RASGRP1

RAS guanyl-releasing protein 1

797 amino acids

Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768). Activates the Erk/MAP kinase cascade (PubMed:15899849). Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994). Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses (By similarity). May also function in differentiation of other cell types (PubMed:12845332).

Belongs to the RASGRP family.

90.402 kDa

MGTLGKAREAPRKPSHGCRAASKARLEAKPANSPFPSHPSLAHITQFRMMVSLGHLAKGASLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVISSAELLQKVITLYKDALAKNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAKGEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASGVSPKPDPKTISKHVQRMVDSVFKNYDHDQDGYISQEEFEKIAASFPFSFCVMDKDREGLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKRAKNPVAPTENNTSVGPVSNLCSLGAKDLLHAPEEGPFTFPNGEAVEHGEESKDRTIMLMGVSSQKISLRLKRAVAHKATQTESQPWIGSEGPSGPFVLSSPRKTAQDTLYVLPSPTSPCPSPVLVRKRAFVKWENKDSLIKSKEELRHLRLPTYQELEQEINTLKADNDALKIQLKYAQKKIESLQLEKSNHVLAQMEQGDCS

Rasgrp1

RAS guanyl-releasing protein 1

795 amino acids

Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras. Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (By similarity). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses (PubMed:17190838). May also function in differentiation of other cell types. Proto-oncogene, which promotes T-cell lymphomagenesis when its expression is deregulated (PubMed:15829980, PubMed:17210708).

Belongs to the RASGRP family.

90.304 kDa

MGTLGKAREAPRKPCHGSRAGPKARLEAKSTNSPLPAQPSLAQITQFRMMVSLGHLAKGASLDDLIDSCIQSFDADGNLCRNNQLLQVMLTMHRIIISSAELLQKVMNLYKDALEKNSPGVCLKICYFVRYWITEFWIMFKMDASLTSTMEEFQDLVKANGEETHCHLIDTTQINSRDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIHVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSCRNYDNYRRAYGECTHFKIPILGVHLKDLISLYEAMPDYLEDGKVNVQKLLALYNHINELVQLQEMAPPLDANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASGVSPKPDPKTISKHVQRMVDSVFKNYDLDQDGYISQEEFEKIAASFPFSFCVMDKDREGLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKRIKSPAISTENISSVVPMSTLCPLGTKDLLHAPEEGSFIFQNGEIVDHSEESKDRTIMLLGVSSQKISVRLKRTVAHKSTQTESFPWVGGETTPGHFVLSSPRKSAQGALYVHSPASPCPSPALVRKRAFVKWENKESLIKPKPELHLRLRTYQELEQEINTLKADNDALKIQLKYAQKKIESLQLGKSNHVLAQMDHGDSA

Rasgrp1

RAS guanyl-releasing protein 1

795 amino acids

Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:9789079, PubMed:9582122). Activates the Erk/MAP kinase cascade. Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras. Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (By similarity). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses. May also function in differentiation of other cell types. Proto-oncogene, which promotes T-cell lymphomagenesis when its expression is deregulated (By similarity).

Belongs to the RASGRP family.

90.245 kDa

MGTLGKAREAPRKPCHGSRAGPKGRLEAKSTNSPLPAQPSLAQITQFRMMVSLGHLAKGASLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIIISSAELLQKLMNLYKDALEKNSPGICLKICYFVRYWITEFWIMFKMDASLTSTMEEFQDLVKANGEESHCHLIDTTQINSRDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIHVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSCRNYDNYRRAYGECTHFKIPILGVHLKDLISLYEAMPDYLEDGKVNVQKLLALYNHINELVQLQDVAPPLDANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASGVSPKPDPKTISKHVQRMVDSVFKNYDLDQDGYISQEEFEKIAASFPFSFCVMDKDREGLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKRSKSPAVSTENISSVVPMSTLCPLGTKDLLHAPEEGSFIFQNGEVVDHSEESKDRTIMLLGVSSQKISVRLKRTVAHKTTQTESFPWVGGEMPPGHFVLTSPRKSAQGALYVHSPASPCPSPALVRKRAFVKWENKESLIKPKPELHLRLRTYQELEQEVNTLRADNDALKIQLKYAQKQIESLQLGKSNHVLAQMDHGDGT

rasgrp1

RAS guanyl-releasing protein 1

791 amino acids

Functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP.

Belongs to the RASGRP family.

90.172 kDa

MGTVGKKKDRPAHGCSTIPKLALELKQIIHSTTHPKVPAVTPLRVMMPLGKLSKGASLDELIQMCIQAFDLDGNMGQNNELLQIMLTMHGFLIPSTELLIKLRTLYQDAMQNRSFSFCLRICYFIRYWITELWVMFKMDAKLTQTMEEFQELVRSHGEELHWRLIDTAQINSRDWSRKLTQRIQSNCSKKRKVSLLFDHLEPQELAEHLTYLEFKAFRRISFSDYQNYIVNGCVKDNPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVLTKFIHVAQKLHQLQNFNTLMAVIGGLCHSSISRLKDTSSHVSHDVTKVLNEMTELLSSCRNYDNYRRAYNECTNFKIPILGVHLKDLIALHEAMPDFLEESKINVPKLHSLYNHINELIQLQNIAPPLEANMDLVHLLTLSLDLYYTEDEMYELSYAREPRNYRAPPVTPSKPPVVADWASGVSPKPDPKTISKHVQRMVDSVFKNYDLDQDGYISQEEFEKIAASFPFSFCVMDKDREGLISRQEITAYFMRASSICSKLGLGFLHNFQETTYLRPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKELVVFECKKRSKCSMGENNTLSDAGQLEVIPAGGKGLTNDCLGADEGPYSYPNGDGDIHTEVSKDRTIMLMGSSAQKISVRLQPAVKHRATQTENETQSLCLQVPSPPRSRTPDLTSHLPISPMPSPCPSPVPTRKKAYAKWENKDSIRKARAELRGGKAGIQELEKEKVFLKEENTALKIQLKDAHRRVETLRAELRKYVLDSDTHQKGS

rasgrp1

RAS guanyl-releasing protein 1

791 amino acids

Functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP.

Belongs to the RASGRP family.

90.109 kDa

MGTVGKKKDRPTHGCSTIPKLALELKQIIHSTTHPKVPPVTPLRVMMPLGKLSKGASLDDLIQMCIQAFDLDGNMGQNSELLQIMLTMHGFLLPSTELLMKLRTLYQDALQNRSFSFCLRICYFIRYWVTELWVMFKMDAKLTQAMEEFQELVRSKGEELHWRLIDTAQINSRDWSRKLTQRIKPNCSKKRKVSLLFDHLEPQELAEHLTYLEFKAFRRISFSDYQNYIVSGCVKENPTMERSIALCNGISQWVQFMVLSRPTPQLRAEVLTKFIHVAQKLHQLQNFNTLMAVIGGLCHSSISRLKDTSAHVSHDVNKVLNEMTELLSSCRNYDNYRRVYNECTNFKIPILGVHLKDLIALHEAMPDFLEDSKINVPKLHSLYNHINELIQLQNIAPPLEANMDLVHLLTLSLDLYYTEDEMYELSYAREPRNHRAPPVTPSKPPVVADWASGVSPKPDPKTISKHVQRMVDSVFKNYDLDQDGYISQEEFEKIAASFPFSFCVMDKDREGLISRQEITAYFMRASSICSKLGLGFLHNFQETTYLRPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKELVVFECKKRSKLSVGENSSMFDSGQLEVIPAGGKGQTNDCLGAEEGPYSYPNGDGDIHTEVSKDRTIMLMGSSAQKISVRLQPAVKHRATQTENEPQSLCLQVPSPQRSRTPGLTSHLPISPMPSPCPSPVPTRKKAYAKWENKDSIRKARAELRGGKAGIQELEKEKALLKEENTTLKIQLKDAQRRVETLRAELRKYVLDSDVHQTGS