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Reut_A1963

Gene
Reut_A1963
Protein
Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase
Organism
Cupriavidus necator (strain JMP 134 / LMG 1197)
Length
165 amino acids
Function
Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity).
Similarity
Belongs to the class II aldolase/RraA-like family.
Mass
17.319 kDa
Sequence
MKHVTTDLCDANEPRLADGTLRVMAPVFRAFGKQQAFAGPAATLKIFEDNSLVREALESPGQGRVLVVDGGGSLRCALVGGNLGLLAEKNGWVGIIVNGCVRDTGELDVCDIGIRALAAHPQKSQKRGAGERDVAVQMPGAVVRPGNWIYVDADGVLVSEEKLGA