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REC114

Gene
REC114
Protein
Meiotic recombination protein REC114
Organism
Saccharomyces paradoxus
Length
432 amino acids
Function
Required for meiotic recombination events; not required for mitosis.
Similarity
Belongs to the REC114 family.
Mass
48.922 kDa
Sequence
MYEYCSVVIKKYSKYTIPSFAPNGFCSMLEPPQIDKWQHLSTNCTLQFRVLLMDSGQVLIHVVLNNSTLLENIRLPLGDNQDLIQFSCKCPIISCKYISEEFGPRMLRRFQINLPNDIEFNRAIVSLKNLNFVLRTAKTSIAQNTITSQVLDINNGKKVNFAEGTNTSNYAHSNTQFQTQNMITDFSQRCQEKSEREPSNRSNITLPQDNFPIGQQSWPNTELNVVHSSQDLNTPSATQTVLSRPEPLNVQPSEVSQSLAKTTSCLPNIGNQKNQTETISDLLSRKDIAPCKPGLMEVVHLPKERVEKESRMHSTTGLVKTPTTTVWSLEKENTIRQNSNNKENADNKLSDSQKSRGINTPNRRTEIPLNGTLNGTKEEVSLGGEITVSVKNANRNASRKISKRLIKEKLKDKEFMNWVNKVETVLNKMFEK

Gene
REC114
Protein
Meiotic recombination protein REC114
Organism
Saccharomyces pastorianus
Length
431 amino acids
Function
Required for meiotic recombination events; not required for mitosis.
Similarity
Belongs to the REC114 family.
Mass
48.888 kDa
Sequence
MYEYCSVIIKKYSRYTIPSLAPKGFSSVLEPPHIDKWQHLSVNCTLQFKVLLEDSGQVALQVILNNSTFLEHIRLPLGSNHDSIQFSCKCPIISCKYISEEFGPKVLKRFQINLSNEMDFNRIVISLKNLSFIVKTAKTSIARNTMINQTSDFSNSKKGNFNENNNAGTYRNSSVQFQTQNMVMDFSQIYQEKCARELNNCSNITFPMTNLPMTQQNFPTPEANVEHFSQDLNTPSATQTIPIAPEPLSVKLLEASPPLSNKSRHSPTTKKENRNTAISFDLLSKKGAILHNGNDTLNVADLPKKRQSTEDLVQIRSSANVVTTLGTSCNLVKKNATKQNKEKVDNKLSDSQNVAHTNEYQKKKEIPLCGPINGLETKMTLIQEEMMAAKKTSRDPPRKISKRLIKEKLKDEEFMKWVNKVERVLSKMFEK

Gene
REC114
Protein
Meiotic recombination protein REC114
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
428 amino acids
Function
Required for the production of double-strand breaks (DSBs) in meiotic recombination initiation; not required for mitosis. Plays a role in activation of the DSB nuclease SPO11 at recombination hotspots. Prevents accumulation of meiotic double strand break intermediates and is needed for the proper timing of the first meiotic division. Component of the MER2-MEI4-REC114 complex which seems to be required for meiotic double-strand break (DSB) formation.
Similarity
Belongs to the REC114 family.
Mass
48.706 kDa
Sequence
MYEYCSVVIKKYSKYTIPSFAPNGFQSMLEPPQIDKWQHLSANCTLQFRVLLMDSRQILINVVLNNSTLLENIRLPLGDNQDLIQFSCKSPIISCKYISEEFGPRMLRRFQMNLPNDVEFNRTVVSLKNLNFVLRTARTSIAQSTITSQVQGNNNGTKVCFTEGPKVSSYTNPNTQFQTQNMIMDFSQRYQEESERESNNRSNITLPHDSIQIAQQIWPNTDLNVVQSSQDLNTPMATQTVLGRPESLIVQPLEVSQSPPNTTNCLPNAENKKKKVDTTSDFTSRKEIALCKTGLLETIHIPKERESQMQSVTGLDATPTIIWSPGKDNTAKKNTSNKKNIDDKLTNPQKSGNTHTPDRNKEVLPNGTLNETRKEASPSEGLTIRVKNVNRNASRKISKRLIKEKLKDEEFMKWVNKVETVLNKMFEK

Gene
REC114
Protein
Meiotic recombination protein REC114
Organism
Homo sapiens
Length
266 amino acids
Function
Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1/CCDC36 and MEI4, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis.
Similarity
Belongs to the REC114 family.
Mass
29.155 kDa
Sequence
MAEAGKVPLSLGLTGGEAAEWPLQRYARCIPSNTRDPPGPCLEAGTAPCPTWKVFDSNEESGYLVLTIVISGHFFIFQGQTLLEGFSLIGSKDWLKIVRRVDCLLFGTTIKDKSRLFRVQFSGESKEQALEHCCSCVQKLAQYITVQVPDGNIQELQLIPGPPRATESQGKDSAKSVPRQPGSHQHSEQQQVCVTAGTGAPDGRTSLTQLAQTLLASEELPHVYEQSAWGAEELGPFLRLCLMDQNFPAFVEEVEKELKKLAGLRN

Gene
Rec114
Protein
Meiotic recombination protein REC114
Organism
Mus musculus
Length
259 amino acids
Function
Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination (PubMed:20551173, PubMed:27723721). Probably acts by forming a complex with IHO1/CCDC36 and MEI4, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis (PubMed:27723721).
Similarity
Belongs to the REC114 family.
Mass
28.211 kDa
Sequence
MSEAGNVASGLGLPGEVSQWSLKRYGRFMLLDNVGSPGPSSEAAAAGSPTWKVFESSEESGSLVLTIVVSGHFFISQGQTLLEGFSLIGSKNWLKIVRRMDCLLFGTTIKNKSRMFRVQFSGESKEEALERCCGCVQTLAQYVTVQEPDSTTQELQQSQGPREAGESQGKDPLQQGPSLTLEQHVCMAAGAGVLQERTSVTHRAQSILAPEKLTLAYEGSSWGTEELGPFLRLCLMDQNFPAFVEEVEKELKKITGLRN