Protein
RuvB-like helicase 1
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Function
DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity).
Similarity
Belongs to the RuvB family.
Sequence
MVQISEVQEQSSTAYTRTAAHTHIKGLGLDEFGVAKQVEGGFVGQAEAREACGVIVDLIKAKKMSGKAILLAGGPSTGKTALALAISQELGPKVPFCPLVGSELYSVEVKKTEALMENFRRAIGLRIKETKEVYEGEVTELTPEEAENPLGGYGKTISHVIVGLKSAKGTKTLRLDPTIYESIQREKVSVGDVIYIESNTGAVKRVGRSDAFATEFDLEAEEYVPLPKGEVHKKKEIVQDVTLHDLDVANARPQGGQDVISMMGQLMKPKKTEITEKLRHEVNKVVAKYIDQGVAELVPGVLFIDEVNMLDIEIFTYLNRALESDIAPVVVLASNRGMITVRGTDDVVSPHGVPPDLIDRLLIVRTLPYNREEIKTIISKRAAVENLQVEDEALEFLATLGTETSLRYVLQLLSPSGIIAKIANRAEISVADVEEAKLLFLDAKRSTKILEQSENYL