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RNF169

Gene
RNF169
Protein
E3 ubiquitin-protein ligase RNF169
Organism
Homo sapiens
Length
708 amino acids
Function
Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair.
Similarity
Belongs to the RNF169 family.
Mass
77.194 kDa
Sequence
MAAAGPSTRASSAAAAAALSRRGRRGRCDETAAAKTGAPGPASGPSLLVLSPPLLQPPLPPRPEESGCAGCLEPPGEAAALPCGHSLCRGCAQRAADAAGPGCPRCRARGPGWARRRARDDGQADSEVLGECARRSQPERCRPRRDGGAAAAGPRPEQEPRAAPAEPDFIFRAPIKLSKPGELREEYESLRKLREEKLQEEKPSEDQIHKLLPEDTETGKRKMDEQKKRDEPLVLKTNLERCPARLSDSENEEPSRGQMTQTHRSAFVSKNNSYSLAFLAGKLNSKVERSQSCSDTAQERAKSRVRAVPGNKAKVTTMTPASNPIIGVLLSTQNNRCVSAPDLTIEKRLPFSSLSSLASLHKPERSVSPESNDSISEELNHFKPIVCSPCTPPKRLPDGRVLSPLIIKSTPRNLNRSLQKQTSYEASPRILKKWEQIFQERQIKKTLSKATLTSLAPEMGEELLGSEGIHSSKEKPLVAVNTRLSGGQVLSEYTGPTSADLDHFPSVSQTKAEQDSDNKSSTEIPLETCCSSELKGGGSGTSLEREQFEGLGSTPDAKLDKTCISRAMKITTVNSVLPQNSVLGGVLKTKQQLKTLNHFDLTNGVLVESLSEEPLPSLRRGRKRHCKTKHLEQNGSLKKLRQTSGEVGLAPTDPVLREMEQKLQQEEEDRQLALQLQRMFDNERRTVSRRKGSVDQYLLRSSNMAGAK

Gene
Rnf169
Protein
E3 ubiquitin-protein ligase RNF169
Organism
Mus musculus
Length
694 amino acids
Function
Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair.
Similarity
Belongs to the RNF169 family.
Mass
75.796 kDa
Sequence
MAAAGPSTRASSAAAAAALSRRGRRGRCDEMAAAKAGAPGPASSPALLVLRSAPRPEESGCTGCLETPGEVAALPCSHSRCRGCASRAAGPGCRRCRPRGSGWARRRARDDGQAAAELMGERARRGQPEPCRPRRDGGAAASGPRPEPEPLAEPEFIFRTPIKLSKPGELSEEYGCLRKLRGEKLQEEKDCDDQIHKLLQEDSEMGKRKADEQKKRDEAVVLKTSLEQCPARLSDSENEEPSRGQMMQTHRSAFVSKNSSCSLAFLAGKLNTKVQRSQSCSDTVQDRVRSRLRTAPPNRAKITTITPGSTPIIGVLLSTQNNRCLSAPDLTIEKRLPFGSLSSLASLHKPERSISPESNDSISEELNHFKPIVCSPCTPPKRLPDGRVLSPLIIKSTPRNLTRSLQKQTSYEASPRILKKWEQIFQERQIKKTLSKATLTSLAPEAGEEFPGSDTIHSSKERPSLAFNTRLSRVQVLSECAGPTSTALECFPSVNQTKVEQDCVRKRSREFSLETCHSSEHGGASSGPSLEREQCEESGSTVDATLVKTCISTVMKTAAVNSLLPKNDVLGGVLKTKQQLKTLNHFDLGNGILVNSLGEEPIPSLRRGRKRRCKTKHLEQNGVKKLRPPSSDMDLAPKDPGLLEVGRKLQQEEEDQQLALQSHRMFDSERRTMSRRKGSVDQYLLRSSSLAGAK

Gene
RNF169
Protein
E3 ubiquitin-protein ligase RNF169
Organism
Bos taurus
Length
689 amino acids
Function
Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair.
Similarity
Belongs to the RNF169 family.
Mass
75.63 kDa
Sequence
MSGRAKVAGEEALVGVAAPQPVPAGILDECTNVTVSQPPSPPRPEESDCAGCLETPGEAAALPCGHSLCRGCAQRAADAAGPCCPRCRARGAGWARRRARDDWQADAEVLGERARRGPPERCRPRRDGGAAAAGPRPEQESRAAPAEPEFIFRAPIKLSKPGEFREEYESLRKLREEKLQEEKTSEDQIHKLLPEDTEIGKRKMDEQKKRDEPVVLKTNLEHCPARLSDSENEEPSRGKMIQTHRSAFVSKSSSYSLAFLAGNLNSKMERSQSCSDTGQDRAKSRLRAAPTSKAKATAMTPTSNPIIGVLLSTRNHRCLSAPDLTVEKRLPFSSLSALASLHKPERSISPESNDSISEELNHFKPIVCSPCTPPKRLPDGRVLSPLIIKSTPRNLNRSLQKQTSYEASPRILKKWEQIFQERQIKKTLSKATLTSLAPETGDDLLVSEVTQSNKEKPLLALNTRLSSGQVLSECTGPTAPDLDYFSSVSQTKAEQGSDRKKNTEIPLETCCSSELPVGASGTSLEREQSERSGSSPDAKLDKTRITASMKISAVNSVLPKNSVLGGVLKTKKQLKTVNHFDLPNGVLADNLGDEPLPSLRRGRKRRCKTKHLEQNGSLKKLRQSSGEVGLAPTDPVLREMEQKLQQEEEDRQLALQLQRMFDNERRTVSRRKGSVDQYLLRSSSMAGAK

Gene
rnf169
Protein
E3 ubiquitin-protein ligase RNF169
Organism
Danio rerio
Length
630 amino acids
Function
Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage.
Similarity
Belongs to the RNF169 family.
Mass
71.358 kDa
Sequence
MKMAAVGSAKSTGPGQRSKSRPGALSAPLSLEEARCPVCSEILLEPVTMPCGHSVCLHCFQRTVKLISLCCPLCRLRVSSWARKQSREKSLVNAELWELVRLSHPERCKRRMEQRDGEIPDGEIFRAPVPVHKVGEMRQEYEKQKMKSGRSEETDERKKKMHIKEECVLLKHCQYPFCGVSDSENEEPVGRRTRHVSAFVRKTRCSPAFNKSCLHSSAAQRSRSCTDSEDGRGKSRGHTNQAVPEKANIAHSYNAGILLSSENSRSFSAPLLSLDKRHHWRGIHTSSATLVLQTKPERSISPESNDSISEELNHFKPIVCSPCTPPKRLPDGRLLEPMIVKSTPRNLTRALHKSTSYEASPTILQKWKQIEVDRQCIKVTSKGTVTSPIAEDLNLKLSPVEERDCQPCSCSVAKDRLLDLQCICGSNAHKSKSRKDKPIIYNKRRLIFDPYNKGEEKTQVAALIKTFGDSSTPKACKELCEPSEMGPPMLDSNAGHCNQGTVDPDHNIKINEPTTMSCVLNRPTSRRGKKRSQKTKHMEETLQTKISRTNRYDSLDDLIVQRMSQEKEDRELALKLQRQFDRECKKVDRHKTSRNKYELRSWGSKDGIVGYNTRRSGRVSKQNEHFNYTC