About Products Protein Database Contact

RMND5A

Gene
RMND5A
Protein
E3 ubiquitin-protein transferase RMND5A
Organism
Homo sapiens
Length
391 amino acids
Function
Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). Catalytic activity of the complex is required for normal cell proliferation (PubMed:29911972). The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972).
Mass
43.993 kDa
Sequence
MDQCVTVERELEKVLHKFSGYGQLCERGLEELIDYTGGLKHEILQSHGQDAELSGTLSLVLTQCCKRIKDTVQKLASDHKDIHSSVSRVGKAIDKNFDSDISSVGIDGCWQADSQRLLNEVMVEHFFRQGMLDVAEELCQESGLSVDPSQKEPFVELNRILEALKVRVLRPALEWAVSNREMLIAQNSSLEFKLHRLYFISLLMGGTTNQREALQYAKNFQPFALNHQKDIQVLMGSLVYLRQGIENSPYVHLLDANQWADICDIFTRDACALLGLSVESPLSVSFSAGCVALPALINIKAVIEQRQCTGVWNQKDELPIEVDLGKKCWYHSIFACPILRQQTTDNNPPMKLVCGHIISRDALNKMFNGSKLKCPYCPMEQSPGDAKQIFF

Gene
Rmnd5a
Protein
E3 ubiquitin-protein ligase RMND5A
Organism
Mus musculus
Length
391 amino acids
Function
Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. Catalytic activity of the complex is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1.
Mass
43.993 kDa
Sequence
MDQCVTVERELEKVLHKFSGYGQLCERGLEELIDYTGGLKHEILQSHGQDAELSGTLSLVLTQCCKRIKDTVQKLASDHKDIHSSVSRVGKAIDKNFDSDISSVGIDGCWQADSQRLLNEVMVEHFFRQGMLDVAEELCQESGLSVDPSQKEPFVELNRILEALKVRVLRPALEWAVSNREMLIAQNSSLEFKLHRLYFISLLMGGTTNQREALQYAKNFQPFALNHQKDIQVLMGSLVYLRQGIENSPYVHLLDANQWADICDIFTRDACALLGLSVESPLSVSFSAGCVALPALINIKAVIEQRQCTGVWNQKDELPIEVDLGKKCWYHSIFACPILRQQTTDNNPPMKLVCGHIISRDALNKMFNGSKLKCPYCPMEQSPGDAKQIFF

Gene
rmnd5a
Protein
E3 ubiquitin-protein ligase RMND5A
Organism
Xenopus laevis
Length
391 amino acids
Function
E3 ubiquitin-protein ligase component of the CTLH complex.
Mass
43.952 kDa
Sequence
MDQCGTVERELEKVLHKFGGYGQLCERSLEELIDYAGGLRREILQAAEQDGELSGTLSLVLTQCCKRIKDTVQKLASDHKDIHSSVSRVGKAIDKNFDADISSVGIDGCWQTDSQRILSEVMVEHFFRQGMLDVAEELCQEASLSIDASQKEPFVELNRILEALKVRVLRPALEWAVSNREMLMAQNSSLEFKLHRLYFISLLMGGTVNQQEALQYAKNFQPFAENHQKDIQVLMGSLVYLRQGIENSPYVHLLDANQWADICDIFTRDACSLLGLSVESPLSVSFSAGCVALPALINIKAVIEQRQCSGVWNQKDELPIEVDLGKKCWYHSIFACPILRQQTTENNPPMKLVCGHIISRDALNKMFNGSKLKCPYCPMEQSPGDAKQIFF

Gene
rmnd5a
Protein
E3 ubiquitin-protein ligase RMND5A
Organism
Xenopus tropicalis
Length
391 amino acids
Function
E3 ubiquitin-protein ligase component of the CTLH complex.
Mass
43.975 kDa
Sequence
MDQCGTVERELEKVLHKFGGYGQHCERSLEELMEYAGGLRREILQAAEQDGELSGTLSLVLTQCCKRIKDTVQKLASDHKDIHSSVSRVGKAIDKNFDADISSVGIDGCWQNDSQQILSEVMVEHFFRQGMLDVAEELCQEAGLSIDASQKEPFVELNRILEALKVRVLRPALEWAVSNREMLMAQNSSLEFKLHRLYFISLLMGGTVNQREALQYAKNFQPFAENHQKDIQVLMGSLVYLRQGIENSPYVHLLDANQWADICDIFTRDACALLGLSVESPLSVSFSAGCVALPALINIKAVIEQRQCTGVWNQKDELPIEVDLGKKCWYHSIFACPILRQQTTDNNPPMKLVCGHIISRDALNKMFNGSKLKCPYCPMEQSPGDAKQIFF