Organism
Catharanthus roseus
Function
Component of iboga and aspidosperma monoterpenoid indole alkaloids (MIAs, e.g. tabersonine and catharanthine) biosynthesis pathway from 19E-geissoschizine. Catalyzes the second oxidation step of the unstable intermediate product resulting from the reaction triggered by the geissoschizine oxidase (GO) in the stemmadenine biosynthesis process from 19E-geissoschizine.
Similarity
Belongs to the aldo/keto reductase family.
Sequence
MEKQVEIPEVELNSGHKMPIVGYGTCVPEPMPPLEELTAIFLDAIKVGYRHFDTASSYGTEEALGKAIAEAINSGLVKSREEFFISCKLWIEDADHDLILPALNQSLQILGVDYLDLYMIHMPVRVRKGAPMFNYSKEDFLPFDIQGTWKAMEECSKQGLAKSIGVSNYSVEKLTKLLETSTIPPAVNQVEMNVAWQQRKLLPFCKEKNIHITSWSPLLSYGVAWGSNAVMENPVLQQIAASKGKTVAQVALRWIYEQGASLITRTSNKDRMFENVQIFDWELSKEELDQIHEIPQRRGTLGEEFMHPEGPIKSPEELWDGDL