RIOX2

Ribosomal oxygenase 2

465 amino acids

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.

Belongs to the ROX family. MINA53 subfamily.

52.8 kDa

MPKKAKPTGSGKEEGPAPCKQMKLEAAGGPSALNFDSPSSLFESLISPIKTETFFKEFWEQKPLLIQRDDPALATYYGSLFKLTDLKSLCSRGMYYGRDVNVCRCVNGKKKVLNKDGKAHFLQLRKDFDQKRATIQFHQPQRFKDELWRIQEKLECYFGSLVGSNVYITPAGSQGLPPHYDDVEVFILQLEGEKHWRLYHPTVPLAREYSVEAEERIGRPVHEFMLKPGDLLYFPRGTIHQADTPAGLAHSTHVTISTYQNNSWGDFLLDTISGLVFDTAKEDVELRTGIPRQLLLQVESTTVATRRLSGFLRTLADRLEGTKELLSSDMKKDFIMHRLPPYSAGDGAELSTPGGKLPRLDSVVRLQFKDHIVLTVLPDQDQSDEAQEKMVYIYHSLKNSRETHMMGNEEETEFHGLRFPLSHLDALKQIWNSPAISVKDLKLTTDEEKESLVLSLWTECLIQVV

Riox2

Ribosomal oxygenase 2

465 amino acids

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39' (By similarity). May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.

Belongs to the ROX family. MINA53 subfamily.

53.517 kDa

MPKKVQPTGDENEEASVPCKRVKEELPETLSVLNFDSPSSFFESLISPIKVETFFKEFWEQKPLLIQRDDPVLAKYYQSLFSLSDLKRLCKKGVYYGRDVNVCRSISGKKKVLNKDGRAHFLQLRKDFDQKRATIQFHQPQRYKDELWRIQEKLECYFGSLVGSNVYMTPAGSQGLPPHYDDVEVFILQLEGTKHWRLYSPTVPLAHEYSVESEDRIGTPTHDFLLKPGDLLYFPRGTIHQAETPSGLAYSIHLTISTYQNNSWGDCLLDSISGFVFDIAKEDVALRSGMPRRMLLNVETPADVTRKLSGFLRTLADQLEGREELLSSDMKKDFVKHRLPPFFEGNGTETMDPGKQLPRLDNIIRLQFKDHIVLTVGPDKNPFDEAQQKVVYIYHSLKNVRQMHMIGEEEESEIFGLRFPLSHVDALKQIWCGSPIRVKDLKLDTDEEKENLALSLWSESLIQVL

RIOX2

Ribosomal oxygenase 2

465 amino acids

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles (By similarity).

Belongs to the ROX family. MINA53 subfamily.

52.614 kDa

MPKKAKPAGSGKEEGPVPCKQMKVEAAGGPSALNFDSPSSLFESLISPIKTETFFKEFWEQKPLLIQRDDPALATYYGSLFKLTDLKSLCSRGMYYGRDVNVCRCVNGKKKVLNKDGKAHFLQLRKDFDQKRATIQLHQPQRFKDELWRIQEKLECYFGSLVGSNVYITPAGSQGLPPHYDDVEVFILQLEGEKHWRLYHPTVPLAREYSVEAEERIGRPVHEFMLKPGDLLYFPRGTIHQADTPAGLAHSTHVTISTYQNNSWGDFLLDTISGLVFDAAKEDVELRAGIPRQLLLQVESTTVATRRLSGFLRTLADRLEGTKEVLSSDMKKDFIMHRLPPYSAGDGAELSTPGGKLPRLDSVVRLQFKDHIVLTVLPDQDQSDEAQEKMVYIYHSLKNSREIHMMGNEEETESHGLRFPLSHLDALKQIWNSPAISVNDLKLTTDEEKESLVLSLWTECLIQVV

Riox2

Ribosomal oxygenase 2

465 amino acids

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39' (By similarity). May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.

Belongs to the ROX family. MINA53 subfamily.

53.216 kDa

MPKKVKPTGDENEEESVPCKQVKEELPNTLSVLNFDSPSSFFESLISPIKVETFFKEFWEQKPLLIQRDDPSLAAYYQSLFSLSDLRSLCSQGLYYGRDVNVCRCIGGKKKVLNKDGKAQFLQLRKDFDQKRATIQFHQPQRFKDELWRIQEKLECYFGSLVGSNVYMTPAGSQGLPPHYDDVEVFILQLEGRKRWRLYSPTVPLAREYSVEPEDRIGTPTHDFLLKPGDLLYFPRGTIHQAETPSGLAHSIHLTISTYQNNSWGDYLLDSISGLVFDIAKEDVALRTGMPRRMLMNVETPADVTRKLSGFLRTLADQLEGRKELLSSDMKKDFVMHRLPPFCVGNGTESMNPGGKLPRLNSIVRLQFKDHIVLTVGPDQNQSDEAQQKVVYIYHSLKNERQTHMMGKEVETEIYGLRFPLSYVDALKQIWCGSPVRVKDLKLGTDEEKENLAVSLWTECLVHVL

RIOX2

Ribosomal oxygenase 2

462 amino acids

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles (By similarity).

Belongs to the ROX family. MINA53 subfamily.

52.455 kDa

MPKKARPAGDGKEQGPAPKQVKVEAACGPSSPLNFDSPSGLFESFISPIKTETFFKEFWEQKPLLIQRDDPALATYYQSLFRLSDLKSLCSWGIYYGRDVNVCRCVHGKKKVLNKDGRVHFLQLRQDFDQKRATIQFHQPQRFKDELWRIQEKLECYFGSLVGSNVYITPAGAQGLPPHYDDVEVFILQLEGEKHWRLYQPTVPLAREYSVEAEDRIGRPTHEFTLKPGDLLYFPRGTIHQADTPEGLAHSTHVTISTYQSSSWGDFLLDTISGLVFDTAKADVALRAGIPRQLLLQAESIAVATRLSGFLRMLADRLEGTKELPSADMKKDFAMNRLPPYYMGDRAKLVAPGGQLPGLDSTVRLQFRDHVVLTVGPYQDPSDETRGEMVYVYHSLRNRRDTHMMGNETESYGLRFPLSYMDALKQIWNSSAISVKDLKLTTDEEKQNLVLSLWTECLIQVV