Protein
Lipoate--protein ligase 2
Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Function
Catalyzes specifically the lipoylation of GcvH-L (SAV0324), likely via the ATP-dependent activation of lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domain of the target protein. Can also utilize lipoamide as substrate for GcvH-L modification.
Similarity
Belongs to the LplA family.
Sequence
MYLIEPIRNGEYITDGAIALAMQVYVNQHIFLDEDILFPYYCDPKVEIGRFQNTAIEVNQDYIDKHSIQVVRRDTGGGAVYVDKGAVNMCCILEQDTSIYGDFQRFYQPAIKALHTLGATDVIQSGRNDLTLNGKKVSGAAMTLMNNRIYGGYSLLLDVNYEAMDKVLKPNRKKIASKGIKSVRARVGHLREALDEKYRDITIEEFKNLMVTQILGIDDIKEAKRYELTDADWEAIDELADKKYKNWDWNYGKSPKYEYNRSERLSSGTVDITISVEQNRIADCRIYGDFFGQGDIKDVEEALQGTKMTREDLMHQLKQLDIVYYFGNVTVESLVEMILS