REC114

Meiotic recombination protein REC114

432 amino acids

Required for meiotic recombination events; not required for mitosis.

Belongs to the REC114 family.

48.922 kDa

MYEYCSVVIKKYSKYTIPSFAPNGFCSMLEPPQIDKWQHLSTNCTLQFRVLLMDSGQVLIHVVLNNSTLLENIRLPLGDNQDLIQFSCKCPIISCKYISEEFGPRMLRRFQINLPNDIEFNRAIVSLKNLNFVLRTAKTSIAQNTITSQVLDINNGKKVNFAEGTNTSNYAHSNTQFQTQNMITDFSQRCQEKSEREPSNRSNITLPQDNFPIGQQSWPNTELNVVHSSQDLNTPSATQTVLSRPEPLNVQPSEVSQSLAKTTSCLPNIGNQKNQTETISDLLSRKDIAPCKPGLMEVVHLPKERVEKESRMHSTTGLVKTPTTTVWSLEKENTIRQNSNNKENADNKLSDSQKSRGINTPNRRTEIPLNGTLNGTKEEVSLGGEITVSVKNANRNASRKISKRLIKEKLKDKEFMNWVNKVETVLNKMFEK

REC114

Meiotic recombination protein REC114

431 amino acids

Required for meiotic recombination events; not required for mitosis.

Belongs to the REC114 family.

48.888 kDa

MYEYCSVIIKKYSRYTIPSLAPKGFSSVLEPPHIDKWQHLSVNCTLQFKVLLEDSGQVALQVILNNSTFLEHIRLPLGSNHDSIQFSCKCPIISCKYISEEFGPKVLKRFQINLSNEMDFNRIVISLKNLSFIVKTAKTSIARNTMINQTSDFSNSKKGNFNENNNAGTYRNSSVQFQTQNMVMDFSQIYQEKCARELNNCSNITFPMTNLPMTQQNFPTPEANVEHFSQDLNTPSATQTIPIAPEPLSVKLLEASPPLSNKSRHSPTTKKENRNTAISFDLLSKKGAILHNGNDTLNVADLPKKRQSTEDLVQIRSSANVVTTLGTSCNLVKKNATKQNKEKVDNKLSDSQNVAHTNEYQKKKEIPLCGPINGLETKMTLIQEEMMAAKKTSRDPPRKISKRLIKEKLKDEEFMKWVNKVERVLSKMFEK

REC114

Meiotic recombination protein REC114

428 amino acids

Required for the production of double-strand breaks (DSBs) in meiotic recombination initiation; not required for mitosis. Plays a role in activation of the DSB nuclease SPO11 at recombination hotspots. Prevents accumulation of meiotic double strand break intermediates and is needed for the proper timing of the first meiotic division. Component of the MER2-MEI4-REC114 complex which seems to be required for meiotic double-strand break (DSB) formation.

Belongs to the REC114 family.

48.706 kDa

MYEYCSVVIKKYSKYTIPSFAPNGFQSMLEPPQIDKWQHLSANCTLQFRVLLMDSRQILINVVLNNSTLLENIRLPLGDNQDLIQFSCKSPIISCKYISEEFGPRMLRRFQMNLPNDVEFNRTVVSLKNLNFVLRTARTSIAQSTITSQVQGNNNGTKVCFTEGPKVSSYTNPNTQFQTQNMIMDFSQRYQEESERESNNRSNITLPHDSIQIAQQIWPNTDLNVVQSSQDLNTPMATQTVLGRPESLIVQPLEVSQSPPNTTNCLPNAENKKKKVDTTSDFTSRKEIALCKTGLLETIHIPKERESQMQSVTGLDATPTIIWSPGKDNTAKKNTSNKKNIDDKLTNPQKSGNTHTPDRNKEVLPNGTLNETRKEASPSEGLTIRVKNVNRNASRKISKRLIKEKLKDEEFMKWVNKVETVLNKMFEK

REC114

Meiotic recombination protein REC114

266 amino acids

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1/CCDC36 and MEI4, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis.

Belongs to the REC114 family.

29.155 kDa

MAEAGKVPLSLGLTGGEAAEWPLQRYARCIPSNTRDPPGPCLEAGTAPCPTWKVFDSNEESGYLVLTIVISGHFFIFQGQTLLEGFSLIGSKDWLKIVRRVDCLLFGTTIKDKSRLFRVQFSGESKEQALEHCCSCVQKLAQYITVQVPDGNIQELQLIPGPPRATESQGKDSAKSVPRQPGSHQHSEQQQVCVTAGTGAPDGRTSLTQLAQTLLASEELPHVYEQSAWGAEELGPFLRLCLMDQNFPAFVEEVEKELKKLAGLRN

Rec114

Meiotic recombination protein REC114

259 amino acids

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination (PubMed:20551173, PubMed:27723721). Probably acts by forming a complex with IHO1/CCDC36 and MEI4, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis (PubMed:27723721).

Belongs to the REC114 family.

28.211 kDa

MSEAGNVASGLGLPGEVSQWSLKRYGRFMLLDNVGSPGPSSEAAAAGSPTWKVFESSEESGSLVLTIVVSGHFFISQGQTLLEGFSLIGSKNWLKIVRRMDCLLFGTTIKNKSRMFRVQFSGESKEEALERCCGCVQTLAQYVTVQEPDSTTQELQQSQGPREAGESQGKDPLQQGPSLTLEQHVCMAAGAGVLQERTSVTHRAQSILAPEKLTLAYEGSSWGTEELGPFLRLCLMDQNFPAFVEEVEKELKKITGLRN