RPB2

DNA-directed RNA polymerase II subunit RPB2

1236 amino acids

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity).

Belongs to the RNA polymerase beta chain family.

140.115 kDa

MSDQASDPYMYDDDSSSITPEDCWTVISSFFQEKGLVSQQLDSFDEFIESTIQELVWEDSRLILDQPAQHTSEEDHENRRYEITFGKIYISKPTQTEGDGTTHPMFPQEARLRNLTYSSPLYVDMTKRVLKSDDNAGNEHELEWIEEEIKDEEPSTKVYLGKVPIMLRSKFCMLRDLGEHEFYELKECPYDMGGYFVINGSEKVLIAQERSAANIVQVFKKAAPSPISHVAEIRSALERGSRLISSMQIKLYGREEKSTSNRTIKATLPYIKEDIPIVIVFRALGIVPDGDILEHICYDANDWQMLEMLKPCVEEGFVIQEREVALDFIGRRGALGIKREKRIQYAKDILQKELLPNITQDEGFETRKAFFLGYMVNRLLLCALERKEPDDRDHFGKKRLDLAGPLLASLFRILFKKLTKDIYNYMQRCVENDKVFNLTLAVKSQTITDGLRYSLATGNWGEQKKAMSSRAGVSQVLNRYTYSSTLSHLRRTNTPIGRDGKIAKPRQLHNTHWGLVCPAETPEGQACGLVKNLSLMSCISVGTPSEPILYFLEEWGMEPLEDYVPSNSPDSTRVFVNGVWVGTHREPAHLVDTMRSLRRRGDISPEVSIIRDIREKEFKIFTDAGRVYRPLFIVDDDPESETKGELKLQKEHIHKLLNAEYSEEYATNEFGEEEGPYGWSSLVNDGVVEYVDAEEEETIMIAMTPEDLEASKSSLTATQQKSLQLEEQELDPAKRIKPTNSSTTSTFTHCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNYSVRMDTMANILYYPQKPLATTRAMEHLKFRELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLFFRTYMDLEKRQGMKALETFEKPSRSDTLRLKHGTYEKLDDDGLIAPGIRVSGEDIIIGKTTPIPPDTEELGQRTQYHTKRDASTPLRSTESGIVDQVLLTTNGDGAKFVKVRMRTTKVPQIGDKFASRHGQKGTVGVTYRHEDMPFTSQGIVPDLIINPHAIPSRMTVAHLIECLLSKVSSLSGLEGDASPFTDVTAEAVSKLLREHGYQSRGFEVMYHGHTGKKLMAQVFFGPTYYQRLRHMVDDKIHARARGPVQVLTRQPVEGRSRDGGLRFGEMERDCMIAHGAAGFLKERLMEASDAFRVHVCGVCGLMSVIANLKKNQFECRSCKNKTNIYQIHIPYAAKLLFQELMAMNISPRLYTERSGVSVRT

RPB2

DNA-directed RNA polymerase II subunit RPB2

1224 amino acids

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerases II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. During a transcription cycle, Pol II, general transcription factors and the Mediator complex assemble as the preinitiation complex (PIC) at the promoter. 11-15 base pairs of DNA surrounding the transcription start site are melted and the single-stranded DNA template strand of the promoter is positioned deeply within the central active site cleft of Pol II to form the open complex. After synthesis of about 30 bases of RNA, Pol II releases its contacts with the core promoter and the rest of the transcription machinery (promoter clearance) and enters the stage of transcription elongation in which it moves on the template as the transcript elongates. Pol II appears to oscillate between inactive and active conformations at each step of nucleotide addition. Pol II is composed of mobile elements that move relative to each other. The core element with the central large cleft comprises RPB3, RBP10, RPB11, RPB12 and regions of RPB1 and RPB2 forming the active center. The clamp element (portions of RPB1, RPB2 and RPB3) is connected to the core through a set of flexible switches and moves to open and close the cleft. The cleft is surrounded by jaws: an upper jaw formed by portions of RBP1, RPB2 and RPB9, and a lower jaw. The jaws are thought to grab the incoming DNA template. The fork loop 1 (RPB2) interacts with the RNA-DNA hybrid, possibly stabilizing it.

Belongs to the RNA polymerase beta chain family.

138.751 kDa

MSDLANSEKYYDEDPYGFEDESAPITAEDSWAVISAFFREKGLVSQQLDSFNQFVDYTLQDIICEDSTLILEQLAQHTTESDNISRKYEISFGKIYVTKPMVNESDGVTHALYPQEARLRNLTYSSGLFVDVKKRTYEAIDVPGRELKYELIAEESEDDSESGKVFIGRLPIMLRSKNCYLSEATESDLYKLKECPFDMGGYFIINGSEKVLIAQERSAGNIVQVFKKAAPSPISHVAEIRSALEKGSRFISTLQVKLYGREGSSARTIKATLPYIKQDIPIVIIFRALGIIPDGEILEHICYDVNDWQMLEMLKPCVEDGFVIQDRETALDFIGRRGTALGIKKEKRIQYAKDILQKEFLPHITQLEGFESRKAFFLGYMINRLLLCALDRKDQDDRDHFGKKRLDLAGPLLAQLFKTLFKKLTKDIFRYMQRTVEEAHDFNMKLAINAKTITSGLKYALATGNWGEQKKAMSSRAGVSQVLNRYTYSSTLSHLRRTNTPIGRDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNLSLMSCISVGTDPMPIITFLSEWGMEPLEDYVPHQSPDATRVFVNGVWHGVHRNPARLMETLRTLRRKGDINPEVSMIRDIREKELKIFTDAGRVYRPLFIVEDDESLGHKELKVRKGHIAKLMATEYQDIEGGFEDVEEYTWSSLLNEGLVEYIDAEEEESILIAMQPEDLEPAEANEENDLDVDPAKRIRVSHHATTFTHCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILYYPQKPLGTTRAMEYLKFRELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLFFRSYMDQEKKYGMSITETFEKPQRTNTLRMKHGTYDKLDDDGLIAPGVRVSGEDVIIGKTTPISPDEEELGQRTAYHSKRDASTPLRSTENGIVDQVLVTTNQDGLKFVKVRVRTTKIPQIGDKFASRHGQKGTIGITYRREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAALSGNEGDASPFTDITVEGISKLLREHGYQSRGFEVMYNGHTGKKLMAQIFFGPTYYQRLRHMVDDKIHARARGPMQVLTRQPVEGRSRDGGLRFGEMERDCMIAHGAASFLKERLMEASDAFRVHICGICGLMTVIAKLNHNQFECKGCDNKIDIYQIHIPYAAKLLFQELMAMNITPRLYTDRSRDF

RPB2

DNA-directed RNA polymerase II subunit RPB2

1223 amino acids

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity).

Belongs to the RNA polymerase beta chain family.

138.714 kDa

MSADNEDYYDEDPYGFEEENAPITAEDTWAVISAFFREKGLVSQQLDSFNQFVDYTLQDIISEDSTLILEQLAQHTTEQDNISRKYEISFGKIYVTKPMVNESDGVTHALYPQEARLRNLTYSSGLFVDVTKRTYEAVDVPGRDLNYQLIAEESEEDSESGKVFIGRLPIMLRSKNCYLSDATESDLYKLKECPFDMGGYFIINGSEKVLIAQERSAGNIVQVFKKAAPSPISHVAEIRSALEKGSRFISTLQVKLYGRESSSARTIKATLPYIKQDIPIVIIFRALGIIPDGEILEHICYDVNDWQMLEMLKPCVEDGFVIQDRETALDFIGRRGTALGIKKEKRIQYAKDILQKEFLPHITQLEGFESRKAFFLGYMINRLLLCALDRKDQDDRDHFGKKRLDLAGPLLAQLFKTLFRKLTKDIFRYMQRTVEEANDFNMKLAINAKTITSGLKYALATGNWGEQKKAMSSRAGVSQVLNRYTYSSTLSHLRRTNTPIGRDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNLSLMSCISVGADPMPIITFLSEWGMEPLEDYVPHQSPDATRVFVNGVWHGVHRNPARLMETLRTLRRKGDINPEVSMIRDIREQELKIFTDAGRVYRPLFIVEDDEELGRKELKVRKGHVAKLMATEYQDIEGGFEDAEDYTWSSLLNEGLVEYIDAEEEESILIAMQPEDLEPTAVEQDIPKENVDLAKRIKVTHHATTFTHCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNYNFRMDTMANILYYPQKPLGTTRAMEYLKFRELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLFFRSYMDQEKKYGMSITETFEKPQRTNTLRMKHGTYDKLDEDGLIAPGVRVSGEDIIIGKTTPIAPDEEELGQRTAYHSKRDASTPLRSTENGIVDQVLITTNQDGLKFVKVRVRTTKVPQIGDKFASRHGQKGTIGITYRREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAALSGNEGDASPFTDITVEGISKLLREHGYQSRGFEVMYNGHTGKKLMAQIFFGPTYYQRLRHMVDDKIHARARGPMQVLTRQPVEGRSRDGGLRFGEMERDCMIAHGAAAFLKERLMEASDAFRVHICGICGLMSVIAKLNHNQFECKGCDNKIDIYQIHIPYAAKLLFQELMAMNITPRLYTDRSRDF

RPB2

DNA-directed RNA polymerase II subunit RPB2

1222 amino acids

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity).

Belongs to the RNA polymerase beta chain family.

138.617 kDa

MLEYYDDDAYVYDDDDEDAPITAEDSWTVISAFFREKGLVSQQLDSFNQFINYTIQDLILEDSTLILEQLAQHTTEADNISRKYEISFGKIYLAKPSMTESDGVSHAMYPQEARLRNLTYASGLFVEIKKRTYEAVDIPGRDLKYEIIQEESEDTEEGKIFIGRVPIMLRSKYCLLDDLSESDLYRLKECPFDMGGYFIINGSEKVLIAQERSAGNIVQVFKKSAPSPISHIAEIRSALEKGSRFISTLQVKLYGREGSTSRTIKATLPYIKQDIPIVIIFRALGIIPDGEILEHICYDQNDWQMLEMLKPCVEEGFVIQDRETALDFIGRRGTALGIKKEKRIQYAKDILQKEFLPHITQLEGFESRKAFFLGYMINRLLLCALDRKDQDDRDHFGKKRLDLAGPLLAQLFKTLFRKLTRDILRFMQRSVEEAKDFNLKLAVKATTITAGLKYALATGNWGEQKKAMSSRAGVSQVLNRYTYSSTLSHLRRTNTPIGRDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNLSLMSCISVGTDPVPIITFLNEWGMEPLEDYVPHQSPDATRVFVNGVWHGIHRNPARLVDTIRKLRRKGDITAEVSIVRDIREKELKIFTDAGRVYRPLFVVADTQHADGHKDLKVRKGHIRKLMLTEYQDIEGGFEDEDINYTWTSLLNDGIVEYIDAEEEETILIAMQQEDLDPSVPQTVDPSDELDPARRIKAIHHSNTFTHCEIHPSMILGVAASVIPFPDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILYYPQKPLGTTRAMEYLKFRELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDSGLFRSLFFRSYMDQEKRIGMSITESFEKPHRTNTLRMKHGTYEKLDDDGLIAPGVRVSGDDIIIGKTTPIPPDAEELGQRTAFHSKRDASTPLRSTENGIVDQVLITTNQEGLKFVKVRVRTTKVPQIGDKFASRHGQKGTIGITYRREDMPFTAEGVVPDLIINPHAIPSRMTVAHLIECLLSKVAALSGNEGDASPFTDITVDGISKLLREHGYQSRGFEVMYNGHTGKKLMAQIFFGPTYYQRLRHMVDDKIHARARGPMQVLTRQPVEGRSRDGGLRFGEMERDCMIAHGAAAFLKERLMEASDAFRVHICGICGLMTVVAKLKHNQFECRGCKNKIDIYQVHIPYAAKLLFQELMAMNIAPRLYTDRSRDF

rpb2

DNA-directed RNA polymerase II subunit RPB2

1210 amino acids

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity).

Belongs to the RNA polymerase beta chain family.

137.849 kDa

MSYEDYQYNETLTQEDCWTVISSFFEETSLARQQLFSFDEFVQNTMQEIVDDDSTLTLDQYAQHTGAQGDVTRRYEINFGQIYLSRPTMTEADGSTTTMFPQEARLRNLTYSSPLYVDMRKKVMVAADSNVPIGEEEWLVEEEDEEPSKVFIGKIPIMLRSTFCILNGVSDSELYDLNECPYDQGGYFIINGSEKVIIAQERSAANIVQVFKKAAPSPIAYVAEIRSALERGSRLISSMQIKLMARNTENSGQTIRATLPYIRSDIPIVIVFRALGVVPDRDILEHICYDPNDFQMLEMMKPCIEEAFVIQDKDIALDYIGKRGSTTGVTREKRLRYAHDILQKELLPHITTMEGFETRKAFFLGYMIHRMLLCALERREPDDRDHFGKKRLDLAGPLLASLFRMLFRKMTRDVYKYMQKCVETNREFNLTLAVKSNIITNGLRYSLATGNWGDQKRSMVNRVGVSQVLNRYTFASTLSHLRRTNTPIGRDGKLAKPRQLHNTHWGMVCPAETPEGQACGLVKNLSLMSYVSVGSPSAPIIEFLEEWGLETLEDYNPSASPNATKVFVNGVWLGVHRDPAHLTETLRSLRRRLDISAEVSIVRDIREKELRLFTDAGRICRPLFIVDNNPNSERRGELCIRKEHIQQLIEDKDRYDIDPEQRFGWTALVSSGLIEYLDAEEEETVMIAMSPEDLEASRQMQAGYEVKEELDPAQRVKPAPNPHVHAWTHCEIHPAMILGILASIIPFPDHNQSPRNTYQSAMGKQAMGVYLTNYQVRMDTMANILYYPQKPLATTRSMEYLKFRELPAGQNAIVAILCYSGYNQEDSIIMNQASIDRGLFRSIFYRTYTDQEKKIGMTVMEEFERPVRSTTLRMKHGTYDKLEDDGLIAPGTRVSGEDIIIGKTAPIPLDHEELGQRTQLHAKRDVSTPLRSTESGIVDQVMVTTNQEGLKFVKVRMRSTRIPQIGDKFASRHGQKGTIGMTYRHEDMPFSAQGIVPDIIINPHAIPSRMTVAHLVECQLSKVSALSGFEGDATPFTDVTVEAVSKLLRSHGFQSRGFEVMYHGHTGRKLVAQVFLGPTYYQRLKHLVDDKIHARARGPVQILTRQPVEGRSRDGGLRFGEMERDCQISHGCSSVLRERLFDCSDAYRVIVCDICGLIAIASYKKDSYECRSCQNRTRFSQVYLPYAAKLLFQELMSMNIAPRLFTKNHK

RPB2

DNA-directed RNA polymerase II subunit RPB2

1191 amino acids

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity).

Belongs to the RNA polymerase beta chain family.

135.064 kDa

MDMEDEYEPQYNVDDDEEEITQEDAWAVISAYFEEKGLVRQQLDSFDEFIQNTMQEIVDESADIEIRPESQHNPGHQSDFAETIYKINFGQIYLSKPMMTESDGETATLFPKAARLRNLTYSAPLYVDVTKRVIKKGHDGEEVTETQDFTKVFIGKVPIMLRSSYCTLYQNSEKDLTELGECPLDQGGYFIINGSEKVLIAQEKMSTNHVYVFKKRQPNKYAFVAEVRSMADTQNRPPSTMFVRMLSRTSAKGGSSGQYIRATLPYIRTEIPIIIVFRALGFVADKDILEHICYDFNDTQMMELLRPSLEEAFVIQNQQVALDYIGKRGATVGVTREKRIKYAKEILQKEMLPHVGVGEYCETKKAYYFGYIIHRLLLCALGRRAEDDRDHYGNKRLDLAGPLLGGLFRMLFRKLTRDVRGYVQKCVDNGKDVNLQFAIKAKTITSGLKYSLATGNWGQANAAGTRAGVSQVLNRLTYASTLSHLRRLNSPIGREGKLAKPRQLHNSQWGMMCPAETPEGQACGLVKNLALMVYITVGSAAYPILEFLEEWGTENFEEISPAVIPQATKIFVNGTWVGIHRDPDMLVRTLRRLRRRVDVNTEVGVVRDIRLKELRIYTDYGRCSRPLFIVEKQRLMIKKKDIQTLQQRESPDEGGWHDLVAKGYIEYIDTEEEETTMISMTINDLVQARLNPGDAYSDTYTHCEIHPSLILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGIYVTNYQFRMDTLAYVLYYPQKPLVTTRAMEHLHFRQLPAGINAIVAISCYSGYNQEDSVIMNQSSIDRGFFRSLFFRSYRDEEKKMGTLVKEDFGRPDRASTMGMRHGSYDKLDDDGLAPPGTRVSGEDVIIGKTTPISQDDAQGQASRYTRKDHSTSLRHSETGMVDQVLLTTNADGLRFVKVRVRSVRIPQIGDKFSSRHGQKGTVGMTYTQEDMPWTVEGITPDIIVNPHAIPSRMTIGQLIECIMGKVAAHMGKEGDATPFTDVTVDNISKALHKCGYQMRGFETMYNGHTGRRLSAMIFLGPTYYQRLKHMVDDKIHSRGRGPVQILTRQPAEGRSRDGGLRFGEMERDCMIAHGAAHFLKERLFDQSDAYRVHVCERCGLIAIANLKKNSFECRGCKNKTDIVQVHIPYACKLLFQELMAMAIAPRMLTKDVKLAKDQKKKGA

RPB2

DNA-directed RNA polymerase II subunit RPB2

1141 amino acids

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity).

Belongs to the RNA polymerase beta chain family.

127.881 kDa

MESAFTKEHSWSIISSFFEQKGLVRQQLDSFDQFVKTKMQEVINESPVIIVQSAPTAGIETQKRIAVRFGQIYVSKPPVYTESDGRTITVFPNEARIRDLTYASPLFIDVTKETLSELGVVDKHKYSRVPFGSLPVMLRSSYCVLYGLGDKDLIDLGECPYDQGGYFIVNGSEKVIVAQERMASNTVYVFKKAQPATYTHYAEIRSVPEKSSRNPSTLSMKLCRSPGVIRVSLPLVKQDVPLFVLYRALGFLSDKEIIDHILYEDDEEMFELLKESIEEGTVVQDQNVALDYIGKRSAPIGTPQEKRIVMAKDLLAKEVLPHIGTQEFCETKKAYFIGYIVQRLLLVALGRRNPDDRDHYGKKRMDLSGPLLASLFRTLFKKLCVDTTRHMQKCIENGREFNIALGLKASIITQGFRYALATGNWGDQAKAMQTRAGVAQVLNRYNFVSTLSHLRRVNTPIEKEGKLAAPRQLHNTHWGMVCPAETPEGQACGLVKNLSLMAYISVGSSSGPLVEFLEECGVESLEEISTSQLDAATKIFVNGVWVGIHSDPVGLIKSLKLLRRSLEMDKEVSIVRDIREKEIRVQSDAGRPCRPLLVVKDNKLVITAEDIRKLKRGEIKWDNLVTSGFIEFLDVEEEEMSMIAMNTKILADESRNSSDVSVSYTHCEIHPALILGICASTIPFPDHNQSPRNTYQSAMGKQAMGIYATNFLLRMDTLSNILFYPQKPLVTTKSMEYLRFKELPSGQNALVAIACYSGYNQEDSIIMNQSAIDRGLFRSFFYRTYTDQESMSRPGVNEEFCKPSRGAVLRMKNLNYNKLDDDGLISPGTRVTGDDVLIGKITPILDPERSTKEAPVYVYKDSSTAMRRTETGIVDTVIVTNKDGYKFSKVKVRSGRIPQMGDKFASRHAQKGTIGITLRQEDMPFTSEGIVPDIIINPHAIPSRMTIGHLIECLLGKVSAMSGEEGDATPFSGVTVDGISSRLKSYGFQQRGLEVMYNGMTGRKLRAQMFFGPTYYQRLKHMVDDKIHARARGPLQILTRQPVEGRSRDGGLRFGEMERDCIISHGASAFLKERLMDVSDAYSCYVCDFCGLLAMGGSKVNECKGCNNTTNVSMVEIPYAFKLLIQELMGMNIAPRIRFEE