RIM13

Gene

RIM13

Protein

Calpain-like protease palB/RIM13

Organism

Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)

Length

814 amino acids

Function

Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.

Similarity

Belongs to the peptidase C2 family. PalB/RIM13 subfamily.

Mass

89.673 kDa

Sequence

MPFCSYQEGLKVASDLGNKAIQTEASLSSLSPVASPIPTLQKAFPIYISAAEAYGHLLSSKLVPQSDIETVKRKWRLVLERAEKVKSRIEQLGGHVAKAEIGDRGEEIAVLRRASLINGVAVELWRPPGDTFDAGEPYREAVQPELAAAQLDMDPEWRDIQADCWLHQAPNEGDWVMRQGPVSDCSVVAAMGVGIKHAGQFGTAFGWENLYPQDAHGRPRRSKNGKHILKLLLNGAWRSVVLDSLLPFSKRDKTPLFTTCHPAPHILPTSVGSPWAPLALKGYFKVHGGYSLRGSNPSSDIYEFMGWIPERIGLKEGFQREKEWKRMKEAWHKGNVMVSLGTGSKVSEGLVKLHAYGVIRLREEGHERILDIFDPGATSFTMSWDQVCAEFEALHLNWKPSVMPNTATRHWSWPKPPDLPSDADPGMMNTRYRLHVNASSPSSSLSEVWILLSQHITSRDRPLDDIALHVFEGLGPNNSRNLGAIYSEGLERTNPYTNSNHLLVRYQLRRPTSDLTLIPSRDRGIDQTGFTLNAFAPASISLSLERISRTLPFTQRISGNLTDRSAGGHPGWPTHMTNPQYKVVVRPGEGKSEISGRIILHGEKDVPWNVKLIWGRGQLVYELSEDLIVADTGSYSYGIAYCDIPELQPDTYTLIVSAFEPGQTGLFSLSLEATAPVSIIPIAAEGAGMYNRVVNGFWTERTAGGRPSGGTYESNPRVEMVLSKPATIQSRLYLPTRSPVPINLTIFKRAQGGALGEQLVTTGPYSDSICGVSTGKMKLDSGVYLLVPSSYEKSKGGWVLKIWSDVALSAEIVG

Protein

Calpain-like protease palB/RIM13: RIM13

Gene

RIM13

Protein

Calpain-like protease palB/RIM13

Organism

Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)

Length

814 amino acids

Function

Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.

Similarity

Belongs to the peptidase C2 family. PalB/RIM13 subfamily.

Mass

89.673 kDa

Sequence

Protein

Calpain-like protease palB/RIM13: RIM13

Gene

RIM13

Protein

Calpain-like protease palB/RIM13

Organism

Yarrowia lipolytica (strain CLIB 122 / E 150)

Length

795 amino acids

Function

Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.

Similarity

Belongs to the peptidase C2 family. PalB/RIM13 subfamily.

Mass

89.799 kDa

Sequence

MSLPEEIYTSAMLAIACNDDKKAQEILVSLLQTYPDLVDYAKSISPATGKLVLRQAKRSMDAYDSIKKGGSVLSLAEKIVYLSSRTNYGYALPWEYATPVSALKKSDDLYVDATDGGLRQSQHRDVSWLRIPHVFASSDAVFTWSGFETLYQDGLENCSFVASLLSIGVMEKRCNYSLLKEALLDKSSNHHLGTPPSSGRYDIKLFINGCDRRITIDDRFPIREPSLPNMYLRSYTNPTLVWPALLEKAFMKVLDGYDYAGSHAGGDTFVLCKWFPEFVSLTSYHDTNGLWRYIYDSWLQGDVLLCLGTGSFSREEADYKGLLGEHDYAVLELREIQDGCNTAHILRIRDPLLFGPFSNPKNPLVEESNRLAKLVDGKNVDMASRGEIWMDFNQATREYQSLYLNWRPERFFCRLEQHFFWKTSDIMDFQMCGSFVQNPQYTITNNGTKTATGKLVLLRHTQGRETDAKSFCCIHLFEGATRVVLQETSHAVYKGKLMNLHYYTVSLTLKPGESTTAVMACSGMTDSEPMYRFSLFLYANNPLTMSKPTAPLAYSQIFKGKWSEDQAGGNWAKPMYIHNPQFLLTVNEHCDQLYIYLTSSSRQPIAAQLFWGSKSLKEYKESAIETSSGKYKTGSTHLKTRNIDAGSNLILIISTFDSAPQTDYNIRVFSSGNFSLTQLARHTAGKFTKSHKSKFYNSCSEQVEFSVQQSTQHLSLAARMIKTRPFIRLTIREAQSNTVVATTNTFSDSIYGVHLDGVRVSRGLVYLAVIEKMEHSNNEPYVMEFAADTLVTLGH

Protein

Calpain-like protease palB/RIM13: RIM13

Gene

RIM13

Protein

Calpain-like protease 1

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Length

727 amino acids

Function

Required for the proteolytic cleavage of the transcriptional repressor RIM101 in response to alkaline ambient pH, which is necessary for sporulation and invasive growth. Probably the protease that cleaves RIM101.

Similarity

Belongs to the peptidase C2 family. PalB/RIM13 subfamily.

Mass

83.124 kDa

Sequence

MNDWHEFNAAIKSIYCNAEGDSSSIINRLVGLAMKSEDSTFIEAVLVLKENVSKVDKQLRFLWLTSTINSRFYPPIPISEASPVSWNKTEYCAPGTEELQRRYPGRAKLQNEEDYSGGIEQCRDVPDCSLVASLINLRSKNLNLPLIKQISSTKYHVNLSFNGSNKRLVTVDISQIPTSVDGKQLSLKSNDISDKIGELALLLVSKGTYSTDGSNISIDTYRLSGFLPEITQVNSYPFEKLWKFHKSNLCLMGAGTGNRSNDMIKPLVENHDYSIIDITYDSRLVKLRDPRNSALNVEISYEQYLKNFKQLYLNWNQEKLFKRSQVLHFRYDTSRYNKFSIVADKPLFHLVNNSKVTETVWLLLESHLQDEGSQENRSVSFLNEAPECIICPIEPPVECGGNHIGLQLVKLRLDAETERLLYCYSTTNNNFSIHSFSVVKEICFQRLKDTKSLFAKVLFSFPYEIEGKASFDTCNFFQNPTFELEVHSEQDYQVLMDAACISTSSHDLINIQVYYFNDYELIKPIMFDNHYQPGQGLKQDVPILTNVKYMIVCSTYGPPASTEFELLASIRLSSSWRLISGITLRSVNLIYGTYPYHCRNRFHWKETSDKLKIQMTLPTKKYSTNKLFIRVVPVESSARLRMRCNIFEPESALCVYECQEYRTCPSGGIVIPDLEVSRTNIVVLMIERSVPISSCLPTEGQLDELELFVGSSQKIRIEKYSDDVIPK

Protein

Calpain-like protease 1: RIM13

Gene

RIM13

Protein

Calpain-like protease palB/RIM13

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876)

Length

717 amino acids

Function

Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.

Similarity

Belongs to the peptidase C2 family. PalB/RIM13 subfamily.

Mass

83.07 kDa

Sequence

MPTPCLEQFLHHLEKSHLYLSIDNTKQAKKECLESIKILNSIAKTTPLPEIKVLSQYTLNHYESLDKPRTISDKLEWISSKLTQETFFPPVIQFNENFTSHNELFVDTISPIQDNDNKIFEKLPNKLAKFEYIEISNWDNDITHLKNLYQDILPNCSFVSSFLAIIDANIPIIDTITPQKSSQKYKVSLRFNGALRNVIVDSKFPIMPNSRNLIIKSYSDTELYWPALIEKAYLTIMGNGYNFSGSNMANDAYVLSGWLPQIIKLSNGQLPSNIDDLWRLRTQGKVTMGIGTGTLSKQLSSQLHLVSGHDYVIDNIKDGVITVKNPWLDPKDRVVEIKNFNHFKYLYVNWKPDHKPYQHYFLYQAKPNTYNQPQFTIKCMEETWILLERHLSETSSSPSPHWMDMNVFETEYKIITPSQYKKYLSVETNNRLQLIKLKPGVFTIVISSNKPCRFTLSSFNAMFSKSKYKYDYTETVNGEWNSDINGGNWAMSTYINNPQYDIIAKQTTELIMGMHGQGQINFHLFHSSSDSMGERIQNFDKTKLINYQNYNASYQSSSYRLTPGHYKLVVSEYYRSIGTYQLVLNSSEPITITKIPPFLGLYNISKSFNWDNTNRFKLKFETTGYNSKVKIKIAYFNGESDFELQTSYRPAMRASLFNSQTKQPIQINEQFNDSLYGVFLHEILPSPEEYILLIERFEIGYGRCVVEIGCNNKVILK

Protein

Calpain-like protease palB/RIM13: RIM13

Gene

RIM13

Protein

Calpain-like protease palB/RIM13

Organism

Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)

Length

713 amino acids

Function

Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.

Similarity

Belongs to the peptidase C2 family. PalB/RIM13 subfamily.

Mass

82.519 kDa

Sequence

MNVDRCWEQYYKTLKLIYLEENKETCQREIDHLVDTAIELKEKTYSNAVLDLGRQFREVCPKARIMWKTSSIAGNFYPPISISDIYSPVIANVFDQTTRLECRRQEYSLRMPLQEEPNFTGIQQHAQVSDCSLVVSLININRYKTTMPVVKQVAENLYATNLYFNGAQRRLVLVSTENIPTMQDDPTKQMSVHSANKINKILELGLLKLTSLSYHSEGSNTAIDTYRLCGWIPDISSINEFNFLKVHKAFSRGECLIAMGTGGFVPKENIFGVKLRKYHDYAVLDIDMINEVVTLRDPLISDTLLTINFDSIRKYFLQVYCNWDSSKLFMFTKDTQIFYSDKKFNPYQTLAGKPTFYLKNNSDRDEYAWVLLEFHLDKNNNTTAYLQEIPDRISTVRLGYNDNSAETGFQLIKIRLKPKQCIWYFCYSSTDKMLTFHTYSTSSDVVFVRSKMPGCDFDVTECAILPENIVPMQYPNHSETDIYYLASIDFSIEGEPGITIITDMVVCLETDDDLVNFQMFHWDDLDFNSPIYDEFYMNERMFEKKDLPLTSGERYRIVASTARPPISKGYQCAVSGINIHADYPCSYKLRESDVRYNSMMFKLPHVFTLASTGITKISLVNRNKYNKVFMRIYPQTQEDYRYNYRVISADTGEDLVKPGNNIQKLYGGIVIKEFLVSDQTNLELHLSFQDNGRVPVELKCQLYVGSVKIITLS

Protein

Calpain-like protease palB/RIM13: RIM13

Gene

RIM13

Protein

Calpain-like protease palB/RIM13

Organism

Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)

Length

694 amino acids

Function

Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.

Similarity

Belongs to the peptidase C2 family. PalB/RIM13 subfamily.

Mass

78.836 kDa

Sequence

MEALLAVEETGNDLWKELKELYWAQYVQNSVDKVQFERYVRKVKSADDYWLVRALLAFSDSRKACTFNSRFEWLTMQAHGRQYPPLASKDAGKLIWNARREFRYAEPQQAAYKQLARPRGDAVADIQQHPDLGNCSMVCALINVKRTCGTADMVADCGDVAQVNLFFNGARRLVTLHRAEVRQNMRREQLAVLSPDMHDKLIEQAYFEVAHGMNYESMGSNTAMDTYMLCGWFPLVVETSEVDFPFVQRYLARGAMLALGTHATRTIDSFCLRKNHDYAVLDVCGTVFRIRDPLVAGNVIELAWEDVRTAFHLLYINWDAHTQCQLYEKFHFRYNSAVHNRFMSWLNKPTYRVVNDTESELPVYALFERHLSNRKYDNSIVGVISGENLVSDTEEGNNIGMQWVELTVPPHSSRILFYHSNTNTNCTLHLFSNSPRLKVAKWSSAESSRLAVLDGCWQPISKNLTFTHWPAFKFEIKHPETDGVHVSLQFCWANEHSAALFIYHASDYRYEKPLLHRPGPLPFPQAFFELALDTNTPYVVLCQSMDVGADAAFQLAIQTEKQGSVISTVPTSRAYGGLRFHTSKLVSTAAKRIELPFKVSRSTDLHITLYSKSSPLVLKCAVFSDGSDEAITATPGFVPINDYPYVLPITFAKERSLVLLIELQDTVPDSTVTIEIGSNCAFNFCGHDVDLARV

Protein

Calpain-like protease palB/RIM13: RIM13

Gene

RIM13

Protein

Calpain-like protease palB/RIM13

Organism

Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)

Length

685 amino acids

Function

Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.

Similarity

Belongs to the peptidase C2 family. PalB/RIM13 subfamily.

Mass

79.686 kDa

Sequence

MPRGAQAMLEKQADSVWNQLYEICWNFYVKNVWDINTFKAIVDKIEKSDDKQLIRFLIWFNDARKRSNFNDKFQWMTSFLYGRRYPPLGDDLVVKEPWNDLQQLDSIIKYGNEPIDLVKMQPDFTTEERIVQNRRVNNCSLICSLTNAREENQIKSYSVHNVFNVILHFNGSNRLVSVLRDSNFPKCSKDGAALTLFSHNIEDMLIELAYFEIKNNRNYAYGGSNTATDTYLLTGWIPEILNLGDVSFSEIRKCYQFNAMLALGTDSVKGKEVTENHDFVVTSVNWKKEQFTILNPHGTENPTVYTWDDLIKEFKWLYVNWDPYSKYTQRVKLHDRYPDKFNAYPTWTQKPLMCIENKSNSIQNCHLYLERHLLDDSILESNLTIGEIPRSGFTAVSAEGNNSGFCNMQLRLNPHETRLIFYHSDKKCNLTFHLLSNSGLVSMSKCKSDILTAESSWNITNNQWTIGTSEYFKSPVFKLKSDGFDDTYLDFELVSQLPAKVNFQIFESDDYALQRPIFKNDTYSPQIFSKHGVRLLKGREYFIVCSIAHHITSPFIFTLRNPETKQSKFELSPYSLGFGGLRYNEVLRCKTRITISVSNFTRLFVLLFTSASKTNGRLTLRLYEKETEEILFEQIETRYDLSVKPFPIPNIELKPASYVLEIFYNADVVICNLGTSHRAIFESDL

Protein

Calpain-like protease palB/RIM13: RIM13