Rreb1

Ras-responsive element-binding protein 1

1700 amino acids

Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters. May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression. Represses the angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1 (By similarity). Binds specifically to the allelic variant of the CDKN2A promoter present in Balb/c mice, which leads to a down-regulation of CDKN2A expression in this strain, and, as a consequence, to an elevated susceptibility to pristane-induced tumors.

Belongs to the krueppel C2H2-type zinc-finger protein family.

184.154 kDa

MTSNSPIGLEGSDLSSINTMMSAVMSVASVTENGGSPQGIKSPMKPPGPNRIGRRNQETKEEKSSYNCPLCEKICTTQHQLTMHIRQHNTDTGGADHACSICGKSLSSASSLDRHMLVHSGERPYKCTVCGQSFTTNGNMHRHMKIHEKDTNSTTAAAPPSPLKRRRLSSKRKLSHDAESEDPGPAKKMVEDGQSGDLDKMSDEIFHCPVCFKEFVCKYELETHMETHSDNPLRCDICCVTFRTHRGLLRHNALVHKQLPRDAMGRPFIQNNPSIPAGFHDLGFTDFSCRKFPRISQAWCETNLRRCISEQHRFVCDTCDKAFPMLSSLILHRQSHIPADQGREKLQTKTLAAESLEQKAFLALLGLQHTKDVKPAPAEELLPDDNQAIQLQTLKYQLPQEPGCPTVLSVSPLDAASLGGSLTVLPATKENMKHLSLQPFQKGFIIQPDSSIVVKPISGESAIELADIQQILKMAASAPPQISLPPLSKAPATPLQAIFKHMPPLKPKPLVTPRTVVAASTPPPLINAQQASPGCISPSLPPQSLKFLKGSVEAVSNVHLLQSKSGIQPSTTTQLFLQQAGVELPGQPEMKTQLEQESIIEALLPLNMEAKIKQEITEGDLKAIMTGPSGKKTPAMRKVLYPCRFCNQVFAFSGVLRAHVRSHLGISPYQCNICDYIAADKAALIRHIRTHSGERPYICKICHYPFTVKANCERHLRKKHLKATRKDIEKNIEYVSSPTAELVDAFCAPETVCRLCGEDLKHYRALRIHMRTHCSRGLGGCHKGRKPFECKECNAPFVAKRNCIHHILKQHLHVPEKDIESYVLATNSGLGPADTPTDAASRGEEGSCVTFAECKPLATFLEPQNGFLHSSPTQPLPSHISVKLEPASSFAMDFNEPLDFSQKGLALVQVKQENVSSLLTSSSSSALYDCSMEPIDLSIPKSVKKGDKDTVVPSDAKKPEPEAGQAEPLSPRPPPCPTLSVTVEPKGSLETPTGTVVAVTTAAKLEPHTQPLQGSVQLAVPIYSPALVSNTPLLGNSAALLNNPALLRPLRPKPPLLLPKPSMTEELPPLASIAQIISSVSSAPTLLKTKVADPGPSITSSNTVATDSPGSSIPKAAATPTDTTSSKESSEPPPAASSPEEALPTEQGPAATSSSRKRGRKRGLRNRPLPNSSAVDLDSSGEFASIEKMLATTDTNKFSPFLQTAEDDTQEEVAGAPADQHGPADEEQGSPAEDRLLRAKRNSYANCLQKINCPHCPRVFPWASSLQRHMLTHTDSQSDTDTLTTPGEVLDLTAQAKEQPPAEGASEISPASQDLAIKEAKAAAAPSEEEEEKETEENPEPEEECRVEESTGAADAPEEDTASNQSLDLDFATKLMDFKLAESEAGSVDSQGPAQQEPKHACDTCGKNFKFLGTLSRHKKAHSCQEPKEEEAAAPSLENEGVGRAVEGPSPSPEPEEKPAESLAIDPTPGTREASVAKQNEETEGPTDGEGTAEKRGDGDKRPKTDSPKSMASKADKRKKVCSVCNKRFWSLQDLTRHMRSHTGERPYKCQTCERTFTLKHSLVRHQRIHQKARHSKHHGKDSDKDERAEEDSEDESTHSATNPASENEAESAPSTSNHVAVTRSRKESLSTSGKECSPEERAAAEQAAEPSAPKEQASPGETDPQSPAAIVQDLLELCGKRPAPILAATDGASQLLGME

RREB1

Ras-responsive element-binding protein 1

1687 amino acids

Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters. May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression. Represses the angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1.

Belongs to the krueppel C2H2-type zinc-finger protein family.

181.42 kDa

MTSSSPAGLEGSDLSSINTMMSAVMSVGKVTENGGSPQGIKSPSKPPGPNRIGRRNQETKEEKSSYNCPLCEKICTTQHQLTMHIRQHNTDTGGADHSCSICGKSLSSASSLDRHMLVHSGERPYKCTVCGQSFTTNGNMHRHMKIHEKDPNSATATAPPSPLKRRRLSSKRKLSHDAESEREDPAPAKKMVEDGQSGDLEKKADEVFHCPVCFKEFVCKYGLETHMETHSDNPLRCDICCVTFRTHRGLLRHNALVHKQLPRDAMGRPFIQNNPSIPAGFHDLGFTDFSCRKFPRISQAWCETNLRRCISEQHRFVCDTCDKAFPMLCSLALHKQTHVAADQGQEKPQATPLPGDALDQKGFLALLGLQHTKDVRPAPAEEPLPDDNQAIQLQTLKCQLPQDPGCTNLLSLSPFEAASLGGSLTVLPATKDSIKHLSLQPFQKGFIIQPDSSIVVKPISGESAIELADIQQILKMAASAPPQISLPPFSKAPAAPLQAIFKHMPPLKPKPLVTPRTVVATSTPPPLINAQQASPGCISPSLPPPPLKLLKGSVEAASNAHLLQSKSGTQPHAATRLSLQQPRAELPGQPEMKTQLEQDSIIEALLPLSMEAKIKQEITEGELKAFMTAPGGKKTPAMRKVLYPCRFCNQVFAFSGVLRAHVRSHLGISPYQCNICDYIAADKAALIRHLRTHSGERPYICKICHYPFTVKANCERHLRKKHLKATRKDIEKNIEYVSSSAAELVDAFCAPDTVCRLCGEDLKHYRALRIHMRTHCGRGLGGGHKGRKPFECKECSAAFAAKRNCIHHILKQHLHVPEQDIESYVLAADGLGPAEAPAAEASGRGEDSGCAALGDCKPLTAFLEPQNGFLHRGPTQPPPPHVSIKLEPASSFAVDFNEPLDFSQKGLALVQVKQENISFLSPSSLVPYDCSMEPIDLSIPKNFRKGDKDLATPSEAKKPEEEAGSSEQPSPCPAPGPSLPVTLGPSGILESPMAPAPAATPEPPAQPLQGPVQLAVPIYSSALVSSPPLVGSSALLSGTALLRPLRPKPPLLLPKPPVTEELPPLASIAQIISSVSSAPTLLKTKVADPGPASTGSNTTASDSLGGSVPKAATTATPAATTSPKESSEPPAPASSPEAASPTEQGPAGTSKKRGRKRGMRSRPRANSGGVDLDSSGEFASIEKMLATTDTNKFSPFLQTAEDNTQDEVAGAPADHHGPSDEEQGSPPEDKLLRAKRNSYTNCLQKITCPHCPRVFPWASSLQRHMLTHTDSQSDAETAAAAGEVLDLTSRDREQPSEGATELRQVAGDAPVEQATAETASPVHREEHGRGESHEPEEEHGTEESTGDADGAEEDASSNQSLDLDFATKLMDFKLAEGDGEAGAGGAASQEQKLACDTCGKSFKFLGTLSRHRKAHGRQEPKDEKGDGASTAEEGPQPAPEQEEKPPETPAEVVESAPGAGEAPAEKLAEETEGPSDGESAAEKRSSEKSDDDKKPKTDSPKSVASKADKRKKVCSVCNKRFWSLQDLTRHMRSHTGERPYKCQTCERTFTLKHSLVRHQRIHQKARHAKHHGKDSDKEERGEEDSENESTHSGNNAVSENEAELAPNASNHMAVTRSRKEGLASATKDCSHREEKVTAGWPSEPGQGDLNPESPAALGQDLLEPRSKRPAHPILATADGASQLVGME

RREB1

Ras-responsive element-binding protein 1

1615 amino acids

Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters.

Belongs to the krueppel C2H2-type zinc-finger protein family.

178.389 kDa

MMSAVMNVGKIAENGGTSQTVKSPSKSPAPNRIGRRNQETKEEKSSYTCPLCEKICTTQHQLTMHIRQHNTDTGGTDHSCSICGKSLSSASSLDRHMLVHSGERPYKCSVCGQSFTTNGNMHRHMKIHEKDPNSTASTTPPSPLKAKRLSSKRKFSQDAEMDREERTPAKKVVEDGQYGEGDRKEDDAYHCPVCFKDFFCKYALESHMETHPDNSLRCDICCITFRTHRGLLRHNAVIHKQLPRDPTGKPFIQNNPSIPAGFHDLGFTDFSCRKFPRISQVWCETNLRRCISEFHRFICETCNKAFPMLLALKLHTETHVMDQGRDKHKLQSTSLPSENPDQKAFMASLGLQYTKDIKPVKQEDDTQDEVQEMRLRALKSNLPQEPGSTGLLSLSPLEAATMGGPFSVLPPTKENIKLLSLQPFQKGFIIQPDSSIVVKPISNESAIELADIQQILKMASSAPPQISLPPLSKAPSVPVQSIFKHMPPLKPKPLVTPRTVVATSTPPPLISAQQASPGCISPSLPPPPLRLIKNSVETSSNSHLSQPGAKSSPSSQLLLQPKVEPLTQHEMKTQLEQDSIIEALLPLNMEAKIKQEVTEGDLKAIIAGAANKKAPTMRKVLYPCRFCDQVFAFSGVLRAHIRSHLGISPYQCNICDYIAADKAALIRHLRTHSGERPYICKICHYPGTVKANCERHLRKKHLKVTRKDIEKNIEYVTSNAAEMVDAFCSPDTVCKLCGEDLKHYRALRIHMRTHSGCQKKKPFECKECGTAFSAKRNCIHHILKQHLHVQEREIENYILVVDCSAQESHTDAPLLEDSTYMDCKPITPFLEPQNGFLLGTSSHVPIKLEPMGNFPMDFDEPLDFSQKSKNLSAVQVKQENLLVSSPLSFYDCSMEPIDLSIPKVLKRDNDIPGEARNQELASSVITDNAYNWQQCPLGFGANGNSEKNRAVGHPQPLKGSLHLTVPIISPALLGNSALLRPLRPKPPPQPLLPKPPVTKELPPLASIAQIISSVSSAPALLKTEAADASPKAASSSTGCDKSGNAKAKMTIVTAIQRDSNLPSDLTQACDPEPSPIADTGLTKKRGRKKGTKNKPKLSSGVDLESSGEFASIEKMLATTDTNKFSPFLQSTDNFKEESGQNGTSEDEKETPEDKLLRGKRNTYSDCPQKITCPYCPRVFSWASSLQRHMLTHTDSQADTEAPATGGEVLDLTSCEKEQPEEVSELPGSECSPQEEQKADSPPAEEDAEEKADEYEEGPEEDSVSNKSLDLNFASKLMDFKLAESDQSAGSSSQTERKHACDVCGKTFKFAGALSRHKKAHIREDRKDERSSEDESKSIQDDAGAPSMQDSGLEQEESPMDLKVVESPLDCEATGKENEESESISEGEGTERKSTEKSSDDKIPKTDEAKSTAKADKRKKVCTVCNKRFWSLQDLTRHMRSHTGERPYKCQTCERTFTLKHSLVRHQRIHQKVKNTRNHGKESDKEETQSRCGEDSENESSHSGTNPISENECDFAGVVGSHPSGTRSRKESLVGAAKDVPCEEERPSGQGATADLVEPAKSTQKQPAKDQEPRGSSELERPSGFIQDLLEMHNKKSPMNHILASADSTPQLLGVE