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SBF2

Gene
sbf2
Protein
Myotubularin-related protein 13
Organism
Xenopus laevis
Length
1873 amino acids
Function
Guanine nucleotide exchange factor (GEF) which may activate Rab small GTPases (By similarity). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity). Acts as an adapter for the phosphatase mtmr2 (By similarity).
Similarity
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
Mass
210.866 kDa
Sequence
MARLADYFIVVGYDHEKTGSEGFGKIIQRFPMTDWSDTPFPQGIELFCQPGGWQLSRERKQPTFFIVVLTDIDSDRHYCACLTFYEAEINLQGTKREHSETEEEDSGLIQPAQVFAPKSLVLVSRLDYPEIFRACLGLIYTVYIDSLNVSLENLVSNLVTCIVPCAGGSQKLFSLGAGDRQLIQTPLHDSLPVTGTSVALLFQQLGIQNVLSLFCAVLTENKVLFHSSSFQRLGDACRALEALIYPLKYSYPYIPILPAQLLEVLSSPTPFIIGVHSVFCSEIHDLLDVIIADLDGGTIKIPECIHLSPIPEPLLHQTQAALSLVLHPDLEVADNAFAPLRTPVPHIKLLDKEVRAVFLRLFAQIFQGYRSCLQLIRIHAEPIIHFHKAAFLGQRGLIENDFLTKVLSGMSFAGFVSERGPPYRPCDLFDELVSFEVERIKDDDQNDTHKILKHIRELAEQLFKNENPNPHMAFQKVPKPTEGSHLRVHILPFSKMNDLKVQELIQEGLNKNQNSILSPRAEKKCVVPAGSPVVSIVDKASSVFNSARRLEVVRNCIMYIFENKTLETEKTLPAALRALKGKAARQCLTEELALHVQQNRSMLNHQQFDYIVRMMNCALQDCSGSEEYTIASQLLPLATAFCRKLSAAVSQFAYTCVQDHGVWANQQFWETTFYNDVQNQVRSLYLTTKNGNQGASEPKENGVDSGNPERTVMDLAAEQLRLWPTLSKETQQELIQSEESTVFSQAIHFANLMVYLLVPLDTSKNKLLRTSATGDWESGSNSIVTNSIAGSVAESYDTESGFEDSENDIANSVVRFITRFIDKVCTESGVTQDHIKSLHCMIPGIVAMHIETLEAVHRESRRLPPIKKPKIMRPALLPGEEFVCEALRVLLDPDGREEATGGMLGGPHILPAEGALFLTTYRIIFKGTPHDALVGEQTVIRSVPIASITREKKINVQNQLHQNMQEGLQIRSATFQLIKVAFDEEVSAEMVDLFKKQLMKFRYPLSIFSAFAFAAGQTAPPIILPKQKEKNTSFRTISKTIVKGAKRAGKMTIGRQYAAKKKTGTILEERGSRSGGNEDDDISVSDDNELPSGTLKPSEKSTMEQLVERACFRDYQRLALGTISNSSTRFKSEHFRVTALNRMHSLCRSYPGLLVVPQSVQDSSLQKVARCYRHNRLPVVSWKNAKTNAVLLRGGGFHGKTVVGLFKSQNTHTAAPASSLESSSSIEQEKYLQALLNAISVHYKMNGNSTLTVRPTLALSPGSDRKSSRMSSVVKHVVPSHVDGSLSHSFARGGVWASLRSSNRLITTQTPLIDVGARLVGKDLQTTYTDHSALQSQLLKRQAALYIFGEKSQLRGFKFDFALNCEFVPVEFGDIRQVKTSFKKLMRACVPSSNPTDSESTFLKAMGESEWFLQIHRIIQLSVIISELMESGSSVMICLEDGWDITTQVVSLVQILGDPFYRTLEGFRMLIEKEWLSFGHKFSQRSNLSPSSQGTGFVPIFLQFLDCVHQIHNQYPTEFEFNRYYLKFLAYHHVSNRFKTFLLDSDYERLEHGTLFEDKGDKHSRRGICIWEYIERIHKKKTVFFNYLFAPTELEALKPSANISTLRKWEYYMEETLASGPSYDWIITPSRFNASDETDSGEEAQQQGKRKIVWPCYDDVQKVQPDAITHLMNEIERLEIKLNQTSERWQLLWERAKVKLKENAKKENNNPASLVSANLQSYQKRSMVHLPDSGLGDEQNLNASPSNGVDRRTATLYNHFTSKNEENRSYEGILYKRGALLKGWKPRWFVLDITKHQLRYYDSGEDTSCKGYIDLADVETVVPAAPTIGAPKHANEKAFFDVKTSKRVYNFCAQDAQSAQLWMDKIQNCISDA

Gene
Sbf2
Protein
Myotubularin-related protein 13
Organism
Mus musculus
Length
1872 amino acids
Function
Guanine nucleotide exchange factor (GEF) which activates RAB21 and possibly RAB28 (By similarity). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity). In response to starvation-induced autophagy, activates RAB21 which in turn binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (By similarity). Acts as an adapter for the phosphatase MTMR2 (PubMed:16399794). Increases MTMR2 catalytic activity towards phosphatidylinositol 3,5-bisphosphate and to a lesser extent towards phosphatidylinositol 3-phosphate (PubMed:16399794).
Similarity
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
Mass
210.458 kDa
Sequence
MARLADYFIVVGYDHEKPAGPGEGLGKIIQRFPQQDWDDTPFPQGIELFCQPGGWHLSRERKQPTFFVVVLTDIDSDRHYCSCLTFYEAEINLQGTKKEEIEGEEVSGLIQPAEVFAPKSLVLVSRLDYPEIFRACLGLIYTVYVDSMSVSLESLIANLCACLVPAAGGSQKLFSLGAGDRQLIQTPLHDSLPVTGTSVALLFQQLGIQNVLNLFCAVLTENKVLFHSASFQRLSDACRALESLMFPLKYSYPYIPILPAQLLEVLSSPTPFIIGVHSIFKTDVHELLDVIIADLDGGTIKIPECIHLSSLPEPLLHQTQSALSLILHPDLEVADHAFPPPRTALSHSKMLDKEVRAVFLRLFAQLFQGYRSCLQLIRIHAEPVIHFHKTAFLGQRGLVENDFLTKVLNGMAFAGFVSERGPPYRACDLFDELVAFEVERIKVEEKNPLKMIKHIRELAEQLFKNENPNPHMAFQKVPRPTEGSHLRVHILPFPKINEARVQELIQENLAKNQNAPPATRIEKKCVVPAGPPVVSIMEKVITVFNSAQRLEVVRNCISFIFENKTLETEKTLPAALRALKGKAARQCLTDELGLHVQQNRAILDHQQFDYIIRMMNCTLQDCSSLEEYNIAAALLPLTSAFYRKLAPGVSQFAYTCVQDHPIWTNQQFWETTFYNAVQEQVRSLYLSAKDDNHIPHLKQKLPDGQHQEKTAMDLAAEQLRLWPTLSKSTQQELVQHEESTVFSQAIHFANLMVNLLVPLDTSKNKLLRASAPGDWESGSNSIVTNSIAGSVAESYDTESGFEDSENSDVANSVVRFIARFIDKVCTESGVTQDHIRSLHCMIPGIVAMHIETLEAVHRESRRLPPIQKPKILRPALLPGEEIVCEGLRVLLDPDGREEATGGLLGGPQLLPAEGALFLTTYRILFRGTPHDQLVGEQTVVRSFPIASITKEKKITMQNQLQQSVQEGLQITSASFQLIKVAFDEEVSPEVVDIFKKQLMKFRYPQSIFSTFAFAAGQTTPQIILPKQKEKNTSFRTFSKTIVKGAKKAGKMTIGRQYLLKKRTGTIVEERVNRPGWNEEDDISVSDDSELPTSTTLKASEKSTMEQLVEKACFRDYQRLGLGTISGNSSRSKPEYFRVTASNRLYSLCRSYPGLLVIPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLLRSGGFHGKGVVGLFKSQNSPQAVSTSSLESSSSIEQEKYLQALLTAVIVHQKLRGSSTLTVRPALALSPVHGYRDKSFTQSNPKSSAKEPVHNQGVWASLRSSTRLISSPTSFIDVGARLAGKDHSASFSNSTYLQNQLLKRQAALYIFGEKSQLRSSKVEFAFNCEFVPVEFHEIRQVKASFKKLMRACIPSTIPTDSEVTFLKALGDSEWFPQLHRIMQLAVVVSEVLENGSSVWVCLEEGWDITTQVTSLAQLLSDPFYRTIAGFRTLVEKEWLSFGHKFSQRSSLALNSQGGGFAPIFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYERLEHGTLFDDKGDKHAKKGVCIWECIDKMHTRSPIFFNYLYSPVEVEALKPNVNVSSLKKWDYYTEETLSAGPSYDWMMLTPKHFPYEESDVAGGAGPQSQRKTVWPCYDDVTCSQPDALTRLFSEIEKLEHKLNQTPERWHQLWEKVTTDLKEEPRTAHSLRHSAGSPGIASTNVPSYQKRPALHPLHRGLGEDQSTTTAPSNGVEHRAATLYSQYTSKNDENRSFEGTLYKRGALLKGWKPRWFVLDVTKHQLRYYDSGEDTSCKGHIDLAEVEMVIPAGPSMGAPKYTSDKAFFDLKTSKRVYNFCAQDGQSAQQWMDRIQSCISDA

Gene
SBF2
Protein
Myotubularin-related protein 13
Organism
Homo sapiens
Length
1849 amino acids
Function
Guanine nucleotide exchange factor (GEF) which activates RAB21 and possibly RAB28 (PubMed:20937701, PubMed:25648148). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:20937701, PubMed:25648148). In response to starvation-induced autophagy, activates RAB21 which in turn binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed:25648148). Acts as an adapter for the phosphatase MTMR2 (By similarity). Increases MTMR2 catalytic activity towards phosphatidylinositol 3,5-bisphosphate and to a lesser extent towards phosphatidylinositol 3-phosphate (By similarity).
Similarity
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
Mass
208.464 kDa
Sequence
MARLADYFIVVGYDHEKPGSGEGLGKIIQRFPQKDWDDTPFPQGIELFCQPGGWQLSRERKQPTFFVVVLTDIDSDRHYCSCLTFYEAEINLQGTKKEEIEGEAKVSGLIQPAEVFAPKSLVLVSRLYYPEIFRACLGLIYTVYVDSLNVSLESLIANLCACLVPAAGGSQKLFSLGAGDRQLIQTPLHDSLPITGTSVALLFQQLGIQNVLSLFCAVLTENKVLFHSASFQRLSDACRALESLMFPLKYSYPYIPILPAQLLEVLSSPTPFIIGVHSVFKTDVHELLDVIIADLDGGTIKIPECIHLSSLPEPLLHQTQSALSLILHPDLEVADHAFPPPRTALSHSKMLDKEVRAVFLRLFAQLFQGYRSCLQLIRIHAEPVIHFHKTAFLGQRGLVENDFLTKVLSGMAFAGFVSERGPPYRSCDLFDELVAFEVERIKVEENNPVKMIKHVRELAEQLFKNENPNPHMAFQKVPRPTEGSHLRVHILPFPEINEARVQELIQENVAKNQNAPPATRIEKKCVVPAGPPVVSIMDKVTTVFNSAQRLEVVRNCISFIFENKILETEKTLPAALRALKGKAARQCLTDELGLHVQQNRAILDHQQFDYIIRMMNCTLQDCSSLEEYNIAAALLPLTSAFYRKLAPGVSQFAYTCVQDHPIWTNQQFWETTFYNAVQEQVRSLYLSAKEDNHAPHLKQKDKLPDDHYQEKTAMDLAAEQLRLWPTLSKSTQQELVQHEESTVFSQAIHFANLMVNLLVPLDTSKNKLLRTSAPGDWESGSNSIVTNSIAGSVAESYDTESGFEDSENTDIANSVVRFITRFIDKVCTESGVTQDHIKSLHCMIPGIVAMHIETLEAVHRESRRLPPIQKPKILRPALLPGEEIVCEGLRVLLDPDGREEATGGLLGGPQLLPAEGALFLTTYRILFRGTPHDQLVGEQTVVRSFPIASITKEKKITMQNQLQQNMQEGLQITSASFQLIKVAFDEEVSPEVVEIFKKQLMKFRYPQSIFSTFAFAAGQTTPQIILPKQKEKNTSFRTFSKTIVKGAKRAGKMTIGRQYLLKKKTGTIVEERVNRPGWNEDDDVSVSDESELPTSTTLKASEKSTMEQLVEKACFRDYQRLGLGTISGSSSRSRPEYFRITASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLLRSGGFHGKGVVGLFKSQNSPQAAPTSSLESSSSIEQEKYLQALLNAVSVHQKLRGNSTLTVRPAFALSPGVWASLRSSTRLISSPTSFIDVGARLAGKDHSASFSNSSYLQNQLLKRQAALYIFGEKSQLRNFKVEFALNCEFVPVEFHEIRQVKASFKKLMRACIPSTIPTDSEVTFLKALGDSEWFPQLHRIMQLAVVVSEVLENGSSVLVCLEEGWDITAQVTSLVQLLSDPFYRTLEGFQMLVEKEWLSFGHKFSQRSSLTLNCQGSGFAPVFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYERLEHGTLFDDKGEKHAKKGVCIWECIDRMHKRSPIFFNYLYSPLEIEALKPNVNVSSLKKWDYYIEETLSTGPSYDWMMLTPKHFPSEDSDLAGEAGPRSQRRTVWPCYDDVSCTQPDALTSLFSEIEKLEHKLNQAPEKWQQLWERVTVDLKEEPRTDRSQRHLSRSPGIVSTNLPSYQKRSLLHLPDSSMGEEQNSSISPSNGVERRAATLYSQYTSKNDENRSFEGTLYKRGALLKGWKPRWFVLDVTKHQLRYYDSGEDTSCKGHIDLAEVEMVIPAGPSMGAPKHTSDKAFFDLKTSKRVYNFCAQDGQSAQQWMDKIQSCISDA