEEPPADTQGMSIPAQPHASTRAGSERRSEQRRLLSSFTGSCDSDLLKFNQLKFRKKKLKFCKSHIHDWGLFAMEPIAADEMVIEYVGQNIRQVIADMREKRYEDEGIGSSYMFRVDHDTIIDATKCGNFARFINHSCNPNCYAKVITVESQKKIVIYSKQHINVNEEITYDYKFPIEDVKIPCLCGSENCRGTLN

Setd1b

Histone-lysine N-methyltransferase SETD1B

1985 amino acids

Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression (By similarity).

Belongs to the class V-like SAM-binding methyltransferase superfamily.

215.352 kDa

MENSHPHHHHQQPPPQPGPSGERRNHHWRSYKLMIDPALKKGHHKLYRYDGQHFSLAMSSNRPVEIVEDPRVVGIWTKNKELELSVPKFKIDEFYVGPVPPKQVTFAKLNDNVRENFLRDMCKKYGEVEEVEILYNPKTKKHLGIAKVVFATVRGAKEAVQHLHSTSVMGNIIHVELDTKGETRMRFYELLVTGRYTPQTLPVGELDAISPIVSETLQLSDALKRLKDGSLSAGCGSGSSSVTPNSGGTPFSQDTAYSSCRLDTPNSYGQGTPITPRLGTPFSQDSSYSSRQPTPSYLFSQDPTATFKARRHESKFTDAYNRRHEHHYVHNSAVAGATAPFRGSSDLSFGTVGSSGTPFKAQSQDATTFAHTPPPAQTATASGFKSAFSPYQTPAPPFPPPPEEPTATAAFGSRDSGEFRRAPAPPPLPPAEPPAKEKPGTPPGPPPPDSNSMELGGRPTFGWSPEPCDSPGTPTLESSPAGPEKPHDSLDSRIEMLLKEQRTKLPFLREQDSDTEIQMEGSPISSSSSQLSPLSHFGTNSQPGFRGPSPPSSRPSSTGLEDISPTPLPDSDEDEDLGLGLGPRPPPEPGPPDPMGLLGQTAEVDLDLAGDRTPTSERMDEGQQSSGEDMEISDDEMPSAPITSADCPKPMVVTPGAGAVAAPNVLAPNLPLPPPPGFPPLPPPPPPPPPQPGFPMPPPLPPPPPPPPPAHPAVTVPPPPLPAPPGVPPPPILPPLPPFPPGLFPVMQVDMSHVLGGQWGGMPMSFQMQTQMLSRLMTGQGACPYPPFMAAAAAAASAGLQFVNLPPYRSPFSLSNSGPGRGQHWPPLPKFDPSVPPPGYIPRQEDPHKATVDGVLLVVLKELKAIMKRDLNRKMVEVVAFRAFDEWWDKKERMAKASLTPVKSGEHKDEDRPKPKDRIASCLLESWGKGEGLGYEGLGLGIGLRGAIRLPSFKVKRKEPPDTASSGDQKRLRPSTSVDEEDEESERERDRDIADAPCELTKRDPKSVGVRRRPGRPLELDSGGEEDEKESLSASSSSSASSSSGSSTTSPSSSASDKEEEDRESTEEEEEEEEEEAEEEEEEGPRSRISSPSSSSSSDKDDEDDNEADSDGQIDSDIDDQGAPLSEASEKDNGDSEEEETESITTSKAPAESSSSSSESSGSSEFESSSESESSSSSSEDEEEMTVPGVEEEEEEEEEEEKETAMAAATVVAMAEESMPPAGGQDFEQDRAEVPLGPRGPMRESLGTEEEVDIEAEDEVPEMQAPELEEPPLPMGARKLEGSPEPPEEPGPNTQGDMLLSPELPARETEEAQLPSPPEHGPESDLDMEPEPPPMLSLPLQPPLPPPRLLRPPSPPPEPETPEPPKPPVPLEPPPEDHPPRTPGLCGSLAKSQSTETVPATPGGEPPLSGSSSGLSLSSPQVPGSPFSYPSPSPGLSSGGLPRTPGRDFSFTPTFPEPSGPLLLPVCPLPTGRRDERTGPLASPVLLETGLPLPLPLPLPLPLALPVPVLRAQPRPPPQLPPLLPATLAPCPTPIKRKPGRPRRSPPSMLSLDGPLVRPPPGPALGRDLLLLPGQPPAPIFPSAHDPRAVTLDFRNTGIPAPPPPLPPQPPPPPPPPPVESTKLPFKELDNQWPSEAIPPGPRRDEVTEEYVDLAKVRGPWRRPPKKRHEDLVAPSASPEPSPPQPLFRPRSEFEEMTILYDIWNGGIDEEDIRFLCVTYERLLQQDNGMDWLNDTLWVYHPSTSLSSAKKKKREDGIREHVTGCARSEGFYTIDKKDKLRYLNSSRASTDEPPMDTQGMSIPAQPHASTRAGSERRSEQRRLLSSFTGSCDSDLLKFNQLKFRKKKLKFCKSHIHDWGLFAMEPIAADEMVIEYVGQNIRQVIADMREKRYEDEGIGSSYMFRVDHDTIIDATKCGNFARFINHSCNPNCYAKVITVESQKKIVIYSKQHINVNEEITYDYKFPIEDVKIPCLCGSENCRGTLN

SETD1B

Histone-lysine N-methyltransferase SETD1B

1966 amino acids

Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro.

Belongs to the class V-like SAM-binding methyltransferase superfamily.

212.803 kDa

MENSHPPHHHHQQPPPQPGPSGERRNHHWRSYKLMIDPALKKGHHKLYRYDGQHFSLAMSSNRPVEIVEDPRVVGIWTKNKELELSVPKFKIDEFYVGPVPPKQVTFAKLNDNIRENFLRDMCKKYGEVEEVEILYNPKTKKHLGIAKVVFATVRGAKDAVQHLHSTSVMGNIIHVELDTKGETRMRFYELLVTGRYTPQTLPVGELDAVSPIVNETLQLSDALKRLKDGGLSAGCGSGSSSVTPNSGGTPFSQDTAYSSCRLDTPNSYGQGTPLTPRLGTPFSQDSSYSSRQPTPSYLFSQDPAVTFKARRHESKFTDAYNRRHEHHYVHNSPAVTAVAGATAAFRGSSDLPFGAVGGTGGSSGPPFKAQPQDSATFAHTPPPAQATPAPGFKSAFSPYQTPVAHFPPPPEEPTATAAFGARDSGEFRRAPAPPPLPPAEPLAKEKPGTPPGPPPPDTNSMELGGRPTFGWSPEPCDSPGTPTLESSPAGPEKPHDSLDSRIEMLLKEQRTKLLFLREPDSDTELQMEGSPISSSSSQLSPLAPFGTNSQPGFRGPTPPSSRPSSTGLEDISPTPLPDSDEDEELDLGLGPRPPPEPGPPDPAGLLSQTAEVALDLVGDRTPTSEKMDEGQQSSGEDMEISDDEMPSAPITSADCPKPMVVTPGAAAVAAPSVLAPTLPLPPPPGFPPLPPPPPPPPPQPGFPMPPPLPPPPPPPPPAHPAVTVPPPPLPAPPGVPPPPILPPLPPFPPGLFPVMQVDMSHVLGGQWGGMPMSFQMQTQVLSRLMTGQGACPYPPFMAAAAAAASAGLQFVNLPPYRGPFSLSNSGPGRGQHWPPLPKFDPSVPPPGYMPRQEDPHKATVDGVLLVVLKELKAIMKRDLNRKMVEVVAFRAFDEWWDKKERMAKASLTPVKSGEHKDEDRPKPKDRIASCLLESWGKGEGLGYEGLGLGIGLRGAIRLPSFKVKRKEPPDTTSSGDQKRLRPSTSVDEEDEESERERDRDMADTPCELAKRDPKGVGVRRRPARPLELDSGGEEDEKESLSASSSSSASSSSGSSTTSPSSSASDKEEEQESTEEEEEAEEEEEEEVPRSQLSSSSTSSTSDKDDDDDDSDDRDESENDDEDTALSEASEKDEGDSDEEETVSIVTSKAEATSSSESSESSEFESSSESSPSSSEDEEEVVAREEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAPGAPAVDSLGMEEEVDIETEAVAPEERPSMLDEPPLPVGVEEPADSREPPEEPGLSQEGAMLLSPEPPAKEVEARPPLSPERAPEHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPSPPPEPETTDASHPSVPPEPLAEDHPPHTPGLCGSLAKSQSTETVPATPGGEPPLSGGSSGLSLSSPQVPGSPFSYPAPSPSLSSGGLPRTPGRDFSFTPTFSEPSGPLLLPVCPLPTGRRDERSGPLASPVLLETGLPLPLPLPLPLPLALPAVLRAQARAPTPLPPLLPAPLASCPPPMKRKPGRPRRSPPSMLSLDGPLVRPPAGAALGRELLLLPGQPQTPVFPSTHDPRTVTLDFRNAGIPAPPPPLPPQPPPPPPPPPVEPTKLPFKELDNQWPSEAIPPGPRGRDEVTEEYMELAKSRGPWRRPPKKRHEDLVPPAGSPELSPPQPLFRPRSEFEEMTILYDIWNGGIDEEDIRFLCVTYERLLQQDNGMDWLNDTLWVYHPSTSLSSAKKKKRDDGIREHVTGCARSEGFYTIDKKDKLRYLNSSRASTDEPPADTQGMSIPAQPHASTRAGSERRSEQRRLLSSFTGSCDSDLLKFNQLKFRKKKLKFCKSHIHDWGLFAMEPIAADEMVIEYVGQNIRQVIADMREKRYEDEGIGSSYMFRVDHDTIIDATKCGNFARFINHSCNPNCYAKVITVESQKKIVIYSKQHINVNEEITYDYKFPIEDVKIPCLCGSENCRGTLN

setd1b

Histone-lysine N-methyltransferase SETD1B

1956 amino acids

Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (By similarity).

Belongs to the class V-like SAM-binding methyltransferase superfamily.

218.069 kDa

MSFKEAKPGERGKNPEDHGRKQTASWINGMEAGNQPSTSGEKKSHHWRSYKLIIDPALRKGQHKLYRYDGLSFSMPNSGVPPVDSVRDPRIGRIWTKTKELDLPVPKLKIDEFYVGPVPPKQVTFAKLNDNIRENFLGDMCKKYGEVEEVEILYNPKNKKHLGIAKVIFASVKGARDAVKHLHNTSVMGNIIHVELDTKGETRMRFYDLLVNGFYTPQTLPVGSDLDASPTVNETPQVVESVKRTKETAIGPSVTPNSSTPFSHDTAYSSSRQGTPNSYSQFTPQSQGTPHTPRLGTPFSQDSSYSSRQTTPAFHYGQDSGFKPRRHENKFTDAYNRRPGHHYVHSSGSYRGTEHTFNVTRPQPEPVQVPRTPPLSHSSGNYKSAFSPYQGNTVFPQTDESQYPQTSRDMEYRRTGPQTSDSYSDAGCNSASLELKPVKEKPEEPPPPEPDSTTEQKASFSQTPERCETPGTPTLEAELQHNSLDTRIAMLLKEQRTQLHLIAGDQNSDNEIRMEGSPISSSSSQLSPIPPYSSGSRYQDVTPSSRPSSTGLEDISPTPLPDSDDDDEPIPGTASLCQNSRSASPIDQINQSGRKTESLDKKELVAGDETPTSEKMDEGHPSSGEDMEISDDEVTPSPITSAECAITSSSVISSVIPIPPPGFPPLPPPPPPQPGFPMPPPLPPPPPPTHPSVTVPPPPLPAPPGVPPHHILHHPPPYHHFPVMQGEMMNVLGNHWGGMTMSFQMQTQMLSRMMQGQGSYPYHHFMGGSMQFGNQHPYRPFAISAHLTRGQPWPPFPKFDPSVPPPGYEHKKEDPHKATVDGVLQVIVKELKAIMKRDLNRKMVEVVAFRAFDEWWDKKERLAKQSLTPVKSGESKEEDKQKTKEHITSSLLESWNKGEGLGFEGIGLGIGLRGAIRLPSFKVKRKEPPDAALAGDQKRIRPSHSVDDEDEESERDRDISSTASDLSKKDADAVNNRRRPARPLDSEGEEEVESEGDDGETSDKEDSSSEKEDQDDGSVSALSSKKQLYGDKEGDDEDDDTQSSGKEEDLVSEEEDTTSVASSRAEMDSSDESEESSEYESSSDSDEKEEEDDEEEELVFGDDQSEDQDLGQEYEVETDREEDFFRENLSECSSLPKAGDVELEDEMQKVEEDVARQTTQETLHLRKKNLDVPLVESKECKQDTLDKVEKLFAVPMQEEVFKEHEKAPSPMNEEEEYIELQLEPVPLVPEGAAPAAQEPVIIRPLTPTGAFGETGPVLKLEEPKLQVNLTQFATEDEELYPRTPGRDTAAHSDTEVTFQPGLKVAPSSLPFLPSHNKEEECLLPPEKHAGHLTVTKMLSEEDLPRTPGRDIVVKSSHLGKSQSTETVPATPGSDAPLTGSSLTLTSPHIPGSPFSYLSQSPGIINSGIPRTPGRDFNFTPTFPESNSIFPCHPSGKKPSVDEPDEKSFKEPTSASLTMNSVPSPIPFASPPRGLPHMDIRLGADDLESSDTPAYLSDKLLSEESECEFTKVHLTSTDESAPSPPLPPAEKRKGDRSKKPLSAHEFETEKNYETSSAVAMSEGALGKQMFIGQPDAVSGIKDPAAVPLDFRNDSLSENTVHEPIIQKVPLKELENQWNEVLKEEEDITKHKKSRNSRHNNRYDEFSTVPSPEFSPPRAMFKPRSEFEEMTILYDIWNGGIDDEDIKYMCITYDRLLQQDNGMDWLNDTLWVYHPSTSVYSPKKKKRDDGLREHVTGCARSEGYYKIDKKDKLKYLINNRSLTEELPIDTQGKSIPAQPQASTRAGSERRSEQRRLLSSFTGSCDSDLLKFNQLKFRKKKLRFCKSHIHDWGLFAMEPIIADEMVIEYVGQNIRQVIADMREKRYEDEGIGSSYMFRVDHDTIIDATKCGNFARFINHSCNPNCYAKVITVESQKKIVIYSKQYINVNEEITYDYKFPIEDVKIPCLCGAENCRGTLN

setd1b

Histone-lysine N-methyltransferase SETD1B

1938 amino acids

Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (By similarity).

Belongs to the class V-like SAM-binding methyltransferase superfamily.

216.257 kDa

MSFKEAKPGERGKNPEDHGRKQAASWMNGMEAANQPSTSAEKKSHHWRSYKLIIDPALRKGQQKLYRYDGLSFSMPNSGAPPVDSVRDPRIGRIWTKTKELDLPVPKLKIDEFYVGPVPPKQVTFAKLNDNIRENFLGDMCKKYGEVEEVEILYNPKNKKHLGIAKVIFATVKGAKDAVKHLHNTSVMGNIIHAELDTKGETRMRFYELLVNGYYTPQTLPVGSDLDASPTVNETPQVVEPVKRTKETAVGASVTPNSSTPFSHDTAYSSSRQGTPNSYSQFTPQSQGTPHTPRLGTPFSQDSSYSSRQTTPAFHYGQDSSFKPRRHENKFTDAYNRRPGHHYVHSSGSYRGPENTFNVTRPQAETVQFPRTPPLSHSSGNNKSAFSPYQGSTVFPQTDDNQYPQTSRDMEYRRTGPPTSDSYSDGSLELKLVKEKPEEPPPPEPDSTTEQKASFAQTPERCATPGTPTLEAEMQHDSLDTRIAMLLKEQRTQLHLISSDQNSDSEIRMEGSPISSSSSQLSPIPPYSSSSHYQDVTPSSRPSSTGLEDISPTPLPDSDDDEPIPGTASLCQNSRSASPIDQINQPVRKMETLDNKELVVGDETPTSEKMDEGHPSSGEDMEISDDEVTPSPITSAECAITSSSVIPILPPGFPPLPPPPPPQSGFPMPPPLPPPPPPTHPSVTVPPPPLPAPPGVPPHHILHHPPPYHHFPVMQGEMMNVLGNHWGGMTMSFQMQTQMLSRMMQGQGSYPYHHFMGGSMQFGNQLPYRPFALSAHLSRGQPWPPLPKFDPSVPPPGYEPKKEDPHKATVDGVLQVIVKELKAIMKRDLNRKMVEVVAFRAFDEWWDKKERLAKQSLTPVKSGESKDEDKQKTKEHITSSLLESWNKGEGLGFEGIGLGIGLRGAIRLPSFKVKRKEPPDAALAGDQKRIRPSHSVDDEDEESERDRDISGTASDLSKKDADAVNIRRRPARPLDSEGEEEVESEGDDGETSDKEAFEKEDQDAGSVSALSSKKRLYGEKEDEEDETQSSGKEEDLVSEEEDITSVASSRAEMDSSDESDESSEYESSSDSDDEIEEEDDDDEEEELVFEDDQSEELDLGQEDYIETDREEDFFKEDVSECSSPVKAEADMELEDDDVQKLEQDVAHQTAQDTSHLRKKDLDVPLVESKEHKQDTFDKMERLSAVPMQQNVFKEHEKAPSPMNEEEEYIELRLEPVPLVPDNAPPAVQEPMIIRPLTPTGAFGESGPVLKLEEPKLQVNLAHFVAEDEDLYPRTPGRDTAAHSDTEVTFQPGLKVAPSSLPLLQSHNKEEECLLPPEKHTGHLKVTKTLSEEELPRTPGRDILVKSSHLGKSQSTETIPATPGSDAPLTGNSLTLTSPHIPGSPFSYLSQSPGIINSGIPRTPGRDFNFTPIFPESNSIFPSHPSGKKSSVDEPDEKSFKEPTSASLTMNSVPSPIPFASPPRGVPHMDIRLETDDLESSDTQAYLSDKLLSEESECEFTKGQLPSTDESAPSPPFPPTDKRKGPKKPLAAHEFEACVALSEGALGKQLFIGQPDSVSGIKDPAAVPLDFRNDGLSENTVHDPIIQKVPLKELENQWNEVLKEEEEDISKHKKSRNSRLNKLYDEFSTLPSPEYSPPRAMFKPRSEFEEMTILYDIWNGGIDDEDMKYMCITYDRLLQQDNGMDWLNDTLWVYHPPTSVYSPKKKKRDDGLREHVTGCARSEGYYKIDKKDKLKYLINNRSLADEPPIDTQGKSIPAQPQASTRAGSERRSEQRRLLSSFTGSCDSDLLKFNQLKFRKKKIRFCKSHIHDWGLFAMEPIVADEMVIEYVGQNIRQVIADMREKRYEDEGIGSSYMFRVDHDTIIDATKCGNFARFINHSCNPNCYAKVVTVESQKKIVIYSKQYINVNEEITYDYKFPIEDVKIPCLCGAENCRGTLN