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SDHAF1

Gene
SDHAF1
Protein
Succinate dehydrogenase assembly factor 1, mitochondrial
Organism
Bos taurus
Length
118 amino acids
Function
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF3. Contributes to iron-sulfur cluster incorporation into SDHB by binding to SDHB and recruiting the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20.
Similarity
Belongs to the complex I LYR family. SDHAF1 subfamily.
Mass
13.253 kDa
Sequence
MSRHSRLQRQVLSLYRELLRAGRGKPGAEARVRAEFRQHACLPRSDVLRIEYLYRRGRRQLQMLRSGHATAMGAFVRTRGPTEESNGAGAPGTLSGEGDDPRKPLDSMRTPKTPLDGR

Gene
Sdhaf1
Protein
Succinate dehydrogenase assembly factor 1, mitochondrial
Organism
Mus musculus
Length
118 amino acids
Function
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit Sdhb of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF3. Contributes to iron-sulfur cluster incorporation into SDHB by binding to SDHB and recruiting the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20.
Similarity
Belongs to the complex I LYR family. SDHAF1 subfamily.
Mass
13.142 kDa
Sequence
MSRPSRLQRQVLSLYRELLRAGRGTPGAEARVRAEFRQHASLPRTDVLRIEYLYRRGRRQLQLLRSGHATAMGTFVRPRGPAEEPGDATAPGTRLDDGGAPKNSCEDTGARETRSDGR

Gene
Sdhaf1
Protein
Succinate dehydrogenase assembly factor 1, mitochondrial
Organism
Rattus norvegicus
Length
118 amino acids
Function
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit Sdhb of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF3. Contributes to iron-sulfur cluster incorporation into SDHB by binding to SDHB and recruiting the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20.
Similarity
Belongs to the complex I LYR family. SDHAF1 subfamily.
Mass
13.312 kDa
Sequence
MSRLSRLQRQVLSLYRELLRAGRGKPGAEARVRAEFRQHASLPRSDVLRIEYLYRRGRRQLQLLRSGHATAMGTFVRPRGPTEEPVDATAPGNRLDDSDALKNPCEGTGARETRSDGR

Gene
SDHAF1
Protein
Succinate dehydrogenase assembly factor 1, mitochondrial
Organism
Homo sapiens
Length
115 amino acids
Function
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol (PubMed:24954417, PubMed:19465911). Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants (PubMed:24954417). May act together with SDHAF3 (PubMed:24954417). Contributes to iron-sulfur cluster incorporation into SDHB by binding to SDHB and recruiting the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20 (PubMed:26749241).
Similarity
Belongs to the complex I LYR family. SDHAF1 subfamily.
Mass
12.806 kDa
Sequence
MSRHSRLQRQVLSLYRDLLRAGRGKPGAEARVRAEFRQHAGLPRSDVLRIEYLYRRGRRQLQLLRSGHATAMGAFVRPRAPTGEPGGVGCQPDDGDSPRNPHDSTGAPETRPDGR