Protein
Velvet complex subunit RYP3
Organism
Ajellomyces capsulatus
Function
Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination (By similarity). The velvet complex acts as a global regulator for secondary metabolite gene expression (By similarity). Component of the RYP2-RYP3 heterodimeric complex that plays a dual role in activating genes associated with spore maturation and repressing certain development-associated genes (By similarity). The complex binds DNA through the DNA-binding domain of RYP2 that recognizes an 11-nucleotide consensus sequence 5'-CTGGCCGCGGC-3' consisting of two motifs in the promoters of key developmental regulatory genes (By similarity). Required for viable spore production and regulation of sporulation in response to temperature, as well as for the switch to yeast-form in the presence of host cells (PubMed:18791067).
Similarity
Belongs to the velvet family. VelB subfamily.
Sequence
MYTLKQDRPHPVPPPPPLTMDHLQHGYSTNTPVTLPGIPEAARSVSTVYEGRIYSLDVVQQPIRARMCGFGDKDRRPLTPPPCIRLIVRDATTQKEIDINEIDTSFYVLTVDLWNAEGTSEVNLVRHSATSPSISTATSSAYPPPANIMPFPQYAQTHGYPQTAYPPYYGGQPGYNPHAGYQYPQGGPDPYYPGLPAASTYYPPGTPTQALGPQSALGPHISSASTGMFTRNLIGSLSASAFRLTDPDDKIGVWFVLQDLSVRTEGSFRLKMNFVNVGTQSQAQDQSPGGTPSSPVINVGSAPVLASAFSEVFQVYSAKKFPGVIESTPLSKCFAFQGIKIPIRKDGVKGPRGGQSHGSKGQDGEGEDWENEG