Protein
Ribosomal lysine N-methyltransferase 4
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Function
S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates 60S ribosomal protein L42 (RPL42A and RPL42B) at 'Lys-55'.
Similarity
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.
Sequence
MDDFSRDTENFVCWLKTTAEIEVSPKIEIKDLCCDNQGRAVVATQKIKKDETLFKIPRSSVLSVTTSQLIKDYPSLKDKFLNETGSWEGLIICILYEMEVLQERSRWAPYFKVWNKPSDMNALIFWDDNELQLLKPSLVLERIGKKEAKEMHERIIKSIKQIGGEFSRVATSFEFDNFAYIASIILSYSFDLEMQDSSVNENEEEETSEEELENERYLKSMIPLADMLNADTSKCNANLTYDSNCLKMVALRDIEKNEQVYNIYGEHPNSELLRRYGYVEWDGSKYDFGEVLLENIVEALKETFETNTEFLDRCIDILRNNANIQEFLEGEEIVLDSYDCYNNGELLPQLILLVQILTILCQIPGLCKLDIKAMERQVERIVKKCLQLIEGARATTNCSATWKRCIMKRLADYPIKKCVSIEKPSKGNSLTREELRDVMARRVLKSEIDSLQVCEETIDKNYKVIPDEKLLTNILKRKLTEEEKSSVKRPCVKK