Rv0191

Gene

Rv0191

Protein

Chloramphenicol efflux pump Rv0191

Organism

Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Length

413 amino acids

Function

Active efflux pump that plays an important role in chloramphenicol resistance (PubMed:31054279). Overexpression causes pyrazinamide resistance (PubMed:28584158).

Similarity

Belongs to the major facilitator superfamily.

Mass

42.911 kDa

Sequence

MTAPTGTSATTTRPWTPRIATQLSVLACAAFIYVTAEILPVGALSAIARNLRVSVVLVGTLLSWYALVAAVTTVPLVRWTAHWPRRRALVVSLVCLTVSQLVSALAPNFAVLAAGRVLCAVTHGLLWAVIAPIATRLVPPSHAGRATTSIYIGTSLALVVGSPLTAAMSLMWGWRLAAVCVTGAAAAVALAARLALPEMVLRADQLEHVGRRARHHRNPRLVKVSVLTMIAVTGHFVSYTYIVVIIRDVVGVRGPNLAWLLAAYGVAGLVSVPLVARPLDRWPKGAVIVGMTGLTAAFTLLTALAFGERHTAATALLGTGAIVLWGALATAVSPMLQSAAMRSGGDDPDGASGLYVTAFQIGIMAGALLGGLLYERSLAMMLTASAGLMGVALFGMTVSQHLFENPTLSPGDG

Protein

Chloramphenicol efflux pump Rv0191: Rv0191