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SERPINA3-3

Gene
SERPINA3-3
Protein
Serpin A3-3
Organism
Bos taurus
Length
411 amino acids
Function
Serine protease inhibitor. Strongly inhibits elastase and trypsin stoichiometrically at the molar ratio of 1:1. Acts as a moderate inhibitor of plasmin and chymotrypsin. Does not inhibit thrombin, urokinase, kallikrein, tissue plasminogen activator, cathepsin G or the cysteine proteases papain, cathepsin B or cathepsin L.
Similarity
Belongs to the serpin family.
Mass
46.326 kDa
Sequence
MRAERLSPLLALGLLVAGIRSVHCLPENVVVKDRHRRVDGHTLASSNTDFAFSLYKQLALKNPNKNVMFSPLSVSMALAFLSLGARGPTLTEILEGLKFNLTEIQETQIHQGFQHLLQALNRPRNQLQLSVGNAMFVQEELKLLDKFIEDARVLYSSEAFPTNFRDPEAAKSLINDYVKNKTQGKIEELFKDLSPRTELVLVNYVYFKAQWKTRFDPKHTEQAEFHVSDNKTVEVPMMTLDLETPYFRDEELGCTLVELTYTSNDSALFILPDKGKMQDLEAKLTPEMLTRWRNSLQPRRIHELYLPKFSIKSNYELNDTLSQMGIKKIFTDADLSGITGTADLVVSQVVHGAALDVDEEGTEGAAATGIGIERTFLRIIVRVNRPFLIAVVLKDTQSIIFLGKVTNPSEA