SAC3

Nuclear mRNA export protein SAC3

1301 amino acids

Component of the SAC3-THP1 complex, which functions in transcription-coupled mRNA export from the nucleus to the cytoplasm. SAC3-THP1 functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket), by association with components of the nuclear mRNA export machinery (MEX67-MTR2 and SUB2) in the nucleoplasm and the nucleoporin NUP1 at the nuclear basket.

Belongs to the SAC3 family.

149.569 kDa

MNTSFGSVVPSTNFNFFKGHGNNDNTSANSTVNNSNFFLNSNETKPSKNVFMVHSTSQKKSQQPLQNLSHSPSYTENKPDKKKKYMINDAKTIQLVGPLISSPDNLGFQKRSHKARELPRFLINQEPQLEKRAFVQDPWDKANQEKMISLEESIDDLNELYETLKKMRNTERSIMEEKGLVDKADSAKDLYDAIVFQGTCLDMCPTFERSRRNVEYTVYSYEKNQPNDKKASRTKALKVFARPAAAAAPPLPSDVRPPHILVKTLDYIVDNLLTTLPESEGFLWDRMRSIRQDFTYQNYSGPEAVDCNERIVRIHLLILHIMVKSNVEFSLQQELEQLHKSLITLSEIYDDVRSSGGTCPNEAEFRAYALLSKIRDPQYDENIQRLPKHIFQDKLVQMALCFRRVISNSAYTERGFVKTENCLNFYARFFQLMQSPSLPLLMGFFLQMHLTDIRFYALRALSHTLNKKHKPIPFIYLENMLLFNNRQEIIEFCNYYSIEIINGDAADLKTLQHYSHKLSETQPLKKTYLTCLERRLQKTTYKGLINGGEDNLASSVYVKDPKKDRIPSIADQSFLMENFQNNYNEKLNQNSSVKPQINTSPKRVATRPNHFPFSQESKQLPQISQSHTLSTNPLLTPQVHGDLSEQKQQQIKTVTDGGSPFVFDQSAQNSTVEASKAHMISTTSNGAYDEKLSSEQEEMRKKEEQRIEEEKTQLKKKQENADKQVITEQIANDLVKEVVNSSVISIVKREFSEANYRKDFIDTMTRELYDAFLHERLYLIYMDSRAELKRNSTLKKKFFEKWQASYSQAKKNRILEEKKREEIKLVSHQLGVPGFKKSTCLFRTPYKGNVNSSFMLSSSDKNLIFSPVNDEFNKFATHLTKISKLWRPLEMQSIYYDNLTKKFPSNSLTPANLFIYAKDWTSLSNRWILSKFNLQTAQDSKKFSNNIISSRIICIDDEYEPSDFSDLQLLIFNTGVTNPDIFDLEMKLKDDGEELIKLITGISLNTNICFSLLIIYWESAENTLSESTIKHLLKLNRISKNYSSVIERIDLMNLTEESPHKCLEDKLSEISHSYVYKLTERGKYDKTLRQKRSLAGIHSRSTQLQTTKDIDQKMKKMLEKEKNKYQQQIGERNTYAHLESHIDASPRSKKRKLPILLSTSHSSQFKTPLASRLNTSGSSTSPPLPSHLAMKFRKNSRVTSLHTVLPVSTPSHSNNIPAASFSGNNTTDIQSQQLIENQKSTSVYLNNVSERILGNQEICQTPINPVTPVLDGADQGKEDIPDSILELKILIDSVKKKVNND

SAC3

Phosphoinositide phosphatase SAC3

818 amino acids

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).

92.747 kDa

MSSSTDDAGTTTHSLQEFKLFETQSNFYMIGWDGSGVYRVLKIDRLDPSELNISQDSTHYTKKECYELLKRIHEGNKATGGLKLVTLCYGIIGFVKFLGPYYMLLITERRHIGDLFGHSVYAVSKSEIVALHNSTVQCNFANSRDENRYKRLLCMVDLTKDFFFSYSYNVMRSYQKNVCNYETGHNLYEKMFVWNEFLTRGIRHHLRNTLWTVALVYGFFKQASLSESGKDFKITLIARRSRHNAGTRYLKRGVNRNGDVANDVETEQIVSEDVPEDHPMQISSVVQNRGSIPLFWSQETSRLNLKPDIVLSKKEPNYEATRLHFDNLVERYGNPIIILNLIKTKERRPRESILREEFVNAIDFINKDLPEENRLRFLHWDLHKHFRSKTKNVLALLCKVATCALMLTDLFYYQVTPAMTIEDSMSLSSSSDADTGDISPHTSSDDDNGDHDSLEKKSSRSKNIAYGKCDVKPPRLQSGVLRTNCIDCLDRTNVAQYAYGWAALGQQLHVLGIRDVPAIELDDPLAISLMGLYERMGDTLAHQYGGSAAHNKVFSERRGQWRAATQSQEFLRTLQRYYNNAYMDADKQDAINIFLGTFQPEQGMPAIWELRSNSLSNGRNGEMNIGKDERFLVKRCLSDGDFLHESCTPLSAMSSNHESMPQKGFSAPLQHVSHILSESSSDIPVSNDVALSRCTPSMPRKQLFGDVQKVHRFGSDQVYFGGEEDMSSVSNFVDIEWLSSENPCENALFDRSSELTRNLTAETSSTENSVNGVGQSAPTISESGSSSSKGKEPMGTKIREDFPDSFKEWVAYGEALCH

SAC3

Actin-3

376 amino acids

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension growth.

Belongs to the actin family.

41.609 kDa

MADAEDIEPLVCDNGTGMVKAGFAGDDAPRAVFPSIVGRPRHTGVMVGMGQKDXYVGDEAQSKRGILTLKYPIEHGIVSNWDDMEKIWHHTFYNELRVVSEEPXVLSXEAPLNPKVNRESAQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGDALPHAILRLDLAGRDLTDHLMKILTERGYMFTTSAEREIVRDMKEKLAYVALDYEQELETAKSSSSVEKSHELPDGQVITIGAERFRCPKILFQPSMIEMEAAGIHETTYNSIMKCDVDIRKDLYGNIVLSGGSTMFLGIADRMSKEITALAPSSMKIKVVAPPERKYSVWIGGSILASLSTFQQMWISKGEYDESGPSIVHRKCF