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RNF186

Gene
RNF186
Protein
E3 ubiquitin-protein ligase RNF186
Organism
Homo sapiens
Length
227 amino acids
Function
E3 ubiquitin protein ligase that is part of an apoptotic signaling pathway activated by endoplasmic reticulum stress (PubMed:23896122). In that process, stimulates the expression of proteins specific of the unfolded protein response (UPR), ubiquitinates BNIP1 and regulates its localization to the mitochondrion and induces calcium release from the endoplasmic reticulum that ultimately leads to cell apoptosis (PubMed:23896122).
Mass
24.145 kDa
Sequence
MACTKTLQQSQPISAGATTTTTAVAPAGGHSGSTECDLECLVCREPYSCPRLPKLLACQHAFCAICLKLLLCVQDNTWSITCPLCRKVTAVPGGLICSLRDHEAVVGQLAQPCTEVSLCPQGLVDPADLAAGHPSLVGEDGQDEVSANHVAARRLAAHLLLLALLIILIGPFIYPGVLRWVLTFIIALALLMSTLFCCLPSTRGSCWPSSRTLFCREQKHSHISSIA

Gene
RNF186
Protein
E3 ubiquitin-protein ligase RNF186
Organism
Bos taurus
Length
226 amino acids
Function
E3 ubiquitin protein ligase that is part of an apoptotic signaling pathway activated by endoplasmic reticulum stress. In that process, stimulates the expression of proteins specific of the unfolded protein response (UPR), ubiquitinates BNIP1 and regulates its localization to the mitochondrion and induces calcium release from the endoplasmic reticulum that ultimately leads to cell apoptosis.
Mass
24.378 kDa
Sequence
MACLEIPQQPQLVCQKATPSDPAGCDGGPGGPTEGDLECLVCREPYSGVRPPKLLGCQHAFCAVCLKLLLCVQDDAWSIPCPLCRKVTAVPGGLVCTLRDQEKVLERLARPGLEVPLRPQGLANPATLTAGQPREAGEEEQDAVTTNRAAARRLAAHLLLLVLLIILILPFIYPGVIRWVLSFLETLALLLALLFCSHPGQQDGCMPTPRTLFCRERKPSEIASIS

Gene
Rnf186
Protein
E3 ubiquitin-protein ligase RNF186
Organism
Mus musculus
Length
226 amino acids
Function
E3 ubiquitin protein ligase that is part of an apoptotic signaling pathway activated by endoplasmic reticulum stress. In that process, stimulates the expression of proteins specific of the unfolded protein response (UPR), ubiquitinates BNIP1 and regulates its localization to the mitochondrion and induces calcium release from the endoplasmic reticulum that ultimately leads to cell apoptosis.
Mass
24.704 kDa
Sequence
MSCTEAPQPIPAGTTTTSTIIALGPTGRLSISVEGDLECLVCREPYNCARSPKLLSCQHTFCAVCLKLLLYVQEDTWSIPCPLCRKVTAVPGGLICSLRDQEAMVGRLALPCPEVRLCPQRLVGSAASATRPANWTGEEEQDTVSVNRVAARRLAVHLLLLALVIVLILPFIYPGVIRWVLAFVIALALLMSTLFCCHPQSQNSNWLCPRTLFCREQKQTQITSIA