RECQL5

ATP-dependent DNA helicase Q5

991 amino acids

Isoform beta is a DNA helicase that plays an important role in DNA replication, transcription and repair. Inhibits elongation of stalled transcripts at DNA damage sites by binding to the RNA polymerase II subunit POLR2A and blocking the TCEA1 binding site. Required for mitotic chromosome separation after cross-over events and cell cycle progress. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination.

Belongs to the helicase family. RecQ subfamily.

108.858 kDa

MSSHHTTFPFDPERRVRSTLKKVFGFDSFKTPLQESATMAVVKGNKDVFVCMPTGAGKSLCYQLPALLAKGITIVVSPLIALIQDQVDHLLTLKVRVSSLNSKLSAQERKELLADLEREKPQTKILYITPEMAASSSFQPTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRLGALRSRLGHAPCVALTATATPQVQEDVFAALHLKKPVAIFKTPCFRANLFYDVQFKELISDPYGNLKDFCLKALGQEADKGLSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTLVQNDWMEEKVPVIVATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCRLYYSRNDRDQVSFLIRKEVAKLQEKRGNKASDKATIMAFDALVTFCEELGCRHAAIAKYFGDALPACAKGCDHCQNPTAVRRRLEALERSSSWSKTCIGPSQGNGFDPELYEGGRKGYGDFSRYDEGSGGSGDEGRDEAHKREWNLFYQKQMQLRKGKDPKIEEFVPPDENCPLKEASSRRIPRLTVKAREHCLRLLEEALSSNRQSTRTADEADLRAKAVELEHETFRNAKVANLYKASVLKKVADIHRASKDGQPYDMGGSAKSCSAQAEPPEPNEYDIPPASHVYSLKPKRVGAGFPKGSCPFQTATELMETTRIREQAPQPERGGEHEPPSRPCGLLDEDGSEPLPGPRGEVPGGSAHYGGPSPEKKAKSSSGGSSLAKGRASKKQQLLATAAHKDSQSIARFFCRRVESPALLASAPEAEGACPSCEGVQGPPMAPEKYTGEEDGAGGHSPAPPQTEECLRERPSTCPPRDQGTPEVQPTPAKDTWKGKRPRSQQENPESQPQKRPRPSAKPSVVAEVKGSVSASEQGTLNPTAQDPFQLSAPGVSLKEAANVVVKCLTPFYKEGKFASKELFKGFARHLSHLLTQKTSPGRSVKEEAQNLIRHFFHGRARCESEADWHGLCGPQR

Recql5

ATP-dependent DNA helicase Q5

982 amino acids

DNA helicase that plays an important role in DNA replication, transcription and repair. Inhibits elongation of stalled transcripts at DNA damage sites by binding to the RNA polymerase II subunit POLR2A and blocking the TCEA1 binding site. Required for mitotic chromosome separation after cross-over events and cell cycle progress. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination (By similarity).

Belongs to the helicase family. RecQ subfamily.

108.246 kDa

MSARPFSTPFDRERRVRSTLKKVFGFDSFKTPLQESATMAVVKGAEDVFVCMPTGAGKSLCYQLPALLASGITIVVSPLIALIQDQVDHLLALKVQVSSLNSKLSVQERKELLSDLERDKPRTKLLYITPEMAASASFQPTLNSLVSRNLLSYLVVDEAHCVSQWGHDFRPDYLRLGALRSRLAHAPCVALTATATPQVQEDVFAALHLKQPVASFKTPCFRANLFYDVQFKELIPDVYGNLRDFCLKALGQKAENGSSSGCGIVYCRTREACEQLAIELSSRGVNAKAYHAGLKASDRTQVQNEWMEEKVPVIVATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCRLYYSRNDRDQVSFLIRKELAKLQEKRGNKPSDKATLLAFDALVTFCEEVGCRHAAIAKYFGDAPPACAKGCDYCQNPAAITKKLDALERSSSWSKTCIGPSQGNGFDPELYEGGRRGYGGFSRYDEGSGGSGDEGRDEAHKREWNLFYQKQMSLRKGKEPKIEEFTPPDEDCPLREASSRKIPKLTVKAREHCLRLLEEALISNHQAAGSTHGADLQAKAVELEHETFRNAKMVNLYKASVLKKVAEIHKASKDGQLYDMESGTKSCGAAAEFSEPSDYDIPPTSHVYSLKPKRVGAGFSKGPCSFQTATELLGKSHSQKQAPEAMLEGGQEPPGWVCDLQDEDRSKPHPGYQEKALGSSVNCGDPSPEKKTKGSSQGSAKARASKKQQLLATAARKDSQNITRFLCQRTESPPLPASVPRSEDASPSCGDVPGKCTQEVGAQGHLVAVFQTEGPRERPSTCSLRDQSFPEGQPSPLKETQAEKRPRPQQGNPERRAQKRLRPSTKSSILAEAKDSTLASDRSTENKVAQEPCQLSASGTSLREAADIVVRHLTPFYKEGRFISKDLFKGFARHLSHLLAQQLSPGRSVKEEAQSLIKQFFHNRARCESEADWHSLRGPQR

Recql5

ATP-dependent DNA helicase Q5

973 amino acids

DNA helicase that plays an important role in DNA replication, transcription and repair. Inhibits elongation of stalled transcripts at DNA damage sites by binding to the RNA polymerase II subunit POLR2A and blocking the TCEA1 binding site. Required for mitotic chromosome separation after cross-over events and cell cycle progress. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination (By similarity).

Belongs to the helicase family. RecQ subfamily.

107.222 kDa

MSARPFSTPFDRERRVRSTLKKVFGFDSFKTPLQESAIMAVVKGDKDVFVCMPTGAGKSLCYQLPAVLAKGITIVVSPLIALIQDQVDHLLALKVQVSSLNSKLSVQERKELLSDLERDKPRTKLLYITPEMAASASFQPTLNSLLSRNLLSYLVVDEAHCVSQWGHDFRPDYLRLGALRSRLAHAPCVALTATATPQVQEDVFAALHLKQPVASFKTPCFRANLFYDVQFKELIPDVYGNLRDFCLKALGQKADNGSSSGCGIVYCRTREACEQLAIELSSRGVNAKAYHAGLKASERTQVQNEWMEEKVPVIVATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCRLYYSRNDRDQVSFLIRKELAKLQEKRGNKPSDKATLLAFDALVTFCEEVGCRHAAIAKYFGDAPPACAKGCDCCQSPAAIRKKLDALEHSSSWGKTCIGPSQGDGFDPELYEGGRRGYGGFSRYDEGSGGSGDEGRDEAHKREWNLFYQRQMSLRKGKEAKPEEFTPPGEDCPLRDASSRKIPKLTVKAREHCLRLLEEALNSNHQAAGSTHGADLQAKAVELEHETFRSAKMVNLYKASVLKKVAEIHKASKDGQLYDMESSTKSCGAIAELLEPSDYDIPPTSHLYSLKPKRVGAGFSKGPCPFQTATELLGKSQTEKLAPEAALESEQEPSGWVCDPQDGDRSKPCLGYQEEAPGSRTNCGDPSPEKRTKGSSQGSAKARASKRQQLLATAARKDSQSITRFLRQRTECPPPAASVPSSEDASPCGDVPGKCTEEVGAQGHLVAVFQTECPRERLSTCSLEDQSLPKGQPSPLKETQAEKRPRPQQESQEKRAQKRLRPSTNSSALASDPSTENRVAREPCQLSAPGISLKEAADIVVRYLTPFYKEGRFISKDLFKGFARHLSHLLAQKLSPGRSVKEEAQSLIKQFFHNRARCESEADWHGLCGPQR

RECQL5

ATP-dependent DNA helicase Q-like 5

911 amino acids

3'-5' DNA helicase that may play a role in the repair of DNA.

Belongs to the helicase family. RecQ subfamily.

100.755 kDa

MDFDSDSDGSHVSATPPRDSFPSSPPQLQSPAKHVPPVSRKMTSSSSRSKPKAPTHPPPNPSQEAPVPSPYPPPPPPSPLFTNLPFRICQSQPARFSSSVSSFSRLCSRASFTSVEKLKSDGVDFVPEPPLVEVIAPPKSVRRKPPNLITDTITSPPVKPMVFRSNGNGEGNFVKLNLNGKRGKKFPSKYKGVSKSRSSYSFRGKRYKKKEADGDGESLLEEESDLQKQIEDEANGFISSVEDAILAVKTEASDENLTKLLNLVYGYDSFRDGQLQAIKMILGGSSTMLVLPTGAGKSLCYQIPAMILPGITLVVSPLVSLMIDQLKHLPSIIKGGLLSSSQRPEEATETLRKLKEGIIKVLFVSPERLLNVEFLSMFRMSLSVSLVVVDEAHCVSEWSHNFRPSYMRLKASMLFSELKAECILAMTATATTMTLQAVMSSLEIPSTNLIQKSQLRDNFELSVSLSGANRMKDLLILMESPPYKEIRSIIVYCKFQYETDMISKYLRDNNINAKGYHSGLPAKDRVRIQESFCSNKIRVVVATVAFGMGLDKGDVGAVIHFSVPGSMEEYVQEIGRAGRDGRLSYCHLFYDNDTYLKLRSLAHSDGVDEYAVGKFLTHVFSTETKQHEKICSLVIESASQKFDMKEEVMQTILTHLELGEVQYLRMLPQLNICCTLNFHKSSPNTLAARSAIVAAILKKSHVKQGLHVFDIPAVASSICVATTDVLAEIQALKMKGEVTYELKDSAFCYTILKSPKEICSLSSHLTKWLTEIESCKVRKLDIMSSAAVAAISVSNTSELSSGAKQTRSLQSRIFDYFNGDEKCDSPSKATQNCAFLRADIKVFLQSNRQAKFTPRAIARIMHGVGSPAFPNSVWSKTHFWGRYMNVDFRVIMEAAQTELFNFVDRNAALAT