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SCP1

Gene
scp1
Protein
Sterol regulatory element-binding protein cleavage-activating protein
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
1086 amino acids
Function
Escort protein required for sre1 processing at low sterol as well as oxygen levels. May regulate export of the scp1/sre1 complex from the ER at low sterol or oxygen levels. 4-methyl sterols bound to scp1 may mask an ER-export signal in scp1 leading to retention of the complex in the ER. Release of 4-methyl sterols may trigger a conformational change in the SSC domain of scp1 unmasking the ER export signal leading to recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of sre1 in the Golgi, release of the transcription factor fragment of sre1 from the membrane, its import into the nucleus and up-regulation of genes required for ergosterol biosynthesis as well as anaerobic growth.
Similarity
Belongs to the WD repeat SCAP family.
Mass
125.129 kDa
Sequence
MRIFTLGKGRISRGYARQVNPSLFAKYSYCIANNPWYFILVFTLLSITGIYSSLVAYQQSLYDQSLARWSAWYAESINAEANVITKQLYLLGTNTSVFSEDYLSNAYRWETSFHQYLAEYGYPCIRDEKSCVTISPIPKYYGKVDPVAQYSYTKGLPENEREVNKLRNDTIAEGFDSLSAFVITYFLKPEQVDTFHVVLKKFISETPNLYASLLDTSPTTVVARIPDLTVIYRWYLWVGFGVGLFAYLYLSLVRLHDIRAKFGLTATIFIQSGTAYFSTCSLLYFFERTGPICPWPMAYYIIIFMDIENSFRLLRAVIASPQTKRVPSRIMEGFSSTIIASFSSLLKKLLTLFVLSFFVYPLVQEFCLFLACSFVVSFLLHGSFFLAVLSVDIRRLELQDFLDSNSSNRNSKWWVPYLEYVRFMWSPWIIDNLGTVSFHMYVIYLQLQSSTDINGSWRLASPNIRFLITLYHRLGRILRERKLFPLITTGWFGDPTFLEALKEKTMAENLVIALYRPVILDTVNRRDYTNVYNSFHDRRVWRWSTFFSILFAIDFAVGLLVKALLRGWSDHDELSTDTTLHEEKFRIEPVPVHHQLDILKIAVSENYKTFASVGLDRCLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGNYVSLFSKDTLFILNVESPCLMLQHSYHCKPNSKLNVFWMPGTHKDDEWKNFELVVVESSGEIQVFSLTIEIEGADIALVEKFQLSSPIIKSISIVSPTANRIACLTESGEVTVYSKKGPVWSPKILSQNKNYLTETKKDIYGIAMADILFLARDSGVDMIDLKNDELLHSFTLPPIKVNTFSVGVSNSRFVNGQFRVSSISFCFTHAVTEKVLYYYYGNECNESYIILNKWDQQPNLVDVHDPDNSLACLTFDELQENIHEVEDASECVMSSDGLYIFGMRRKSSSGICPTADEKNEDNGFTLRNRKLRTGHYNWTSYVPLLDSYMQDMEHKKNTHSGGETQVWEVWMYSQSEKKHRCKSLKMYNSLIIADPGPSLAVSDRCVAIVLGNYVALVGYGSEIFRDFYQIRNSDEMDRILRRKRKNLQRKRSGTIGC

Gene
SCP1
Protein
Synaptonemal complex protein 1
Organism
Mesocricetus auratus
Length
845 amino acids
Function
Major component of the transverse filaments of synaptonemal complexes, formed between homologous chromosomes during meiotic prophase (By similarity). Has non-specific DNA binding capability.
Mass
99.401 kDa
Fragment
single
Sequence
IVELQFEKEKVSLKLEEEIQENKDLIKENNATRHLCNLLKETSARSAEKTNKYEYEREETRQVYVDLNNNIEKMILAFEELRVQAENARLDMHFKLKEDHEKIQHLQEEYKKEVNDKENQVSLLLIQRTEKENKMKDLTFLLEESRDKVNQLEDKTKLQDENVKELNKKKDHLTSELEDTKMSLQRSMNTQKALEEDLQIATKTIYQLTEEKEAQMEEFNKAKTDHSFMVTELKATTCTLEELLRTEQQRLVKNEDQLKILTMELQKKSNELDEMTKFKNNNEVKLEELKKILAEDQKLLDEKKQVEKLAEELQGKEQELTLLLQTREKEVHDLEEQLLVTKISDQNYSKQVEELKTKLEEEKLKNAELTASCGKLSLENNKLTQETNDMALELKKYQEDITNSKKQEERMLKQIENLEEKETHLRDELESVRKEFIQQGNEVKCKLDKSEENARSIECEVLKKEKQMKILENKCNNLRKQAENKSKYIEELHQENKALKKKSSAESKQLNAYEIKVNKLQLELESAKQKFQEMTDNYQKEIEVKKISEEKLLGEVEKAKAMVDEAVKLQKEIDLRCQHKIAEMVALMEKHKHQYDKIVEERDSELGLCKNREQEQLSVKTALETELSNIRNELVSLKKQLEIEREEKEKLKLEKENTAILKDKKDKKIQTSLLESAETTCQKFDSKTTPSQNISRISSSMESGKTKDNRDCLRTSAKILSTAFVKEYTVKTPTKMQMYQRENKYIPTGRSNKKRKTVFEFDVNSDSSETTDLLSMVSEEEISNRLYNNNSPNSHLTPKQTPLSLSTPESFVSLGGVRKMREDRWATIAKTDRKRRLKEAEKLFA

Gene
SCP1
Protein
Transgelin
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
200 amino acids
Function
Has actin-binding and actin-bundling activity. Stabilizes actin filaments against disassembly.
Mass
22.748 kDa
Sequence
MSYDKKADVTSLDEDLRQLRESKFSPEAIQNIKIWVYKSVLKEIAPPGDLLECLKDGTVLCKLANILYEADTGEANHISWKSSKMPFVQMDQISQFLSFSRKYGVPEDELFQTIDLFEKKDPAIVFQTLKSLSRYANKKHTDRFPVLGPQLSTKKPRPPVKSKPKHLQDGTGWSTFEYGYMKGASQATEGVVLGQRRDIV