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SELENOT

Gene
selenot
Protein
Thioredoxin reductase-like selenoprotein T
Organism
Xenopus tropicalis
Length
201 amino acids
Function
Selenoprotein with thioredoxin reductase-like oxidoreductase activity.
Similarity
Belongs to the SelWTH family. Selenoprotein T subfamily.
Mass
22.529 kDa
Sequence
MARSSGPLCLLLLGGLVAGILSGASADGNGLPSKKLKMQYTAGPLLKFQICVSUGYRRVFEDYMRVISQRYPDIRIEGENYLPHPIYRNIASFLSVFKLVLIGLIIAGKDPFAFFGMQAPSVWQWGQENKVYACMMVFFVSNMIENQCMSTGAFEITLNDVPVWSKLESGHLPSVQQLVQIIDNEMKLNVHMDAIPHHHRS

Gene
SELENOT
Protein
Thioredoxin reductase-like selenoprotein T
Organism
Gallus gallus
Length
199 amino acids
Function
Selenoprotein with thioredoxin reductase-like oxidoreductase activity.
Similarity
Belongs to the SelWTH family. Selenoprotein T subfamily.
Mass
22.318 kDa
Sequence
MRAAGLGLGIGLLLLAALAGPGGSAEQGGVPAKKLRMAYATGPLLKFQICVSUGYRRVFEEYMRVISQRYPDIRIEGENYLPQPIYRHIASFLSVFKLVLIGLIIVGKDPFAFFGMQAPSIWQWGQENKVYACMMVFFLSNMIENQCMSTGAFEITLNDVPVWSKLESGHLPSMQQLVQILDNEMKLNVHMESMPHHRS

Gene
SELENOT
Protein
Thioredoxin reductase-like selenoprotein T
Organism
Bos taurus
Length
195 amino acids
Function
Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity). Protects dopaminergic neurons against oxidative stress ans cell death (By similarity). Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (By similarity). Plays a role in fibroblast anchorage and redox regulation (By similarity). In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (By similarity). In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP-induced insulin secretion (By similarity).
Similarity
Belongs to the SelWTH family. Selenoprotein T subfamily.
Mass
22.248 kDa
Sequence
MRLLLLLLVAASAVVRSDASANLGGVPGKRLKMQYATGPLLKFQICVSUGYRRVFEEYMRVISQRYPDIRIEGENYLPQPIYRHIASFLSVFKLVLIGLIIVGKDPFAFFGMQAPSIWQWGQENKVYACMMVFFLSNMIENQCMSTGAFEITLNDVPVWSKLESGHLPSMQQLVQILDNEMKLNVHMDSIPHHRS

Gene
SELENOT
Protein
Thioredoxin reductase-like selenoprotein T
Organism
Homo sapiens
Length
195 amino acids
Function
Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity). Protects dopaminergic neurons against oxidative stress ans cell death (PubMed:26866473). Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (By similarity). Plays a role in fibroblast anchorage and redox regulation (By similarity). In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (By similarity). In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP-induced insulin secretion (By similarity).
Similarity
Belongs to the SelWTH family. Selenoprotein T subfamily.
Mass
22.324 kDa
Sequence
MRLLLLLLVAASAMVRSEASANLGGVPSKRLKMQYATGPLLKFQICVSUGYRRVFEEYMRVISQRYPDIRIEGENYLPQPIYRHIASFLSVFKLVLIGLIIVGKDPFAFFGMQAPSIWQWGQENKVYACMMVFFLSNMIENQCMSTGAFEITLNDVPVWSKLESGHLPSMQQLVQILDNEMKLNVHMDSIPHHRS

Gene
Selenot
Protein
Thioredoxin reductase-like selenoprotein T
Organism
Mus musculus
Length
195 amino acids
Function
Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity). Protects dopaminergic neurons against oxidative stress ans cell death (PubMed:26866473). Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (By similarity). Plays a role in fibroblast anchorage and redox regulation (PubMed:19935881). In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (By similarity). In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP-induced insulin secretion (PubMed:23913443).
Similarity
Belongs to the SelWTH family. Selenoprotein T subfamily.
Mass
22.292 kDa
Sequence
MRLLLLLLVAASAVVRSEASANLGGVPSKRLKMQYATGPLLKFQICVSUGYRRVFEEYMRVISQRYPDIRIEGENYLPQPIYRHIASFLSVFKLVLIGLIIVGKDPFAFFGMQAPSIWQWGQENKVYACMMVFFLSNMIENQCMSTGAFEITLNDVPVWSKLESGHLPSMQQLVQILDNEMKLNVHMDSIPHHRS

Gene
Selenot
Protein
Thioredoxin reductase-like selenoprotein T
Organism
Rattus norvegicus
Length
195 amino acids
Function
Selenoprotein with thioredoxin reductase-like oxidoreductase activity (PubMed:26866473). Protects dopaminergic neurons against oxidative stress ans cell death (By similarity). Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (PubMed:18198219). Plays a role in fibroblast anchorage and redox regulation (By similarity). In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (PubMed:26779623). In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP-induced insulin secretion (By similarity).
Similarity
Belongs to the SelWTH family. Selenoprotein T subfamily.
Mass
22.292 kDa
Sequence
MRLLLLLLVAASAVVRSEASANLGGVPSKRLKMQYATGPLLKFQICVSUGYRRVFEEYMRVISQRYPDIRIEGENYLPQPIYRHIASFLSVFKLVLIGLIIVGKDPFAFFGMQAPSIWQWGQENKVYACMMVFFLSNMIENQCMSTGAFEITLNDVPVWSKLESGHLPSMQQLVQILDNEMKLNVHMDSIPHHRS