RIN1

Ras and Rab interactor 1

783 amino acids

Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.

Belongs to the RIN (Ras interaction/interference) family.

84.099 kDa

MESPGESGAGSPGAPSPSSFTTGHLAREKPAQDPLYDVPNASGGQAGGPQRPGRVVSLRERLLLTRPVWLQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEASGPSFVSSHYILESPGGVSLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATHKELEAISHLGIEFWSSSLNIKAQRGPAGGPVLPQLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREKFKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAGSGPSLPPMPSLQEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRRPLLRSMSAAFCSLLAPERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPEPQELQGIRQALSRARAMLSAELGPEKLLSPKRLEHVLEKSLHCSVLKPLRPILAARLRRRLAADGSLGRLAEGLRLARAQGPGAFGSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQEGEGAGADEFLPLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALLSGLGQAHTLPLSPVQELRRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEASIATLNQLCATKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRLPTTGYLVYRRAEWPETQGAVTEEEGSGQSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGPAQPGEPEAEGSRAAEE

Rin1

Ras and Rab interactor 1

774 amino acids

Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis (By similarity).

Belongs to the RIN (Ras interaction/interference) family.

84.727 kDa

MEDPGETEAHPLGATSLNFVPGYQQEEKPSPDPLYDTPDARGVQAGGSQQPARTVSLRERLLITRPVWLQLRANAAAALHVLRTEPPGTFLVRKSNTRQCQTLCVRLPEASGPSFVSSHYLQESPGGISLEGSELTFPDLVQLICAYCHTRDILLLPLPLPRAIHQAATHKELEAISHLGMEFWSSSLNTKNQQRPSEAPQIPRLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREKFKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGTSSSQTERLPPRQLLQRESSVGYRVPGSASGPSLPPLPSLQEVDCCSPSSSEEEGSSGSPTTSPRLSRPRHRRPLLRSMSSAFCSLLAPERQVGRAATMLMQNRYTAVGQLVQDLLTQVRVGPESRELQGIRQALSRARAMLSAELGPEKLLPPERLELVLEKSLHRSVLKPLRPILAARLRRRLSTDGSLGRLAEGFRLARTQGPGAFGSHLNLSSPVEIEPVRQKLLQLLRAYSPSAQIKWLLQACKLLYTALKTQAGENAGADEFLPLLSLVLAQCDLPDLLLEAEYMSELLEPTLLTGEGGYYLTSLSASLALLSGLSQAHALPLSPAQELQRSLALWEQRRLPATHNFQHLLRVAYQDPSTGCTSKTLAVPPGSSIATLSQLCATKFRVTQPDAFGLFLYKDQGYHRLPPEALVHRLPTTGYLIYRRAERPETQRAATEKTKTGNERPERGAWEEEKGGLNGEGKSEIAVDQEGKDQARGGHMQLEEQKAEGCPALEE

Rin1

Ras and Rab interactor 1

763 amino acids

Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis (By similarity).

Belongs to the RIN (Ras interaction/interference) family.

83.014 kDa

MEDPGETGAHPLGATNLNFVPGHQQKEKPSTDPLYDTPDTRGVQAGGSQQPARTVSLRERLLITRPVWLQLRANAAAALHVLRTEPPGTFLVRKSNTRQCQALCVRLPEASGPSFVSSHYIEESTGGVSLEGSELMFQDLVQLICGYCRTRAIHQAATHKELEAISHLGMEFWSSSLNTKDQQRPSEAPPIPRLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREKFKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGTSSSQTERLPPRQLLQRESSVGYRVPGSAASPCLPPLPSLQEVDCCSPSSSEEEGSSGSPTTSPRLSRPRHRRPLLRSMSSAFCSLLAPERQVGRAATMLMQNRYTAVGQLVQDLLTQVRAGPEPRELQGIRQALSRARAMLSAELGPEKLLPPERLELVLEKSLHRSVLKPLRPILAARLRRRLSADGSLGRLAEGFRLARTQGPGAFGSHLTLSSPVETEQVRQKLLQLLRAYSPSAQVKWLLQACKLLYTALKSQAGENAGADEFLPLLSLVLAQCDLPDLLLEAEYMSELLEPTLLTGEGGYYLTSLSASLALLSGLSQARALPLSPAQELQRSLALWEQRRLPATHSFQHLLRVAYQDPSTGCTSKTLAVPPGSSIATLSQLCATKFRVTQPDAFGLFLYKDQGYHRLPPEALAHRLPATGYLIYRRAERPETQGAVAEKAKTGSKGPEAGAWEEETGGLNREGKPRIAVDQEGKDQARGGHIGPEEQKAEGSQALEE

RIN1

RuvB-like protein 1

458 amino acids

Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. Has single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity).

Belongs to the RuvB family.

50.323 kDa

MEKVKIEEIQSTAKKQRIATHTHIKGLGLEPTGIPIKLAAGFVGQLEAREAAGLVVDMIKQKKMAGKALLLAGPPGTGKTALALGISQELGSKVPFCPMVGSEVYSSEVKKTEVLMENFRRAIGLRIKETKEVYEGEVTELSPEETESLTGGYGKSISHVVITLKTVKGTKHLKLDPTIYDALIKEKVAVGDVIYIEANSGAVKRVGRSDAFATEFDLEAEEYVPLPKGEVHKKKEIVQDVTLQDLDAANARPQGGQDILSLMGQMMKPRKTEITDKLRQEINKVVNRYIDEGVAELVPGVLFIDEVHMLDMECFSYLNRALESSLSPIVIFATNRGVCNVRGTDMPSPHGVPIDLLDRLVIIRTQIYDPSEMIQIIAIRAQVEELTVDEECLVLLGEIGQRTSLRHAVQLLSPASIVAKMNGRDNICKADIEEVTSLYLDAKSSAKLLHEQQEKYIS