Protein
25S rRNA (adenine-N(1))-methyltransferase
Organism
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)
Function
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of a conserved adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2.
Similarity
Belongs to the methyltransferase superfamily. RRP8 family.
Sequence
MFPVKGLSVSADKLKVEPGAIVGTAPAAPAPASAPAVSSSKPSKKRKRHGGDKDVNVDASNLVDLWEKVIEQKKEGVADGVKKHENKRLKKEHEGQGEKLSNSNNDGNQGERKNNKKKNKNKNKNQGEHGIQVAQKKGPKKVEGEEDEDDNNDDADEWEGIDEDEKHASSEKPTPKKDDKKQQQLQQQQQQKKQQKNQEKDNRNGTTSNWQQDKPQPKTATPAPKLTPLQASMREKLISARFRHLNETLYTRPSTEAFKLFEESPEMFTEYHEGFRRQVDVWPENPVDVYIKEIKERAKVRFAPKISGGAEGGKSLPPARFPLPRDQKTKVCTIADLGCGDAKLAKTLVPLKQKLRLEIHSFDLQTGGCELVTRADIANLPLPDNSVDLAIFCLALMGTNWLDFVEEAYRILRWRGELWVAEIKSRFAGSQARVKQPPQKKVVAHSVGKRKKGSALAVAEEEEGDPEQNNLDLAVHVDGDTSKLKKPHETDITAFVEALKRRGFLLNRDFGDNSVDMGNKMFVRMHFVKAAVPTRGKCVPKDGQEDTTKNKKGGQKPKPKFIEEKDEQEEVKDEAAVLKPCVYKIR