Rep

Gene

rep

Protein

ATP-dependent DNA helicase Rep

Organism

Escherichia coli (strain K12)

Length

673 amino acids

Function

Similarity

Belongs to the helicase family. UvrD subfamily.

Mass

77.024 kDa

Sequence

MRLNPGQQQAVEFVTGPCLVLAGAGSGKTRVITNKIAHLIRGCGYQARHIAAVTFTNKAAREMKERVGQTLGRKEARGLMISTFHTLGLDIIKREYAALGMKANFSLFDDTDQLALLKELTEGLIEDDKVLLQQLISTISNWKNDLKTPSQAAASAIGERDRIFAHCYGLYDAHLKACNVLDFDDLILLPTLLLQRNEEVRKRWQNKIRYLLVDEYQDTNTSQYELVKLLVGSRARFTVVGDDDQSIYSWRGARPQNLVLLSQDFPALKVIKLEQNYRSSGRILKAANILIANNPHVFEKRLFSELGYGAELKVLSANNEEHEAERVTGELIAHHFVNKTQYKDYAILYRGNHQSRVFEKFLMQNRIPYKISGGTSFFSRPEIKDLLAYLRVLTNPDDDSAFLRIVNTPKREIGPATLKKLGEWAMTRNKSMFTASFDMGLSQTLSGRGYEALTRFTHWLAEIQRLAEREPIAAVRDLIHGMDYESWLYETSPSPKAAEMRMKNVNQLFSWMTEMLEGSELDEPMTLTQVVTRFTLRDMMERGESEEELDQVQLMTLHASKGLEFPYVYMVGMEEGFLPHQSSIDEDNIDEERRLAYVGITRAQKELTFTLCKERRQYGELVRPEPSRFLLELPQDDLIWEQERKVVSAEERMQKGQSHLANLKAMMAAKRGK

Protein

Gene

rep

Protein

ATP-dependent DNA helicase Rep

Organism

Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)

Length

670 amino acids

Function

Similarity

Belongs to the helicase family. UvrD subfamily.

Mass

78.501 kDa

Sequence

MLFNEHQKKAISYISGPCLILAGAGSGKTRVIINKIVHLIKICHFDPKCITAITFTNKAACEMKSRILNVLSVNVSNLVKISTFHALGLEIIKSEIELLNIKSNFTIFDEQDQISILQEIVSKEDRSFVRQIRQSISNWKNKLLCPNQVNKISNSSIEFKFFRYYELYNAYLKSSNILDFDDLIFLPTILLRDNKLSRERWNDKIKYLLVDEYQDTNFIQYKLIKLLSSKRSNFTLVGDDDQSIYSWRGANIHNFESLKHDYPNLRTIIMQHNYRSSGRILKVANALISNNLHFFNKKLFSNLDYGSIVEIISAKNEEDEARVILQTLMLHKSNYNAQYKDYAILYRSNYQVKIFEKFLIKFKIPYKILANISFFSRPEIKDLIAYLRLIINPDDNAAFLRVVNRPLRGIGAVTLQKLKEWSKKRNQSFFMASLDIGLESILPVHNLKSLQEFVYLIQTISYQIQLNPIEVLEKLVATIKYEKWLMRSLKFSKLYVASIKNISIVLNWIINELKYKIMNSKKFVMKYLIDIISEFILQNSLNEDIVINNDYVQLMTLHASKGLEFLYVFIVGVEEGVLPYYRNTTMENNIDEERRLAYVGITRAQKKLFLSYAIQRCQYGVVINTKPSRFLRELPQSDILWQKSKILNLNEKNNFLFKAYKKSLKKKLLR

Protein

Gene

rep

Protein

ATP-dependent DNA helicase Rep

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Length

670 amino acids

Function

Similarity

Belongs to the helicase family. UvrD subfamily.

Mass

77.746 kDa

Sequence

MKLNPQQQQAVEYVTGPCLVLAGAGSGKTRVIINKIAHLIEKCGYSPKQIAAVTFTNKAAREMKERVAHSIGKEQSKGLLVSTFHTLGFDILKREYKALGFKSNMTLFDEHDQFALLKELTADVLKEDKDLLRELISVISNWKNDLISPKQAFALARDAKYQTFAKCYERYATQIRTYNALDFDDLIMLPTLLFKQNEEVRSKWQAKIRYLLVDEYQDTNTSQYELIKLLVGDRACFTVVGDDDQSIYSWRGARPENMVRLRDDFPRLNVIKLEQNYRSTQRILHCANILIDNNEHVFDKKLFSTIGKGEKLLVIEAKNEEHEAERIVAELIAHRFSRKTKYKDYAILYRGNHQSRLLEKVLMQNRIPYKISGGTSFFSRAEIKDMMAYLRLVVNQDDDAAFLRIVNTPKREIGTATLQKLGELAQEKHISLFEAIFEFELIQRITPKAYDSLQKFGRWIVELNDEIQRSEPERAVRSMLSAIHYEEYLYEYATSPKAAEMQSKNVATLFDWVADMLKGDETNEPMNLNQVVTRLTLRDMLERGEDDDDSDQVQLMTLHASKGLEFPYVYLIGMEEGILPHQTSIDEDNVEEERRLAYVGITRAQKELTFSLCRERRQYGELVRPEPSRFLAELPNDDVLWERDKPKLTTEQKQEKTQNQLDRLRAILKS

Protein

Gene

rep

Protein

ATP-dependent DNA helicase Rep

Organism

Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)

Length

658 amino acids

Function

Similarity

Belongs to the helicase family. UvrD subfamily.

Mass

77.509 kDa

Sequence

MSLNFNQKNAIELINGPCLILAGAGSGKTKVIINKIIYLINNCQYKPGNIIAVTFTNKAAHEIKVRLAKHLNLLQIKKMIISTFHSLGLEIIKKEINTLKFNSNFSLFDERDQMMLLKKICSKSIKNDTKLLKKLVFMISFWKNKFLTPLQVQLSAQSNLEKDFAFFYKQYTFHLRKSNILDFDDLICIPTSLLKNNQIIQNRWQKKISYLLVDEYQDTNNSQYELIKMLTNVNSNFTLVGDDDQSIYSWRGAKPQNLFLIKKDFPNLKIIKMEQNYRSYGRILKAANKLISNNLHYFKKKLFSNLEYGNKIKVIIGKNEKNEAEKIADKIIHECSNDIMQYKDYAILYRGNYQSQILEKTFLKKNIPYDISTNSSFFSRPEIKDLLSYLRLIVNPDDNHAFIRILNIPHRQIGLTTLNKLEELASKKNKSLFQISNDIEIKKILRERTVKKIKDFIYWIKKIIKLSLLKEDIILDKIINDIKYELWLTKILKEPKKIKTSINNIYTLSNWLKEMLRGNEFEKPMNLLQIVKKMTLRDILEKKIQINEIPKNRVQLMTLHSSKGLEFSSVFIIGMNEGILPNIKSINNDNIEEERRLTYVGMTRARKELFFTYCQTRIQYGQKLYTAPSRFLFELPQEDLQWEKDDYLDAFHTKEKKI

Protein

Gene

rep

Protein

ATP-dependent DNA helicase Rep

Organism

Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)

Length

645 amino acids

Function

Similarity

Belongs to the helicase family. UvrD subfamily.

Mass

75.814 kDa

Sequence

MSLNFSQKNAVELTNGPCLILAGAGSGKTKVIINKIIYLINHCQYEPDNIAAVTFTNKAAYEMRIRLSKYLNIPEIKKIIISTFHSLGLEIIKKEIDALELNNNFTLLDEKDQILLLKKICKKEIKNNIQLLKKLNFMISYWKNKFLTPLQVQLLAKSSQEKDFAYVYEQYTNYLYKANILDFDDLICMPTLLLKNNKKIKIRWQKKISYLLVDEYQDTNNSQYELIKMLANKNSDFTLVGDDDQSIYSWRGANPQNIFLLKKDFPNLKIIKMEHNYRSSGRILKAANSLIANNIHYLEKKLFSQLKYGNLIKVLIGKNEENEAQKIVKKIISQYAKKKIKYRDFAILYRGNYQSRILEKALIKENIPYNISEKSSFFSRPEIKDLLSYLRVVINRDDNHAFMRIVNIPSRQIGKTTLKKLEEWANKKHVSLFQASNNIEIKKFLNENTIKKIKNFISKIEKFTAWSCLKPSNIIDDIVDDLEYEKWLSKFLKDPNKIKNSINNVHTLSQWFKNMIKGDDFEKPMTLFQIVTRMTIRDILDDNIIKEQQDRVQLMTLHASKGLEFPAVFIIGMCEGILPNQKSIDNDNIEEERRLTYVGITRAKKQLFFTYCYKRTQYGQILDMLPSRFLFELPQEDLKWEKKIF

Protein

Rab escort protein 1: REP

Gene

REP

Protein

Rab escort protein 1

Organism

Arabidopsis thaliana

Length

563 amino acids

Function

Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component composed of the alpha subunit RGTA and the beta subunit RGTB (Probable). Preferentially binds the GDP-bound form of Rab and stimulates geranylgeranylation of various Rab GTPases in vitro (PubMed:15854662).

Similarity

Belongs to the Rab GDI family.

Mass

61.511 kDa

Sequence

MIDIPPYPPLDPSNYDLIVVGTGVSESVLAAAASSSGSSVLHLDPNPFYGSHFASLSLPDLTSFLHSNSVSPPPSPSSPPLPPSNNHDFISVDLVNRSLYSSVEISSFESEILEEHSRRFNVDLAGPRVVFCADESINLMLKSGANNYVEFKSIDASFVGDSSGELRNVPDSRAAIFKDKSLTLLEKNQLMKFFKLVQSHLASSTEKDDSTTVKISEEDMESPFVDFLSKMRLPPKIKSIILYAIAMLDYDQDNTETCRHLLKTKEGIDRLALYITSMGRFSNALGALIYPIYGQGELPQAFCRRAAVKGCIYVLRMPITALLLDKETGGYKGVRLASGQEIFSQKLILDPCVTVGLESLSSLTDQQNETLSVLVPKSMINKEKIARGVCVIRGSVKANVSNALVVYPPKSLFPEQLTAIRVLQLGSGLAVCPADMHVLYLSTLCDNDDQGIKALLSAMSNLISLPVPENRQSDSVVENDTSETKPILLWRALYVQELVKGEFGGTISSMPSPDGNLNYNEIVESAVKLYEKLMGSEELFKEETSPAENTTEEENDGGVEIED

Protein

Gene

rep

Protein

Replicase polyprotein 1ab

Organism

Porcine transmissible gastroenteritis coronavirus (strain FS772/70)

Length

533 amino acids

Function

NendoU is a Mn(2+)-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond.

Mass

60.27 kDa

Fragment

single

Sequence

LDSEVVTCFDNSIAGSFERFTTTRDAVLISNNAVKGLSAIKLQYGLLNDLPVSTVGNKPVTWYIYVRKNGEYVEQIDSYYTQGRTFETFKPRSTMEEDFLSMDTTLFIQKYGLEDYGFEHVVFGDVSKTTIGGMHLLISQVRLAKMGLFSVQEFMNNSDSTLKSCCITYADDPSSKNVCTYMDILLDDFVTIIKSLDLNVVSKVVDVIVDCKAWKWMLWCENSHIKTFYPQLQSAEWNPGYSMPTLYKIQRMCLERCNLYNYGAQVKLPDGITTNVVKYTQLCQYLNTTTLCVPHKMRVLHLGAAGASGVAPGSTVLRRWLPDDAILVDNDLRDYVSDADFSVTGDCTSLYIEDKFDLLVSDLYDGSTKSIDGENTSKDGFFTYINGFIKEKLSLGGSVAIKITEFSWNKDLYELIQRFEYWTVFCTSVNTSSSEGFLIGINYLGPYCDKAIVDGNIMHANYIFWRNSTIMALSHNSVLDTPKFKCRCNNALIVNLKEKELNEMVIGLLRKGKLLIRNNGKLLNFGNHFVNTP

Protein

Gene

rep

Protein

Replicase polyprotein 1ab

Organism

Avian infectious bronchitis virus (strain KB8523)

Length

521 amino acids

Function

NendoU is a Mn(2+)-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond.

Mass

58.2 kDa

Fragment

single

Sequence

GGGGQSFLAADNAVLVSTQCYKRHSYVEIPSNLLVQNGMSLKDGANLYVYKRVNGAFVTLPNTLNTQGRSYETFEPRSDVERDFLDMSEEDFVEKYGKDLGLQHILYGEVDKPQLGGLHTVIGMYRLLRANKLNAKSVTNSDSDVMQNYFVLADNGSYKQVCTVVDLLLDDFLELLRNILNEYGTNKSKVVTVSIDYHSINFMTWFEDGSIKTCYPQLQSAWTCGYNMPELYKVQNCVMEPCNIPNYGVGITLPSGIMMNVAKYTQLCQYLSKTTVCVPHNMRVMHFGAGSDKGVAPGSTVLKQWLPEGTLLVDTDIVDYVSDAHVSVLSDCNKYKTEHKFDLVISDMYTDNDSKRKHGGVIANNGNDDVFIYLSSFLRNNLALGGSFAVKLTETSWHESLYDIAQDCAWWTMFCTAVNASSSEAFLIGVNYLGASVKVKVSGKTLHANYIFWRNCNYLQTSAYSIFDVAKFDLRLKATPVVNLKTEQKTDLVFNLIKCGKLLVRDVGNTSFTSDSFVCTM

Protein

Rab proteins geranylgeranyltransferase component A: Rep

Gene

Rep

Protein

Rab proteins geranylgeranyltransferase component A

Organism

Drosophila melanogaster

Length

511 amino acids

Function

Binds unprenylated Rab proteins, presents it to the catalytic component B, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab to a protein acceptor (By similarity).

Similarity

Belongs to the Rab GDI family.

Mass

56.827 kDa

Sequence

MLDDLPEQFDLVVIGTGFTESCIAAAGSRIGKSVLHLDSNEYYGDVWSSFSMDALCARLDQEVEPHSALRNARYTWHSMEKESETDAQSWNRDSVLAKSRRFSLDLCPRILYAAGELVQLLIKSNICRYAEFRAVDHVCMRHNGEIVSVPCSRSDVFNTKTLTIVEKRLLMKFLTACNDYGEDKCNEDSLEFRGRTFLEYLQAQRVTEKISSCVMQAIAMCGPSTSFEEGMQRTQRFLGSLGRYGNTPFLFPMYGCGELPQCFCRLCAVYGGIYCLKRAVDDIALDSNSNEFLLSSAGKTLRAKNVVSAPGYTPVSKGIELKPHISRGLFISSSPLGNEELNKGGGGVNLLRLLDNEGGREAFLIQLSHYTGACPEGLYIFHLTTPALSEDPASDLAIFTSQLFDQSDAQIIFSSYFTIAAQSSKSPAAEHIYYTDPPTYELDYDAAIANARDIFGKMFPDADFLPRAPDPEEIVVDGEDPSALNEHTLPEDLRAQLHDMQQATQEMDIQE

Protein

Gene

rep

Protein

Replicase polyprotein 1ab

Organism

Murine coronavirus (strain defective JHM)

Length

500 amino acids

Function

Non-structural protein 1: binds to the 40S ribosomal subunit and inhibits host translation. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response (By similarity).

Similarity

Belongs to the coronaviruses polyprotein 1ab family.

Mass

55.246 kDa

Fragment

single

Sequence

Protein

Gene

rep

Protein

Protein rep

Organism

Streptomyces lividans

Length

456 amino acids

Function

Essential for the autonomous replication of the plasmid pIJ101.

Similarity

Belongs to the Gram-positive plasmids replication protein type 1 family.

Mass

49.617 kDa

Sequence

MDPASGVIVAQTAAGTSVVLGLMRCGRIWLCPVCAATIRHKRAEEITAAVVEWIKRGGTAYLVTFTARHGHTDRLADLMDALQGTRKTPDSPRRPGAYQRLITGGTWAGRRAKDGHRAADREGIRDRIGYVGMIRATEVTVGQINGWHPHIHAIVLVGGRTEGERSAKQIVATFEPTGAALDEWQGHWRSVWTAALRKVNPAFTPDDRHGVDFKRLETERDANDLAEYIAKTQDGKAPALELARADLKTATGGNVAPFELLGRIGDLTGGMTEDDAAGVGSLEWNLSRWHEYERATRGRRAIEWTRYLRQMLGLDGGDTEADDLDLLLAADADGGELRAGVAVTEDGWHAVTRRALDLEATRAAEGKDGNEDPAAVGERVREVLALADAADTVVVLTAGEVAEAYADMLAALAQRREEATARRRREQDDDQDDDADDRQERAARHIARLASGPTSH

Protein

Geminivirus-like replication protein: rep

Gene

rep

Protein

Geminivirus-like replication protein

Organism

Onion yellows phytoplasma (strain OY-M)

Length

434 amino acids

Function

Introduces an endonucleolytic nick, thereby initiating the rolling circle replication (RCR).

Similarity

Belongs to the geminiviridae Rep protein family.

Mass

51.992 kDa

Sequence

MKKTNNIKKETMFQAQNIFLTYSQCDLSKEEIKTFIINLCNEKKLQINYLIIGIENHQDHKGKHHHVFFQLNKQFRTRDLTIFNIPKNIKEKKLIDHENIKIKDFFYSPHIEPRPGNPIKDTTDVRNYVKKDGDFIEEGTFKHVRYIKLSKNEKPTELESLTNNYFLKLRKEYQQKEINISKTKNEIFKKLKLYAESLEPNYAFKNAKRFKNMVFEYIFESDIKELPIFDFCTFKKIPILISIYDILETQKEQLSNSISKRFKTLIVEGNSKSGKTQFFKSVLTNLELPFNYIKDDVDFSDENYDEDKCVNIYDDIDIYDIQARNLTKVVIGNQKDSIVNMKYKPRTKIKGTDISIMLVNEDTSIEKYCFDNFKRGRKEYKYIRENAIFINLDKHTITHYEYQKYENEQAVIQHFEMPKNWDGLLYFLDQENES

Protein

Gene

rep

Protein

Replication protein

Organism

Clostridium perfringens

Length

406 amino acids

Function

Is involved in replication of pIP404.

Mass

48.801 kDa

Sequence

MRNALKLNKKNYIDNIHSRSKGWITRSVIDKKGYSQWHYKYAELKDLDMSDENIYITLNTFYKPCRRLENIKELNTLFIDLDYYKTGKTKDQVLMDLEKNYFNQSIPIPNYVIDSGRGMYLIWIINAVPSKALPLWKAVQEYLYNQLKYFGADRQALDATRILRVPGSINSKSKTVVNILDEYEYIYDLREIQNGFLPELKPYERKKGRPSKINYIYRERSLYYGRIQDIIKLCELREYDLKGHRELILFLYRYYLCSFTEDIEKALNDVLELNSMFRQHLSEREVIRATRSAERCYLDKNKQYKYKNETLIELLEITEEEQKYMTIIISKKEYKRRENIRGKKNYQEQLKAKGKATKKEELNVLRKKIKALKEKGFKNKEITLMLEVPIKTLERHITYMKKNGLL

Protein

Replication protein: rep

Gene

rep

Protein

Replication protein

Organism

Onion yellows phytoplasma (strain OY-M)

Length

377 amino acids

Function

Is essential for plasmid replication. Nicks the positive strand at the plus origin of replication (By similarity).

Similarity

Belongs to the Gram-positive plasmids replication protein type 2 family.

Mass

44.377 kDa

Sequence

MKLRICELVINKTLITKTKIETILETKKKAIQNYAYILHDKDIYQNEKEAQLNGKKVGDIKAPHWHIYLRFNYSQDTKHISQWFNTQENFVSKIKGRFSDALMYMIHANRLDKHQYDEKEVVSNFDWKSEAQQDIFNRKYKMDARLKDILLKIHSGEIKEYNINDNINILENNIYATAIEKAFKFRIRDLKKKVRQMECIFITGLSGSGKSTLAKKIAEDKNYEAYISSGSNDILDDYCGEECIILDDLRSNCLGLSDLLKMLDNNTASSVKSRYKNKVLECQLIIITTVKSIDDFFEDIFRKDESIIQLKRRCKLHIKIDSKYIYYSVWNPIEMKYDLIEKKPNNLLNDFQIKSLSKKEAKDYIKSISNIDLDKDC

Protein

Replication protein: rep

Gene

rep

Protein

Protein rep

Organism

Bacillus amyloliquefaciens

Length

339 amino acids

Similarity

Belongs to the Gram-positive plasmids replication protein type 1 family.

Mass

39.642 kDa

Sequence

MYSSENDYSILEDKTATGKKRDWRGKKRRANLMAEHYEALEKRIGAPYYGKKAERLSECAEHLSFKRDPETGRLKLYQAHFCKVRLCPMCAWRRSLKIAYHNKLIIEEANRQYGCGWIFLTLTVRNVKGERLKPQISEMMEGFRKLFQYKKVKTSVLGFFRALEITKNHEEDTYHPHFHVLLPVKRNYFGKNYIKQAEWTSLWKRAMKLDYTPIVDIRRVKGRVKIDAEQIESDVREAMMEQKAVLEISKYPVKDTDVVRGSKVTDDNLNTVFYLDDALSARRLIGYGGILKEIHKELNLGDAEGGDLVKIEEEDDEVANGAFEVMAYWHPGIKNYILK

Protein

Gene

rep

Protein

Protein rep

Organism

Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)

Length

320 amino acids

Function

Produces a single-strand nick in a specific site of the plasmid, and this nick results in single-strand replication by rolling circle mechanism.

Similarity

Belongs to the Gram-positive plasmids replication protein type 1 family.

Mass

37.533 kDa

Sequence

MEKWENQDKILLDKNKRGKDRNWRGRKLLSLKLADIFKELGYRETLIERVETCGDTLRFIRREDGSLRLYQAYFCKNKLCPMCNWRRSMKYSYQTSQIVDEAIKEQPKGRFLFLTLTVKNVPGKELNATISQLTQSFDRLFRRAKVKKNLIGFLRSVEVTHNQEEETYHPHIHVLMMVKSSYFSGAGDNYVSQEEWGRMWEQSLKVDYVPMVDIRSVKEIGKGLKGAILETAKYPIKPIKLDVENKQVVGDLYNGLYRKRQLGYGGLFKEIRKRLQLSNVENGDLVYTSDDNDEMSKGTKIVAIWNATKQNYFVKNKGWN

Protein

Replication-associated protein: rep

Gene

rep

Protein

Replication-associated protein

Organism

Pigeon circovirus

Length

317 amino acids

Function

Essential for the replication of viral ssDNA. The closed circular ssDNA genome is first converted to a superhelical dsDNA. Rep and/or Rep' binds a specific hairpin at the genome origin of replication. Introduces an endonucleolytic nick within the conserved sequence 5'-AGTATTAC-3' in the intergenic region of the genome, thereby initiating the rolling circle replication (RCR). Following cleavage, binds covalently to the 5'-phosphate of DNA as a tyrosyl ester. The cleavage gives rise to a free 3'-OH that serves as a primer for the cellular DNA polymerase. The polymerase synthesizes the (+) strand DNA by rolling circle mechanism. After one round of replication, a Rep-catalyzed nucleotidyl transfer reaction releases a circular single-stranded virus genome, thereby terminating the replication. Displays origin-specific DNA cleavage, nucleotidyl transferase, ATPase and helicase activities. ATPase activity is probably carried by the isoform Rep (By similarity).

Similarity

Belongs to the nanoviruses/circoviruses replication-associated protein family.

Mass

36.254 kDa

Sequence

MAPCKPGSNPPKGRVSAAEGGARREATRRPPREAAAKRWCFTLNNPTEEEIKSLETWLVSDFHYAIVGKEVGEQGTPHLQGFVHLKQKKRLPQLKQLFKRAHWEKARGSDEDNEKYCSKEGNVLLTLGIPAKGNRSDLSEAVAAVKAGRAMTEVARDFSEIYVKYGRGLRDLKLLIGQQPRDFKTEVIVITGPPGCGKSRWAADYPGSKFYKMKGEWWDGYDHQEVVIIDDFYGWLPFCELLRVTDRYPHKVPVKGAFVEFTSRVIIVTSNSPPDAWYSEERCCVQALFRRINKWLVWNHDKFEDAPDCMKKYPINY

Protein

Gene

rep

Protein

Protein rep

Organism

Lactobacillus plantarum

Length

317 amino acids

Function

Produces a single-strand nick in a specific site of the plasmid, and this nick results in single-strand replication by rolling circle mechanism.

Similarity

Belongs to the Gram-positive plasmids replication protein type 1 family.

Mass

37.009 kDa

Sequence

MSEIFEDKTENGKVRPWRERKIENVRYAEYLAILEFKRAHDVRGCGEVLRFRKIGEHLKLYQTWFCHKRLCPLCNWRRSMKNSSQLKQIIAEAVAREPKGRFLFLTLTVKNAHSAEELKVSLRALTKAFNKLTRYKKVTKNLLGYLRSTEITVNEQDGSYNQHLHVLLFVKSSYFKNSNNYLAQAEWAKLWQKALKVDYEPVVHVQAVKANKRKGTDSLQASAEETAKYEVKSADYMTADDERNLVVIKNLEYALAGTRQISYGGLLKQIKQDLKLEDVENGDLVHVGDEDYTKEQMEAAEEVVAKWDFNKQNYFIW

Protein

Gene

Rep

Protein

Replication-associated protein

Organism

Porcine circovirus 2

Length

314 amino acids

Function

Similarity

Belongs to the nanoviruses/circoviruses replication-associated protein family.

Mass

35.762 kDa

Sequence

MPSKKNGRSGPQPHKRWVFTLNNPSEDERKKIREPPISLFDYFIVGEEGNEEGRTPHLQGFANFVKKQTFNKVKWYLGARCHIEKAKGTDQQNKEYCSKEGNLLIECGAPRSQGQRSDLSTAVSTLLESGSLVTVAEQHPVTFVRNFRGLAELLKVSGKMQKRDWKTNVHVIVGPPGCGKSKWAANFADPETTYWKPPRNKWWDGYHGEEVVVIDDFYGWLPWDDLLRLCDRYPLTVETKGGTVPFLARSILITSNQTPLEWYSSTAVPAVEALYRRITSLVFWKNATEQSTEEGGQFVTLSPPCPEFPYEINY

Protein

Replication initiation protein: rep

Gene

rep

Protein

Replication initiation protein

Organism

Staphylococcus aureus

Length

314 amino acids

Function

This protein is probably a specific topoisomerase involved in initiating replication. This protein is specifically required and may be rate-limiting for replication of the plasmid in vivo.

Similarity

Belongs to the plasmid replication initiation factor family.

Mass

37.874 kDa

Sequence

MYKNNHANHSNHLENHDLDNFSKTGYSNSRLSGNFFTTPQPELSFDAMTIVGNLNKTNAKKLSDFMSTEPQIRLWDILQTKFKAKALQEKVYIEYDKVKADSWDRRNMRVEFNPNKLTHEEMLWLKQNIIDYMEDDGFTRLDLAFDFEDDLSDYYAMTDKAVKKTIFYGRNGKPETKYFGVRDSDRFIRIYNKKQERKDNADVEVMSEHLWRVEIELKRDMVDYWNDCFDDLHILKPDWTTPEKVKEQAMVYLLLNEEGTWGKLERHAKYKYKQLIKEISPIDLTELMKSTLKENEKQLQKQIDFWQREFRFWK

Protein

Gene

rep

Protein

Protein rep

Organism

Lactobacillus hilgardii

Length

314 amino acids

Function

Produces a single-strand nick in a specific site of the plasmid, and this nick results in single-strand replication by rolling circle mechanism.

Similarity

Belongs to the Gram-positive plasmids replication protein type 1 family.

Mass

37.045 kDa

Sequence

MSKKILKDVSRNRKERPWRERKLENLQYAEYLRILNFKKANRVKECGEVLRFVADDEGRLRLYQTWFCKSRLCPLCNWRRSMGQSNQLMQVLDEAHKQRKTGRFLFLTLTAENASGENLKQEVRKMGRAISKLFQYKKPAKNLLGYVRSTEITINKNGTYHQHMHVLLFVKPTYFKDSANYINQAEWSKLWQRAMKLDYQPIVNVEAVRSNKAKGKNSLIASAQETAKYQVKSKDILTNDQERDLQVVEDLEQGLAGSRQISYGGLFKEIRKQLQLEDVDAHLINVDDDKVKIDEVVREVVAKWDYNKQNYFIW

Protein

Gene

Rep

Protein

Replication-associated protein

Organism

Porcine circovirus 1 (isolate China)

Length

312 amino acids

Function

Similarity

Belongs to the nanoviruses/circoviruses replication-associated protein family.

Mass

35.635 kDa

Sequence

MPSKKSGPQPHKRWVFTLNNPSEEEKNKIRELPISLFDYFVCGEEGLEEGRTPHLQGFANFAKKQTFNKVKWYFGARCHIEKAKGTDQQNKEYCSKEGHILIECGAPRNQGKRSDLSTAVSTLLETGSLVTVAEQFPVTYVRNFRGLAELLKVSGKMQQRDWKTAVHVIVGPPGCGKSQWARNFAEPSDTYWKPSRNKWWDGYHGEEVVVLDDFYGWLPWDDLLRLCDRYPLTVETKGGTVPFLARSILITSNQAPQEWYSSTAVPAVEALYRRITTLQFWKTAGEQSTEVPEGRFEAVDPPCALFPYKINY

Protein

Gene

rep

Protein

Replicase polyprotein 1ab

Organism

Rat coronavirus (strain 681)

Length

307 amino acids

Function

Similarity

Belongs to the coronaviruses polyprotein 1ab family.

Mass

34.721 kDa

Fragment

single

Sequence

FNKFGKARLYYEALSFEEQDEIYAYTKRNVLPTLTQMNLKYAISAKNRARTVAGVSILSTMTGRMFHQKCLKSIAATRGVPVVIGTTKFYGGWDDMLRRLIKDVDSPVLMGWDYPKCDRAMPNILRIVSSLVLARKHDSCCSHTDRFYRLANECAQVLSEIVMCGGCYYVKPGGTSSGDATTAFANSVFNICQAVSANVCSLMACNGHKIEDLSIRELQKRLYSNVYRADHVDPAFVSEYYEFLNKHFSMMILSDDGVVCYNSEFASKGYIANISAFQQVLYYQNNVFMSEAKCWVETDIEKGPHEF

Protein

Gene

rep

Protein

Replicase polyprotein 1ab

Organism

Turkey coronavirus (strain Minnesota)

Length

306 amino acids

Function

The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products.

Similarity

Belongs to the coronaviruses polyprotein 1ab family.

Mass

34.874 kDa

Fragment

single

Sequence

FNKFGKARLYYEMSLEEQDQLFESTKKNVLPTITQMNLKYAISAKNRARTVAGVSILSTMTNRQFHQKILKSIVNTRNAPVVIGTTKFYGGWDNMLRNLIQGVEDPILMGWDYPKCDRAMPNLLRITASLVLARKHTNCCTWSERIYRLYNECAQVLSETVLATGGIYVKPGGTSSGDATTAYANSVFNIIQATSANVARLLSVITRDIVYDDIKSLQYELYQQVYRRVNFDPAFVEKFYSYLCKNFSLMIFADDGVVCYNNTLAKQGLVADISGFREILYYQNNVYMADSKCWVEPDLEKGPHEF

Protein

Probable replication protein rep: rep

Gene

rep

Protein

Probable replication protein rep

Organism

Bifidobacterium longum (strain NCC 2705)

Length

297 amino acids

Similarity

Belongs to the initiator RepB protein family.

Mass

34.068 kDa

Sequence

MSNEIVKFSNQFNNVALKKFDAVHLDVLMAIASRVRERGTATVEFSFEELRGLMRLKQNLTNKQLADKIVQTNARLLALNYMFEDSGKIIQFALFTVFETDPANQTLEVSVNERFAFLLNDLTSQFTRFELAEFADLKSKYAKEFYRRAKQYRSSGIWKVSRDEFCRLLNVSKSTSDSVSNLNRVVLKPIVEECGPLLGLKIERQYAKRRLSGFVFTFARETPPVIDARPVKAKEEQDSGHWTSVAGYGEVFTTTELFDVTAARDHFDGTVDAGECRYCRYDARNRERHARNAGTLF

Protein

Gene

rep

Protein

Replication-associated protein

Organism

Goose circovirus

Length

293 amino acids

Function

Similarity

Belongs to the nanoviruses/circoviruses replication-associated protein family.

Mass

33.842 kDa

Sequence

MAKNGNYSYKRWVFTINNPTFEDYCAVVEFCNLDNCKFAIVGEEKGEKEGTPHLQGFLSLRKNAKAAALEENLGGRAWLSRARGSDEDNEEYCSKESTYLRVGEPNRKGRSSDLPDAASDVLAGLPITDVARKYPTTYVMFGRGLERLRQLIVETARDWKTEVIVLIGRPGSGKSRYAFEFPAREKYYKSRGKWWDGYNGQDVVVMDDFYGWLPYDDLLRICDRYPLRVEYKGGMTQFVAKTLIITSNREPRDWYKCEFDVSALYRRINQYLILTPDGYAPAPEFMLPFKINY

Protein

Replication-associated protein: rep

Gene

Rep

Protein

Replication-associated protein

Organism

Canary circovirus

Length

290 amino acids

Function

Similarity

Belongs to the nanoviruses/circoviruses replication-associated protein family.

Mass

33.372 kDa

Sequence

MAPVRAAAAKRWCFTLNNYTAEEEAKVRALLPGEFHFAICGKERGEQGTPHLQGFLHFKKKQRLSALKKLLARAHWEKARGSDHDNEEYCSKENDVILTIGEPVQGNRSDLAGAVAAVKAGRRMVDIAREFSEIYVKYGRGLRDLALMIGQKPRDFKTEVVVITGPSGVGKSRLASEMEGSKFYKMKGDWWDGYSNEDIVIMDDFYGWLPFCEMLRLMDRYPHKVPVKGSYVEFTSKKIVITSNTHPESWYCPDKCYLPALFRRINKWMYWDGLRFEDVPDAMKKHPINY

Protein

Gene

Rep

Protein

Replication-associated protein

Organism

Beak and feather disease virus

Length

289 amino acids

Function

Similarity

Belongs to the nanoviruses/circoviruses replication-associated protein family.

Mass

33.446 kDa

Sequence

MPSKEGSGCRRWCFTLNNPTDGEIEFVRSLGPDEFYYAIVGREKGEQGTPHLQGYFHFKNKKRLSALKKLLPRAHFERAKGSDADNEKYCSKEGDVILTLGIVARDGHRAFDGAVAAVMSGRKMKEVAREFPEVYVRHGRGLHNLSLLVGSSPRDFKTEVDVIYGPPGCGKSRWANEQPGTKYYKMRGEWWDGYDGEDVVVLDDFYGWLPYCEMLRLCDRYPHKVPVKGAFVEFTSKRIIITSNKPPETWYKEDCDPKPLFRRFTRVWWYNVDKLEQVRPDFLAHPINY

Protein

Gene

Rep

Protein

Replication-associated protein

Organism

Human associated cyclovirus 1 (isolate Homo sapiens/Pakistan/PK5510/2007)

Length

280 amino acids

Function

Similarity

Belongs to the nanoviruses/circoviruses replication-associated protein family.

Mass

32.665 kDa

Sequence

MSNSTVRRFCFTWNNYTELNYALCQEFIKKYCKYGIVGKELAPTTNTPHLQGFCNLQKPMRFSTIKKRLDNGIHIEKSMGSDTQNQTYCSKSGEFFEAGDPQCQGKRNDLQSVVDTIQAGNGSLSSIANEHPTAYIRYFRGIQEYIKTVRPIPPRYHKTEVRYYHGPPGSGKSRRALEEATALASDLNDIYYKPRGTWWDGYKQQSCVIIDDFYGWIKYDEMLKICDRYPYKVQIKGGFEEFTSKYIWITSNIDTNLLYKFNDYNDTAFVRRIEIKLLIE

Protein

Gene

rep

Protein

Replicase polyprotein 1ab

Organism

Canine coronavirus (strain Insavc-1)

Length

168 amino acids

Function

Mass

18.98 kDa

Fragment

single

Sequence

PNTKSIDGENTSKDGFFTYVNGFIKEKLSLGGSAAIKITEFSWNKDLYELIQRFEYWTVFCTSVNTSSSEGFLIGVNYLGPYCDRAIVDGNIMHANYIFWRNSTIMALSHNSVLDTPKFKCRCNNALIVNLKEKELNEMVIGLLKKGKLLIRNNGKLLNFGNHLVNVP

Protein

Gene

rep

Protein

Replicase polyprotein 1ab

Organism

Porcine respiratory coronavirus (strain 86/137004 / isolate British)

Length

131 amino acids

Function

Mass

15.161 kDa

Fragment

single

Sequence

ITEFSWNKYLYELIQRFEYWTVFCTSVNTSSSEGFLIGVNYLGPYCDKAIVDGNIMHANYIFWRNSTIMALSHNSVLDTPKFKCRCNNALIVNLKEKELNEMVIGLLRKGKLLIRNNGKLLNFGNHFINTP

Protein