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RTN4IP1

Gene
RTN4IP1
Protein
Reticulon-4-interacting protein 1, mitochondrial
Organism
Bos taurus
Length
396 amino acids
Function
Plays a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve. Appears to be a potent inhibitor of regeneration following spinal cord injury.
Similarity
Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
Mass
43.583 kDa
Sequence
MGFLKTCVFRRNACTAVCFWRSQVVQKPSVRKISTTSPRSTVMPAWVIDKYGSNEVLRFTQNMMIPMIHYPNEVIIKVHAASINPIDVNMRSGYGATALNMKRDPLHVKIKGEEFPLTLGRDVSGVVMECGLDVRYFKPGDEVWAAVPPWKQGTLSEFVVVSGNEVSHKPRSLTHTQAASLPYVALTAWSAINKVGGLNDRNCTGKRVLILGASGGVGTFAIQVMKAWDAHVTAVCSQDASELVRKLGADDVIDYKSGNVEAQLKSSKPFDFILDNVGGSTETWALKFLKKWSGATYVTLVTPFLLNMDRLGIADGMLQTGVTVGSKTLKHFWQGVHYRWAFFMASGPCLDDIAELVEAGKIQPVIEKTFPFSKVPEAFLKVERGHARGKTVINVV

Gene
RTN4IP1
Protein
Reticulon-4-interacting protein 1, mitochondrial
Organism
Homo sapiens
Length
396 amino acids
Function
Plays a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve. Appears to be a potent inhibitor of regeneration following spinal cord injury.
Similarity
Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
Mass
43.59 kDa
Sequence
MEFLKTCVLRRNACTAVCFWRSKVVQKPSVRRISTTSPRSTVMPAWVIDKYGKNEVLRFTQNMMMPIIHYPNEVIVKVHAASVNPIDVNMRSGYGATALNMKRDPLHVKIKGEEFPLTLGRDVSGVVMECGLDVKYFKPGDEVWAAVPPWKQGTLSEFVVVSGNEVSHKPKSLTHTQAASLPYVALTAWSAINKVGGLNDKNCTGKRVLILGASGGVGTFAIQVMKAWDAHVTAVCSQDASELVRKLGADDVIDYKSGSVEEQLKSLKPFDFILDNVGGSTETWAPDFLKKWSGATYVTLVTPFLLNMDRLGIADGMLQTGVTVGSKALKHFWKGVHYRWAFFMASGPCLDDIAELVDAGKIRPVIEQTFPFSKVPEAFLKVERGHARGKTVINVV

Gene
Rtn4ip1
Protein
Reticulon-4-interacting protein 1, mitochondrial
Organism
Mus musculus
Length
396 amino acids
Function
Plays a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve (PubMed:26593267). Appears to be a potent inhibitor of regeneration following spinal cord injury (PubMed:12067236).
Similarity
Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
Mass
43.371 kDa
Sequence
MGVLKTCVLRRSACAAACFWRRTVIPKPPFRGISTTSARSTVMPAWVIDKYGKNEVLRFTQNMMLPIIHYPNEVIIKVHAASVNPIDVNMRSGYGATALNMKRDPLHMKTKGEEFPLTLGRDVSGVVMECGLDVKYFQPGDEVWAAVPPWKQGTLSEFVVVSGNEVSHKPKSLTHTQAASLPYVALTAWSAINKVGGLSDKNCKGKRALILGASGGVGTFAIQVMKAWGAHVTAVCSKDASELVRKLGADEVIDYTLGSVEEQLKSLKLFDFILDNVGGSTETWALNFLKKWSGATYVTLVTPFLLNMDRLGVADGMLQTGVTVGTKALKHLWQGVHYRWAFFMASGPYLDEIAELVDAGKIRPVIERTFPFSEVPEAFLKVERGHARGKTVVNVV

Gene
rtn4ip1
Protein
Reticulon-4-interacting protein 1 homolog, mitochondrial
Organism
Danio rerio
Length
387 amino acids
Function
Plays a role in the regulation of retinal ganglion cell (RGC) maturation, neurite outgrowth, and hence in the development of the inner retina and optic nerve (PubMed:26593267). Appears to be a potent inhibitor of regeneration following spinal cord injury (By similarity).
Similarity
Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
Mass
42.328 kDa
Sequence
MLMCRRWLVCSLRCHYRSFSFSAARRTVMPAWVIDKYGKNDVLRFTKNAALPIIHYPNEVVVKVHAAGLNPIDISMRGGYGAATMAMKRDPLNISQSGGEFPLILGRDVSGEIMECGLDVKYFKPGDQVWAAIPPWKQGSLAEFVVVSGNEVSHKPKSLRHDEAASIPYVAATAWSAIVNTGGLNKDNSAKKRVLILGGSGGVGTFAIQMVKAWGAHVTVTCSQNAERLVRDLGADDVVDYTAGPVEKQLKNLEKFDLILDSIGGETEKWALDLLKPWSGAKFVTLITPFLQNTDRLGLADGMMQSAVTVGCKVVKNLRKGVHYRWGFFAPSGSALDEVSEMVDAGKVRPVVEEVFSFAQVPEAFQKVEQGHARGKTVVSIMEDQKE

Gene
rtn4ip1
Protein
Reticulon-4-interacting protein 1 homolog, mitochondrial
Organism
Dictyostelium discoideum
Length
352 amino acids
Similarity
Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
Mass
39.332 kDa
Sequence
MKGILLNGYGESLDLLEYKTDLPVPKPIKSQVLIKIHSTSINPLDNVMRKGYASSIVDLKLKLPIILGRECSGEIVEIGDSVWDYEIGDQVWSASPPFSMGSHCEYITVDESEISLKPKNLTHQQSASIPFASLTAWNAIYNVLPTNKKITTNTKILVNGGNGSVGFFILQLLKKHLNVNQVSTTCNIKHFEKLKKLTLVNETIDYNNLKINDNDNNKFDLIFNCYDGGKNQNENEKKCIDALKDGGNLIGFNGPLVKFSDKDGVLSGLPMGMMNQLNSSERIKKQYSKNVHLDYAIFSPSGSTLKQISKLYENNILIPNIDKQFNLNQIKDAYTCFENSNSNGKIIINNKF