Protein
HTH-type transcriptional repressor Rv1474c
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function
Represses the expression of the aconitase gene acn and its own expression, in an iron-responsive manner. Binds to the inverted repeat element present in the upstream region of acn (Rv1475c)-Rv1474c operon. Preferentially binds to major groove of the DNA.
Sequence
MPKVSEDHLAARRRQILDGARRCFAEYGYDKATVRRLEQAIGMSRGAIFHHFRDKDALFFALAREDTERMAAVASREGLIGVMRDMLAAPDQFDWLATRLEIARKLRNDPDFSRGWAERSAELAAATTDRLRRQKQANRVRDDVPSDVLRCYLDLVLDGLLARLASGEDPQRLAAVLDLVENSVRRS