Ripor2

Rho family-interacting cell polarization regulator 2

1310 amino acids

Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization. Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation (By similarity). Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration (By similarity). Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion. Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear. Plays a role for maintaining the structural organization of the basal domain of stereocilia. Involved in mechanosensory hair cell function. Required for normal hearing (By similarity).

Belongs to the RIPOR family.

144.709 kDa

MQHCLEQSDITQYQQYYSSWCDARALGPRLSPVALSLLVGRNEHRLSAEPEVHRSQGRCVGVEVPREDINYLSTTCKPEIKSRNLKEDSEDQGRLPTRLPEIMLVGSQSFSPGGPNGIIRSQSFAGFSGLQERRSRQVLGVSPGITRAPSKDVYCKPGYACRVEFLLCKAFSKQTCNSFIENASALKKPQAKLKKMHNLGHKNTNTPKEPQPKRVEEVYRALKNGLDEYLEFHQTELDKLTAQLKDMKRNSRLGVLYDLDKGVLYDLDKVDELYEAYCIQRRLQDGASKMKQAFATSPASKAARESLSEINRSYKEYTENMCTIEAELESLLGEFSIKMKGLAGFARLCPGDQYESMDGPNPYQRQQGEVYFSLLATRRIGDGSCLSKGARIFMKYGRQRWKLKGKIEVNGKQSWDGEETVFLPLIVGFISIKVTELKGLATHILVGSVTCETKELFAARPQVVAVDINDLGTIKLNLEITWYPFDVEDTTPSSGPGNKTAALQRRMSMYSQGTPETPTFKDQSFFSNLPDDIFESGNAAEEKRPLSLSFSDLQDGDCVFTSSSTTSPSSSHSAHPEITITPAELTHSSLSSQNEGTEDSSSASSRNSLGEDHEPKSHSKSDTVEPKKPSVDARSGTESLFLENSVAEALLQESDEASELKPVELDTFEGNITKQLVKRLTSAEGPITTNKLFFEGSVGSESEAGRSFLDGSLEDAFNGLFLALDPHKEQYKEFQDLNQEVTHLDDVLKCKPAGSRSRSSSLSLTVESALESFDFLNTSDFDEEEEDGDEVCHVGGGADSVFSDTETEKSGSVHPEARGHLSEALTEDTGVGTSVAGSPLPLTTGNESLDITIVKHLQYCTQLVQQIVFSSKTPFVARSLLEKLSRQVLVLQKLAAVSDENLGNITSVVEAIPEFHKKPSLLSFWTKCCSPSGVYHSSAAHLIKQLEASFARNINKDYPGLAEPVFRTLVSQILDRAEPLLCSGLSSEVITVFQYYSFLTSHGVSDLETHLGQLARQVAMVQTLQSLRDEKLLQTMSDLAPSNLPAQQEVLRTLALLLTKDDNEVSEAVTLYLAAASKNEHFREKALLYYCEALTKTNLQLQKAACLALKSLEATESIKMLVTLCQSDTEEIRTVASETLLSLAPYSGSAMTSQIRQNYSTEVEAAVNRLVNLHLRASYTYLSLGFFFDPDDVALEGNERGGRALFQDVQKPSQDEWGKTLEAMEAALALEKNLNQALLDLHALGSARTDPHLCDFLESHFLDKEVKLIKKMGNHLTNLRRVAGPQPAQTGVAQASLGEYLFERLTLKHD

ripor2

Rho family-interacting cell polarization regulator 2

1083 amino acids

Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization (By similarity). Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation (PubMed:24958875). Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration. Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion. Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear. Plays a role for maintaining the structural organization of the basal domain of stereocilia. Involved in mechanosensory hair cell function (By similarity). Required for normal hearing (PubMed:24958875).

Belongs to the RIPOR family.

120.498 kDa

MAFPDITEDDLNELMREEAEDVFDDDGVSSRFPDIMAAGTHSPGGPNGIIRSQSFAGFSTLQERRSRCNSFMGNSAVQKKPISKPRKPHLSGHKSSSSSSSSREPQPKRVEEVYSALKQGLDEYLEVHQTELDKLTSLMKDMKRNSRLGVLYDLDKQIKTIERYMRRLEFHISKVDELYEGFCIQRRLRDGASKMKQAFTASPSTKGTRESLAEVNRRYKEYTENMSTFEGELENLLGEFHIKMKGLAGFARLCPGDQYEIFMRYGRQRWKLKGKIEGNSKQSWDGEEMIFMPLISDLINIKVTELKGLATHVLVGSVICETKDLFTAMPQVVAVDVNDLGTIKLNLEVAWFPFDVEDLTLSSGNVSKATALQRRVSVYSQGTPETPTFQDTSFFKWQPRRWEGQRLSFLHTLRETLIEKLRRSRSFGDLAALRPRSRSSLEVYSTLPDDVFENGGCGVAECKRLSFTFSDTSTSSPVPVQSNPEITVTPPETDPSSEPPPTSEEQLVEEECVEEDCGSISVSVSVSDPDLEWDQVETQGPETGSVALSLCSESQLSAVGPEDVVFLEPNVSDEALELKPVELDGEEGSLTRQLVRRLTSSDMLPETSALSWAGENSRTFMESSLEEVIQSLLLRLESLGQRCGELQDLEQEVMRLEDLLKCRVHAHRSRSSSLSLTVESALESFDFLNTSDFDDDDTGDDAGTLSRAVFFDMESERMGSGQHPEARGHLSEALTEDTGVGNSVAGSPLPLTTGNENLDVAVVIHLQYCNHLIQLLTSGGSQLQHKTYLHKLATQTLLLEELSERNFDRPSSCTSVPDVLPGLVERPALMSLWSDCSGGLFHTTLDRVLKHMHLSFALGLQQVLPHSPDSVIKMVVNEMMDRSELASSSTSPAQDVITVFQFHRYIVEHCITDMEQHLLDLAKEVMLEEALSCGDPERSLKELKKVSITCLQPRSQTLLAVAGLLTTDDPEVMKATTDFLSSAASHQPFRSKAVDCYTQALSESELHTQRAACAALSCLQAVESIDAVILLCDSVDEELRQIAIETLLTFGEDGRLAYEQLDTVPREMVRLGTRRGNAVTTSF

Ripor2

Rho family-interacting cell polarization regulator 2

1078 amino acids

Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization (PubMed:25588844, PubMed:27269051). Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation (PubMed:17150207). Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration (By similarity). Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion (PubMed:25588844). Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear (PubMed:27269051). Plays a role for maintaining the structural organization of the basal domain of stereocilia (PubMed:27269051). Involved in mechanosensory hair cell function (PubMed:27269051). Required for normal hearing (PubMed:27269051).

Belongs to the RIPOR family.

118.97 kDa

MPPGTKRLRALGAFSAGLPTRLPEIMLVGSQSFSPGGPNGIIRSQSFAGFSGLQERRSRCNSFIENASALKKPQAKLKKMHNLGHKNNNTPKEPQPKRVEEVYRALKNGLDEYLEFHQTELDKLTAQLKDMKRNSRLGVLYDLDKQIKTIERYMRRLEFHISKVDELYEAYCIQRRLQDGASKMKQAFATSPASKAARESLSEINRSYKEYTENMCAIEAELESLLGEFSIKMKGLAGFARLCPGDQYEIFMKYGRQRWKLKGKIEVNGKQSWDGAETVFLPLIVGFISIKVTELKGLATHILVGSVTCETKELFAARPQVVAVDINDLGTIKLNLEITWYPFDVEDTTPSSGPGNKTAALQRRMSMYSQGTPETPTFKDQSFFRWLRLSVLSALRDTFFATLHHNHSVGDLPSLSLNPKALLEFYSNLPDDIFESGKAAEEKRPLSLSFSDLQDGDCVFTSSSATSPSSSHSAHPEITITPAELTHSSLSSQNEGTEDSSSASSRNSLGEDHEPKSHPKSDTVEPGKPGVATRSGTESLFLESSVAEALLQESDEASELKPVELDTFEGNITKQLVKRLTSAEGPVTTDKLFFEGSVGSESEAGRSFLDGSLEDAFNGLFLALDPHKKQYKEFQDLNQEVTHLDDVLKCKPAGSRSRSSSLSLTVESALESFDFLNTSDFDEEEEDGDDVCHVGGGADSVFSDTETEKSGYRSVHPEARGHLSEALTEDTGVGTSVAGSPLPLTTGNESLDITIVKHLQYCTQLIQQIVFSSKTPFVARSLLEKLSRQVLVMQKLAAVSDENLGNITSVVEAIPEFHKKLSLLAFWTKCCSPSGVYHSSAARLIKQLEASFARSINKDYPGLAEPVFRTLVSQILDRAEPLLSSSLSSEVITVFQYYSFFTSHGVSDLETYLGQLTRQVAMVQTLQSLRDEKLLQTMSDLAPSNLPAQQEVLRTLALLLTRDDNEVSEAVTLYLAAASKNEHFREKALLYYCEALTKANLQLQKAACLALKSLEATESIKMLVTLCQSDTEEIRTVASETLLSLGEDGRLAYEQLDKFPRDCVKVGGRHGTEVATAF

RIPOR2

Rho family-interacting cell polarization regulator 2

1072 amino acids

Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization. Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation (PubMed:17825087). Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration. Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion. Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear. Plays a role for maintaining the structural organization of the basal domain of stereocilia. Involved in mechanosensory hair cell function. Required for normal hearing (By similarity).

Belongs to the RIPOR family.

119.322 kDa

MSIGSHSFSPGGPNGIIRSQSFAGFSGLQERRSRCNSFIENTSALKKPQAKVKKMHNLGHKNSTTPKEPQPKRVEEVYRALKNGLDEYLEVHQTELDKLTAQLKDMRRNSRLGVLYDLDKQIKAVERYMRRLEFHISKVDELYEAYCIQRRLCDGASKMKQAFAMSPTSKAARESLTEINRSYKEYTENMCTIEAELENLLGEFCIKMKGLAGFARLCPGDQYEIFMRYGRQRWKLKGKIEVNGKQSWDGEEMVFLPLIVGLISIKVTEVKGLATHILVGSVTCETKDLFAARPQVVAVDINDLGTIKLNLEITWYPFDVEDLTPSTGNVSKASALQRRMSMYSQGTPETPTFKDHSFFRWLHPLQDRPRLAILDALQDTFFDKLRRSRSFSDLPSLRLSPKAGLELYSNLPDDVFENGTATTEKRPLSFTFGDLPYEDRVPPANSAEPSSAHVTSSPDIATTATQHRARAQTAAAVTPAEGKACPGVRCEPRGHGDSCQEYPPGFQKPSDTGSDRVFIEANVPVSLLQDTDEGSELKPVELDTYEGNITKQLVKRLTSAEVPGTPERLPCEGSISGESEGYKSYLDGSIEEALQGLLLALEPHKEQYKEFQDLDQEVMHLDDILKCKPAVSRSRSSSLSLTVESALESFDFLNTSDFDDEDGGGEEVCNGGGGADSVFSDTEVEKNSYRTEHPEARGHLQRSLTEDTGVGTSVAGSPLPLTTGSDSLDITIVKHLQYCTQLIQQIVFSRKTPFVTRDLLDKLSRQTLVMENIAEISTENLGSITSLTDAIPEFHKKLSLLAFWMKCTGPSGVYHTSADKMMKQLDINFAATVNEECPGLAETVFRILVSQILDRTEPVLYSTMSSEIITVFQYYNYFASHSVNDLGSYLLQLAKEASVVQMLQSVKDGKLQQNVSKINSNNLPPQQEVLRALALLLNENKNEVSETVASLLTATAENKHFREKALIYYCEALTQPNLQLQKAACLALRYLKATESIKMLVMLCQSDNEEIRKVASETLLSLGEDGRLAYEQLDNSPGNLSELEVAGELNLPQLSRRTCLSVTATEEGWSCH

RIPOR2

Rho family-interacting cell polarization regulator 2

1068 amino acids

Isoform 2: Acts as an inhibitor of the small GTPase RHOA (PubMed:25588844). Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation (PubMed:17150207). Maintains naive T lymphocytes in a quiescent state (PubMed:27556504).

Belongs to the RIPOR family.

118.519 kDa

MLVGSQSFSPGGPNGIIRSQSFAGFSGLQERRSRCNSFIENSSALKKPQAKLKKMHNLGHKNNNPPKEPQPKRVEEVYRALKNGLDEYLEVHQTELDKLTAQLKDMKRNSRLGVLYDLDKQIKTIERYMRRLEFHISKVDELYEAYCIQRRLQDGASKMKQAFATSPASKAARESLTEINRSFKEYTENMCTIEVELENLLGEFSIKMKGLAGFARLCPGDQYEIFMKYGRQRWKLKGKIEVNGKQSWDGEETVFLPLIVGFISIKVTELKGLATHILVGSVTCETKELFAARPQVVAVDINDLGTIKLNLEITWYPFDVEDMTASSGAGNKAAALQRRMSMYSQGTPETPTFKDHSFFRWLHPSPDKPRRLSVLSALQDTFFAKLHRSRSFSDLPSLRPSPKAVLELYSNLPDDIFENGKAAEEKMPLSLSFSDLPNGDCALTSHSTGSPSNSTNPEITITPAEFNLSSLASQNEGMDDTSSASSRNSLGEGQEPKSHLKEEDPEEPRKPASAPSEACRRQSSGAGAEHLFLENDVAEALLQESEEASELKPVELDTSEGNITKQLVKRLTSAEVPMATDRLLSEGSVGGESEGCRSFLDGSLEDAFNGLLLALEPHKEQYKEFQDLNQEVMNLDDILKCKPAVSRSRSSSLSLTVESALESFDFLNTSDFDEEEDGDEVCNVGGGADSVFSDTETEKHSYRSVHPEARGHLSEALTEDTGVGTSVAGSPLPLTTGNESLDITIVRHLQYCTQLVQQIVFSSKTPFVARSLLEKLSRQIQVMEKLAAVSDENIGNISSVVEAIPEFHKKLSLLSFWTKCCSPVGVYHSPADRVMKQLEASFARTVNKEYPGLADPVFRTLVSQILDRAEPLLSSSLSSEVVTVFQYYSYFTSHGVSDLESYLSQLARQVSMVQTLQSLRDEKLLQTMSDLAPSNLLAQQEVLRTLALLLTREDNEVSEAVTLYLAAASKNQHFREKALLYYCEALTKTNLQLQKAACLALKILEATESIKMLVTLCQSDTEEIRNVASETLLSLGEDGRLAYEQLDKFPRDCVKVGGRHGTEVATAF

RIPOR2

Rho family-interacting cell polarization regulator 2

1016 amino acids

Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization. Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation. Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration. Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion. Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear. Plays a role for maintaining the structural organization of the basal domain of stereocilia. Involved in mechanosensory hair cell function. Required for normal hearing.

Belongs to the RIPOR family.

111.934 kDa

MLVGSQSFSPGGPNGIIRSQSFAGFSGLQERRSRCNSFIENSSAVKKPQAKLKKMHNLGHKNSSPPKEPQPKRVEEVYRALKNGLDEYLEVHQTELDKLTTQLKDMRRNSRLGVLYDLDKQIKTIERYMRRLEFHISKVDELYEAYCIQRRLQDGASKMKQAFATSPASKAARESLAEINRSYKEYTENMCAIEAELEKQLGEFSIKMKGLAGFARLCPGDQYEIFMKYGRQRWKLKGRIEVNGKQSWDGEEMVFLPLIVGFISIKVTELKGLATHLLVGSVTCETKELFAARPQVVAVDINDLGTIKLNLEITWYPFDVEDMTPSSGAGNKVAALQRRMSMYSQGTPETPTFKDHSFFSNLPDDIFENGKAAEEKMPLSLSFSDLPNGDCTLAPGPADSLPGACAANPEITITSTELPPGSQSSQNEGLKDSSSASCSSSSREGSEPRPHPEGETQGLGKPEGCPVATGARPERLFLQKGVAEALLQEALLQEPSELKPVELDTFEGNITKQLVKRLTSAEVPAATERLLSEGSISAESEGCRSFLDGSLEDAFNGLFLALEPHKEQYKEFQDLNQEVMHLDDILKCKPAVSRSRSSSLSLTVESALESFDFLNTSDFDEEEDGDEVCNVGGGADSVFSDTETEKNSYRSVHPEARGHLSEALTEDTGVGTSVAGSPLPLTTGNESLDLTIIRHLQYCTQLVQQIVLSSKTPFVASNLLEKLSRQIQVMEKLSAVSDENIGNISSVIEAIPEFHKKLSLLSFWTKCCTPIGVYHSSADRVIKQLEASFARTVNRDYPGLADPVFHTLVSQILDRAEPLLPASLSSEVITVFQYYSYFTSHGVSDLESYLNQLAKQVSVVQTLQSLRDEKLLQAVSDLAPGSFPAPQEEVLRTLALLLTGEDSGASEAVTLYLTAASRSEHFREKALLYYCEALTKTDFRLQKAACLALKSLKATESIKMLVTLCQSDTEEIRNVASETLLSLGEDGRLAYEQLDKFPRDCVKVGGRLASEVATAF

RIPOR2

Rho family-interacting cell polarization regulator 2

602 amino acids

Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization. Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation. Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration. Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion. Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear. Plays a role for maintaining the structural organization of the basal domain of stereocilia. Involved in mechanosensory hair cell function. Required for normal hearing.

Belongs to the RIPOR family.

66.897 kDa

MSIGSHSFSPGGPNGIIRSQSFAGFSGLQERRSRCNSFIENSSALKKPQAKVKKMHNLGHKNSTTPKEPQPKRMEEVYRALKNGLDEYLEVHQTELDKLTAQLKDMRRNSRLGVLYDLDKQIKAVERYMRRLEFHISKVDELYEAYCIQRRLCDGASKMKQAFAMSPASKAARESLTEINRSYKEYTENMCTIEAELENLLGEFCIKMKGLAGFARLCPGDQYEIFMRYGRQRWKLKGKIEVNGKQSWDGEEMVFLPLIVGLISIKVTEVKGLATHILVGSVTCETKDLFAARPQVVAVDINDLGTIKLNLEITWYPFDVEDLTPSTANVSKASALQRRMSMYSQGTPETPTFKDHSFFSNLPDDVFENGTAATEKRPLSFTFGDLPYEDRVPPANPAEPSSAHVSSSPDITTAATQHRALKSSESSSPDCSSSDSCGDAVPEPKDLPSPGEAVVTGNKVTPRARSEVCQKPSNAGSDRVFIEANVPVSLLQDTDEGSELKPVELDTYEGNITKQLVKRLTSAEVPGTPERLPCEGSISGESEGYKSYLDGSIEEALQGLLLALEPHKEQYKEFQDLDQEVMHLDDILKVSTFSESTTLKDI