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SBH1

Gene
SBH1
Protein
Sphinganine C4-monooxygenase 1
Organism
Arabidopsis thaliana
Length
260 amino acids
Function
Involved in sphingolipid trihydroxy long-chain base (4-hydroxysphinganine) biosynthesis. Can use C18- and C20-sphinganine as substrates to produce C18- and C20-phytosphinganines (D-ribo-2-amino-1,3,4-trihydroxyoctadecane and -eicosane).
Similarity
Belongs to the sterol desaturase family.
Mass
29.819 kDa
Sequence
MMMGFAVSDELLGTVAPIVVYWLYSGIYVALSSLESYRLHSKVEEEEKNLVSKSSVVKGVLVQQVVQAVVAILLFTVTGSDAEADKAQQFSFLVLARQFVTAMIVLDTWQYFMHRYMHQNKFLYKHIHSQHHRLIVPYAYGALYNHPVEGLLLDTIGGALSFLVSGMSPRTSIFFFSFATIKTVDDHCGLWLPGNLFHMVFKNNSAYHDIHHQLYGTKYNFSQPFFVMWDRILGTYMPYSLEKREDGGFEARPTKEFKDD

Gene
sbh1
Protein
Protein transport protein sec61 subunit beta
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
102 amino acids
Function
Necessary for protein translocation in the endoplasmic reticulum.
Similarity
Belongs to the SEC61-beta family.
Mass
10.444 kDa
Sequence
MSSTKASGSVKNSAASAPGGPKSQIRRRAAVEKNTKESNSGPAGARAAGAPGSTPTLLKLYTDEASGFKVDPVVVMVLSVGFIASVFLLHIVARILKKFASE

Gene
SBH1
Protein
Protein transport protein Sec61 subunit beta
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
91 amino acids
Function
Necessary for protein translocation in the endoplasmic reticulum.
Similarity
Belongs to the SEC61-beta family.
Mass
9.545 kDa
Sequence
MSTSAQVPGGPAAQMKRRNNAQRQEAKASQRPTSTRSVGAGGSSSTMLKLYTDESQGLKVDPVVVMVLSLGFIFSVVALHILAKVSTKLLG

Gene
SBH1
Protein
Protein transport protein Sec61 subunit beta
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
88 amino acids
Function
Necessary for protein translocation in the endoplasmic reticulum.
Similarity
Belongs to the SEC61-beta family.
Mass
9.428 kDa
Sequence
MDSSVPGGQRTLQKRRNAQLQKEKKANQTPASPRQAGFGGSSSSILKLYTDEANGLRVDPLVVLFLAVAFVFSVVALHVVAKVSGKIF

Gene
SBH1
Protein
Protein transport protein SBH1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
82 amino acids
Function
Part of the Sec61 complex, which is the major component of a channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). The functional states of the translocon complex include co- and post-translational ER import, cotranslational membrane protein integration and retrograde transport of misfolded proteins out of the ER. In the cotranslational pathway, ribosomes synthesizing presecretory proteins are targeted to the translocon by the cytosolic signal recognition particle (SRP) and its ER-localized receptor. The association of the Sec61 complex with the ribosome is mediated by the 28S rRNA of the large ribosomal subunit. SRP-independent post-translational translocation requires the association of additional factors, such as the Sec62/63 complex and KAR2.
Similarity
Belongs to the SEC61-beta family.
Mass
8.711 kDa
Sequence
MSSPTPPGGQRTLQKRKQGSSQKVAASAPKKNTNSNNSILKIYSDEATGLRVDPLVVLFLAVGFIFSVVALHVISKVAGKLF