Protein
Rhomboid-like protease 5
Organism
Toxoplasma gondii
Function
Serine protease involved in intramembrane proteolysis. Cleaves microneme adhesins, such as MIC2. This step is essential for efficient invasion of host cells. Catalyzes intramembrane proteolysis of AMA1.
Similarity
Belongs to the peptidase S54 family.
Sequence
MSSKGGSSRLGSKDLKKMTSRTERELRDSGRVRGEVERVEKRLRATAKVKEQPPTGDYKRRALASPGETAAPTFLVDSRGIPRKTSSTAPRKATLRPASSSPRLASSSRPTESTLPSSSSRALQGASSSSSSRPRRLHESASGRGGSGGSAGELRQEKKRLPELEAAEAAPASCVVELRDVTARKGRTSPATPPETAGSSVCGQGSHARTAEKLEEGTASHRDGSRRGSVDAETWATPGDGSSSHEFESSPQREERMQPQETGRRELSSEPRSGDLTKNGGDGGPRRHSCAWRKWREHMIQSFDITTHPFPPRGDGSPRRGKFLMIFLTSSVLFFVFLQELVLNVTTFNGRCMSPVLYPSHDAPESERTPRVISFGYGACEHNLGVSLFRREETKKDPRGRWTPGPLTERCASGRCASDDGWPSDLVQRGRAQRSPAAFDSPNPRVFSSLGALDTNKVRNYGEMFRVVWGMFLHGGWMHLLLNVSCQAQTLWILEPAWGFLRTLSLWIVGGVSGSLLSAVANPCTVTVGSSGAFYGLLGALVPFSIEYWDHIASPAWFLFCVSVLVMVAQFGNMVGVQGVDNNAHLGGLIGGLLFGFATIRSVHAFRWQGVAERMASSTLFWWMFPAEKRRSLREDNLQRVAREREERSSGRIPPPKFVWKFRGHEREWCVRFAAAVGLVTFWSVLWLYLLVPSYYESLSSPPGNFSFLGSTGCHCCRVQPFPGEEDKLPAFHPVRVNRGLFWCFVSEGVANLFCGRSSALNRGADVYGQTRQFEEALGDLPSARAGEAPLRIAKEEGESASVWQRLVKSAKKTYNAVLGNTTTPAAPSAAELAQQTRAGQ