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RIX1

Gene
rix1
Protein
Pre-rRNA-processing protein rix1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
828 amino acids
Function
Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre-60S ribosomal subunits (PubMed:21385875). Regulates pre-60S association of the critical remodeling factor mdn1 (By similarity). Also required for heterochromatic gene silencing (PubMed:21385875).
Similarity
Belongs to the RIX1/PELP1 family.
Mass
91.996 kDa
Sequence
MSDLLERGSLPLVKSWLAITFANEEDLPFQVPQIADILVHQKCIERLGTSENALSVRKNWCTSLTKMLQSKDFRIRWSAIILIHCTISQSWDCLVEHGATWAKLLIALLNRPETPKTLEIAMITVSKMFSSTVGRPAVTRELVTPNLPTFVNNCLRIAESGKCLCTVCSCLYQGIISHSPTFRPFVSSIRNICIKILDGEEVVPSSLQKKAAVLYASLYRCVGKGNFEDYWKQSIISILKEYHLTLDFLFQFVIEPQTYPTREENLMFPKLKGHYEETYQKALHRCRTLNLILISFLSTKTDKIVLLPINALKDLIQRVYTVQLSLPVKSVESSVQALLFMVLPHLHTLVNELTLKLFVVIPPAIILSFDSYLDSLNDCLLSESTHTGVLCSSLKLLSKFLDVTHMNVPLSKYENIVTLVLEYLANSSKGLASKSIEFSKNRGHSQKKRKTLSESQAGDTLMSSEESHQLYDSDVMDCCFSFLASILTHSIALPRLLRTKIDLCTLQISLSNPTSTVLISMHNLLLASILSPGDSQAVIVPHAIRIISGPLGLVHPDPLVASHARSSMQTIESLIHPRFPPLQKHLSPSEFENTFESRFEPVSLENQSHISPPQVDSQSEYKESSILAPSNPPFETESITDSTEIEGIKESFASTDTGLQNNSTATSENKRSESELTMSNVLSNEGDRNEEGSEINSSQPSTINHGTDHINIVSENKETTVSLLHGDVEVEETTNVALNNSQDTETKFTAIDVDFVDRPTSVVSSQIENINGDENGNTTSSVVETFEKTTDVVDEKTTSINVEGNGEDDEEEDNISLPSINLESDSDS

Gene
RIX1
Protein
Pre-rRNA-processing protein RIX1
Organism
Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)
Length
793 amino acids
Function
Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre-60S ribosomal subunits. Regulates pre-60S association of the critical remodeling factor MDN1.
Similarity
Belongs to the RIX1/PELP1 family.
Mass
88.981 kDa
Sequence
MSIINIVLEGISENHSSQSIVPVLELLRNDKTILSNISKLQLQQLVSRSLQLVRSSDSYSKWCGINLIHQLSSNYVIVAQSGVQFMSALIAVLESYNSTINVLILRNCIECLQVLMHEIRGKPALTREILTPKLSTIITLVMGHIQFDAETCLNLLYDVILHHPNTFRPFANKLRSKLLVFLKGGFGVEFVEMPTSLRKIICQTMAILPIIEKNEPEAKWGNDVKNVISEVTGILNVFDEFFNFRDDSSLGKLISKLPGRGERAELGEGDRERVFDDLSIDFNEPRSLLAISDQVETLLQLLKHYLVGGGITSVRLPLGLCLTLLEVVFSINARFLSYKSDVRDDEIRQLISTVLNRVHTSGIELLSSLLQFRGALVPHLNQIWTMLEYLVPMIQNKRIDAAEVVKNEAVFAKLVECVGLYLNLVGAVSDGASLVPFVDVALTLVEPRKDSAGNMQQSAADGQQKNQNKNKNQKNKIKKKNASSAPMSDILSHEHLFQQTIPTQTLLAVQYFFSQVITKVELPSNQHYKTLRFIIRQCVEHKNSNLEQAVPKQLRDLLVNTVLYPGYDKNNALPIVSSILIDDPIISVFNNPRLPALPKYHSMSTSMDNKDVTEVGLEQTTYQRNRNGDDDHDDDDDDDDDDDEEVSASKGSGKKLSAKELAIQNLMREQAERQKLDREKEANARIEKDAEHEATPSFAFQMEKRPREEIVEEVGKVEKKIKVGEHGLVKDTVLKSTVETVVDNKNDVANVSKNDQAQDAVGADEDNEGSDFEIPEINMELDTDEEEEGEEAE

Gene
RIX1
Protein
Pre-rRNA-processing protein RIX1
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
776 amino acids
Function
Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre-60S ribosomal subunits. Regulates pre-60S association of the critical remodeling factor MDN1.
Similarity
Belongs to the RIX1/PELP1 family.
Mass
87.936 kDa
Sequence
MATVTVPLSSLAKLIEESEGSQFRSILQTLRSPTYVNQSLLKSDIGVFVAKLLKLLRSSEPYQIWKGCHAVAVLCSNNPVVLCSQANQFLTVLYTRLESFINFYVETSQSAARLTTLKTLTRTVDILMDLIRGKPTLTREALTPKLNAVIPLLMTLCQYEPELCLPILKKLLLQNTTTFKPFANKYRVILNRLITKDFQLYDRTTQRLICDNFAYLHLIKQNAQKLEENQEHHKTLMDENWRSSILSVLYQFKPLILLCGDILDFSVDSEMLNFIDSLPTPKKDTGEIKDELFAPLSVDMNESFSLWEISYRVEVLSQLLISFISLPTSFPLRIPLHGIIDICQALLMLSTNYLPLKRGLRRETELTAVIITVLRSLQYQGIVVLKSISRCYGKDILYYYSSILSSLELFIPIKARGNAIDYEKVESMKEQVFDLLSLINTLAGHLGHKIDELDLFTKLTDITLRLVEEKSNLGKFYTTVNDAKSIKQTTKQKKDYNKMAGAMSDIYSHPKQFVNKTELRWYDEANKFLSLVVQNWKLPSTQQVNIIKYATVMSITLNEQIGNIPESFEELLTTIVLYPGSERLSILPIAVGLLKNMDNKVFDVLCNPRLPFSCLLNPGSSSIRKDIRNALKMPNGDSDETEETIVTGQQDVLDQSDANGIVTANDIERDRDGPENSIEKPLSALTSIVSDESQIFRKRAVEESESEEEETKRQRPDSAEETENNGETVVIPNVPTQVLQTVETTETAQQPDSDSDSEIEIPTINVSDNDDDDDEE

Gene
RIX1
Protein
Pre-rRNA-processing protein RIX1
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
769 amino acids
Function
Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre-60S ribosomal subunits. Regulates pre-60S association of the critical remodeling factor MDN1.
Similarity
Belongs to the RIX1/PELP1 family.
Mass
87.628 kDa
Sequence
MSINIVLEEIKGTPSSIIPLLSILHNDKQILSTITKTELNHLISRTLNLVRSSDVYNKWCGINLIRVIVEEYSILASEGNNLMNSLLQVLEAYQQQQHHHHHQTTIDLKILTSCIETINYMGDLIRGKPTLTREILTPKLNSIIGYYFQYLHFAPLLILNSLQTLLKFHPTTFRPFGNKLKTKLINLIDGGGGEEFINYPQDLQLSIYNTLAMLPIIEKIEPETKWYNDVINILGEINGLIQIYQEFLNFKDDQDLSNLIQKLPNRPTTTTTTTKLLTDLSIDFNKPQTILSISNHLNILMGVLKSYLTVETLFTVKLPLGLILTTCELICSINTKFLSFKGDIRDETIKKLIKFSLIENYKTTLGVLIELIELYKGSLIPHLTTIWSFLETLIPFQNQNKRIVNEEIIESESLYVEILQFMKQSLSLLGNVSENTQLLRFVDMALILVEPRINPTTTTTTTNNNNNNNNTKQTNVQQGKKQKKRKNTSSVALSDILSHEHLFMTNIPTITITTVRSFINQIITKIILPPTQHYKIMRYLIIESIHAKYYNLYHNVPIELKKLLINAVLYPGYDKISILPIISTILSDDPLLGVFNNPKFPPLPKYINLVNNIEEEEQKEEQEEDAIIEDEVEEPIKEELTTPLKKRKLDIESNEETDNNNIIPVEDQSKIFTATKVEKLTTTTTSSIENNPVVIEELTSSKEIVVESPVDEPTKVDNIIPTTTTTTTTTTSLTSNTANANDDNDNDDDDESSDFEMPEINLDQDSDDE

Gene
RIX1
Protein
Pre-rRNA-processing protein RIX1
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
767 amino acids
Function
Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre-60S ribosomal subunits. Regulates pre-60S association of the critical remodeling factor MDN1.
Similarity
Belongs to the RIX1/PELP1 family.
Mass
87.354 kDa
Sequence
MNKAIPVSVLADQLAESNGFQFHNILYHLKSSDYVDEKLLKSELSVLVVKIQKLLNSNSNYSIWKGCHAAVVICTYNPLVLMAYGGKLLDIVYQKLEIKVLQRSTNSLDAQGKQVLNSLVNAISVLMNLMRNKTGLSREFLVPKIKAIIPTLITLSQYEPELVLPILRSLIFKHTTTFKPFNAKFKVILTQFLTEGFDTLNEHTQKLVCDCYAYLHMVKTQTYQQQDEHSSHHKTFQDENWMNGMNAVLAEFKPLIELCGEILDFSQDEELTKLIGKMVPLAAESTSIFRSLTMDMNKSTTLYDIPKRIDVLSKMLMSFISVPTTYTIRIPLDKLNVTCSALLSITSKHIPIKRELRRDIELNATINDVFTKIQFAGIRLYSTMVSKFGNVCFSYLSDIFYALSLFIPFKEKSLNIDFEKCFALKREFLVVFDLVSKIIANVGHQLTDIDFLLQLIEIGLDLTEERSLIQNVFQQTNAKKEQELSKTKNKNKKDNKRGSLADLYVSGSQFTLACDLKTFDTLNKFFISIIANQKLATAQMTKLSRYAIFTAQTYKQNLGEVPTTFVELLRTLVIQPGNERVTILPMAVNIIKESSDDVFDILSHPRLPMSILHSIEKSTFDNGEDDEDDNPDLHANEKQQEYNDQPVERSEQKVVDFVLEEPVAVDVKTKETVQFKDGITTSEDQVDTKRPRDEEFIIEKSSSAKKFRTENQPETIPIGVSDETVYQETEKVTVNVDTSSNDNEDDEDDSDFEIPAIELSDDDDEDE

Gene
RIX1
Protein
Pre-rRNA-processing protein RIX1
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
764 amino acids
Function
Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre-60S ribosomal subunits. Regulates pre-60S association of the critical remodeling factor MDN1.
Similarity
Belongs to the RIX1/PELP1 family.
Mass
85.366 kDa
Sequence
MTSQVVPLSTFVQHLESCEGYEFRTMIKMLASPAYAKQQLLKDELSVFMAKVLKLLRSKDDYQVWKGCHIATVFCTYNPVVLCSFGGELMGILYRALEDATKYYGDSVQTEQRKVMVRALVKTLDTLMDLIRGKPSLTREALTPHLSAIIPMLISFGRCEPNLSLPVIKKLLSKHSTTFRPHVGKLKQLLTELYGHYQSLDPVTRKVVCDTAAYLHLTQKPGNNANEHQAHHKSFPDEHWRAGLFSVLSQFGPVVRLWGEILDIGSDENLARLLETLPRDTANDTSPLLPALTVDINKPVTLWHISARLEQLTDMVESFIRLPTLFPTRIPLGELVKVSEILLSLTTNYLPLKRGLRRDAALTGSIRSALPETQLQGIRLLRCLSDHIGKNLITYMPAILSSMELFIPLKDKKTSIDYQKCVDLQNGLLQLTALMNSIAQHLGHKVEEMSLAIKLVDICAYIIEHKQNLDSAFSSTSGTAKAAGGAKKKEYKAKTGSMSDLFSHPHKFLHPVPLENYTVVNTYYNMALTHWKLPSTQQAKITKYCIYYSLSFKEKLGYIPQTFIELLNTIVLFPGKDRFSILPIAVHLLKETGDPVFDVLCNPKLPLEMIQIRRQPTSSEDDTATSEAEEYAAPADQDDEHLSDDEHTTVDDGVATNAVMGLNNLVSSETLRSEQDSALETQHPEQARTSNLVPDEASEGREDARIFKKRSSSDEQDPPSKRTRAVAAQTPVPAAVPVDNGEPESDDGSDFEIPEIELSDADEE

Gene
RIX1
Protein
Pre-rRNA-processing protein RIX1
Organism
Saccharomyces cerevisiae (strain YJM789)
Length
763 amino acids
Function
Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre-60S ribosomal subunits. Regulates pre-60S association of the critical remodeling factor MDN1.
Similarity
Belongs to the RIX1/PELP1 family.
Mass
86.797 kDa
Sequence
MSEEFIAVSTLARNLEIAKGNEFHTILATLRSPVYINEQLLKSELSFLVTKILKLIRSGNDFDLWKGCHTSVVTCAYNPLVLSTHGGQLLAAIYSRLEQKTGFYSSVISSSHGKQLFNILISSVAIIIDLMKNKPTLSREALVPKLKAIIPTLITLSQYEPELVLPVLQRILKRNTTTFKPFTNKFRTVLINLIISDYASLGTKTQRLVCENFAYLHLLKIQVSDTSDDETQAHHKIYADSNWRTGLMSILSQFKPIIQLCGEILDFEQDNELYKLIKSLPVIDESNNKEEFLPSLKLDFNAPLTLWEIPQRLSLLADMLVAFISLPTPFPIRVPLGGINSLCEVLLGVSNKYLPLKKELRRDNELNGVINTILPQIQFQGIRLWEIMVSKYGKCGLSFFEGILSSIELFIPLKKKSNNEIDFNVVGSLKFEFATVFRLVNMILSHLGHQLNIISVISQLIEVALFLSHDKTLIDSLFKNRKSIMKQQTKTKQSKRSKSAEGAFSDIYTHPELFVCKNSMNWFNEINDFFITALNNWILPSTPHIQILKYSITQSLRLKERFGYIPESFVNLLRCEVLHPGSERVSILPIAISLLKNINDDMFELLCHPKVPVGMVYQLHKPLDLGEDGEVRDDINKKEVETNESSSNANTGLETLKALENLENVTIPEPKHEVPKVVDDTAIFKKRSVEEVIERESTSSHKKVKFVEETTVDNGEELIVKKAVNQTKEEEKPMEDSEDEEQEEFEIPAIELSDDEEEEEEEE

Gene
RIX1
Protein
Pre-rRNA-processing protein RIX1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
763 amino acids
Function
Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre-60S ribosomal subunits (PubMed:11313466, PubMed:14759368, PubMed:15528184, PubMed:26619264). Regulates pre-60S association of the critical remodeling factor MDN1 (PubMed:26619264).
Similarity
Belongs to the RIX1/PELP1 family.
Mass
86.739 kDa
Sequence
MSEEFIAVSTLARNLEIAKGNEFHTILATLRSPVYINEQLLKSELSFLVTKILKLIRSGNDFDLWKGCHTSVVTCAYNPLVLSTHGGQLLAAIYSRLEQKTGFYSSVISSSHGKQLFNTLISSVAIIIDLMKNKPTLSREALVPKLKAIIPTLITLSQYEPELVLPVLQRILKRNTTTFKPFTNKFRTVLINLIISDYASLGTKTQRLVCENFAYLHLLKIQVSDTSDDETQAHHKIYADSNWRTGLMSILSQFKPIIQLCGEILDFEQDNELYKLIKSLPVIDESNNKEEFLPSLKLDFNAPLTLWEIPQRLSLLADMLVAFISLPTPFPIRVPLGGINSLCEVLLGVSNKYLPLKKELRHDNELNGVINTILPQIQFQGIRLWEIMVSKYGKCGLSFFEGILSSIELFIPLKKKSNNEIDFNVVGSLKFEFATVFRLVNMILSHLGHQLNIISVISQLIEVALFLSHDKTLIDSLFKNRKSIMKQQTKTKQSKRSKSAEGAFSDIYTHPELFVCKNSMNWFNEINDFFITALNNWILPSTPHIQILKYSITQSLRLKERFGYIPESFVNLLRCEVLHPGSERVSILPIAISLLKNINDDMFELLCHPKVPVGMVYQLHKPLDLGEDGEVRDDINKKEVETNESSSNANTGLETLKALENLENVTIPEPKHEVPKVVDDTAIFKKRSVEEVIERESTSSHKKVKFVEETTVDNGEELIVKKAVSQTKEEEKPMEDSEDEEQEEFEIPAIELSDDEEEEEEEE

Gene
RIX1
Protein
Pre-rRNA-processing protein RIX1
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
751 amino acids
Function
Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre-60S ribosomal subunits. Regulates pre-60S association of the critical remodeling factor MDN1.
Similarity
Belongs to the RIX1/PELP1 family.
Mass
84.823 kDa
Sequence
MSLPLDVILEDLESSPKSIIPILATLHRDKAFLNDISKTDLKHLVSRSLNLSKSHIAYNKWCGINLIKVLSNNYNILANEGVNFMSQLIKILENYNQSIDPKILSSTVECLNNLCNQIRGKPTLTREVLTPKLPTIITLFMEKVAYQPSLILRSLNSLIRKHPTTFRPYGNKLRNRLIELLSSESYSAFPQELKQIICETLATLPIIEKTEPEAKWQGDIVDIVKELSQVLLIYDEFLSLNDDSDLMELFKKIPRTRESEESESSFKFASLEIDINKPDTIFQISDRVELLLSIMKAYLLSETQFSVRVPVGLVLIINEIICSISTKFVPFRKDIRDEKVKKLIKSTTLLNQFNSIKLLSELPIKYQGSLVPHLNNILAFLEILIPFSNKKIDYQEVLSNEIFMCRLLECTGNFISLVSSLSDASLLIRFIDVALCLVEERALNTSPVSDGKKQNQQANGNKKKNKKKNKESVPLSDLLSHQHLFNETIPLSTLNATRRFLNMVITRVNLPPTQHYRVFRYMIIEATVAKSYNKDQNISQELKQLLINSVLYPGFEKNSMLPIITSLLGDDPLLSVFNNPRFPPLPTYIKKSGSVIEDDEEEEESENEDEEMEENENDGSLNVDEESQLESSAKRRKIDISESSAGGGSDQPETVLPGIVLEDTKTKEKIFTNVNPDSVIQFAETSEIVEDVVPEPEATRTEVVTKSSVGTIPTPENPVATSVSVSVDKNEHDESDFEIPDIDVGDDSDDE

Gene
RIX1
Protein
Pre-rRNA-processing protein RIX1
Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)
Length
724 amino acids
Function
Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre-60S ribosomal subunits. Regulates pre-60S association of the critical remodeling factor MDN1.
Similarity
Belongs to the RIX1/PELP1 family.
Mass
82.686 kDa
Sequence
MSIPLSLVLKQLEGSPSSVVPLLSTLYYDKSILNNISKSDSKHLVSRILNLTRSPIEYNKWAGTNLIRVISDNYTILATEGSNLFGELVKNLDSYNDTVNIKVLTSTVEALNYLCDKIRGKPTMTREILTPKLSTIITLYMDKLHFSPLIIIKSLKKLIQFHPTTFRPFGNKLRAKLITFLHLQDFVNFPEPLKSAIYQTLASLPAIEKTEPELKWESDVKSLIKELKSVLAIYNEFLNLGDDSSLPRLFEQLPSFEENQKNDKILPDMVIDVNEPSSVFQISTRVDILLNLLNAYVTYATQFSVKVPLGLVLVVNEIICSINVRYISYKNDVRDEQIRKIVKSTTVLNSLNSIKFLKDLAFTYKGSMLPHLGNILSLLEVLVPFKNKKIDYDELIIQEVLNRELLSCVSVYLSLVSFLSDHTQLLRFVDVGLLLVEPRITDSTAQQNNNNHNSNGGKKHKKNKNTTAIPLSDILSHQHLFNEAIPEATVNIVRQFMSAVITTVTLPPTQHYKIMRYILIQAVHSRYYNNEHLIPRELRSLLINAVLYPGYEKISLLPIVSTILGDDPLLSVFNNPRFPPLPIYVKNVKDESVFEEEEEEEEEHEQEEKEIELPEQKRAIDEDELPEAKKRKMEDEPQVIQQEQIEQVVEDKIFTKVNPETVVHFAPTKEVEPESRTIQNQKPETVPEPVPVAPVQQMSQNINGDEDESDFEMPEIDVDDSDEE

Gene
RIX1
Protein
Pre-rRNA-processing protein RIX1
Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)
Length
712 amino acids
Function
Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre-60S ribosomal subunits. Regulates pre-60S association of the critical remodeling factor MDN1.
Similarity
Belongs to the RIX1/PELP1 family.
Mass
79.4 kDa
Sequence
MLPLAVILSELQEPKTIVPVLSSLRSGSPVWSNISGPDQKHLVSRTLNLTRSSIQFRRWFGINVIRVLADNYKIMAGDGSQIIGQLLKLLEQCNQFTSAVYFKSLVECIDHVCDSIRGKPTMTRELLTPNLPAIIGLYLEKFSHDPAYLVSRLAPYIRAHPTTFRPFGNKLRSKIMETILSPAFSNFPDSSKDIFCNTLSTLCAVEKIEPEERWSSDLFSLIGELSNTLEIYGEFLNFEDDAELGKLLKKIPRSSSGESEFPSLSIDINDPSSFYSLPERLDILLRLIRGYLSAPTSFVAKVPLGIIALVVEAVLSINSRFIPFKREIRDESTKQIIRNTLQCAHSSALGLLKVLPSIFRGSLVPYMRRILGLLETLIPMKKKSLDTDQIVANEQFICLVLDCVACNISLVSYYQDSTGLVRLIDAAMAIVQPRSSSNTSSNTANTISSNGKKKKKQASVPLADVLSHQHLFNISVSESTTNHVQSFVNTLISCADLPSAQHNKVCKFVIVEAVKASHHIQEGTVPKQLRNLLVNAVLHPGFETTSILPIVCSILKEDELLSVFRNPRFPPVLKAVEVKEEEEEEEEEEESEEEPEEAEEAEEVVNGSRTEREVAPETKEVEPENKRRKIEIPEAVSVEPQVSEPQISTSLQHSISNQPEPAEPKNLRAPEPVKQANNPKLTEPSAAKDLREDFSDDSDFEMPEIDVDSDDE