Protein
Ras GTPase-activating protein 4
Function
Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis. Isoform 2 activates the Ras pathway and promotes RANKL shedding by modulating the expression of MMP14.
Sequence
MAKRSSLSIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEDYQVHLPPTFHTVAFYVMDEDALSRDDVIGKVCLTRDALASHPKGFSGWTHLVEVDPNEEVQGEIHLRLEVVPGVHASRLRCAVLEARDLAPKDRNGASDPFVRVHYNGRTQETSVVKKSCYPRWNETFDFELEKGASEALLVEAWDWDLVSRNDFLGKVAVNVQRLCSAQQEEGWFRLQPDQSKSRQGKGNLGSLQLEVRLRDETVLPSVCYQPLVQLLCQEVKLGTQGPGRLIPVIEETTSAECRQEVATTLLKLFLGQGLAKDFLDLLFQLELGRTSEANTLFRSNSLASKSMESFLKVAGMRYLHGILGPIIDRVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLVALLSAICRSVRTCPAIIRATFRQLFRRVRERFPNAQHQNVPFIAVTSFLCLRFFSPAILSPKLFHLRERHADARTSRTLLLLAKAVQNIGNMDTPVSRAKESWMEPLQPTVRQGVAQLKDFIMKLVDIEEKEELDLQRALNSQAPPVKEGPLFIHRTKGKGPLASSSFKKLYFSLTTEALSFAKTSSSKKSTFIKLASIRAAEKVEEKSFGSSHIMQVIYADDVGRAQTVYLQCKCVNELNQWLSALRKASTNNRGLLRSYHPGIFRGDKWSCCHQKDKTDQGCDKTHSRVTLQEWNDPLDHDLEAQLIYRHLLGVEAALRERYQLLRGATEAGVSPTGCDGAPEDSLAQLLRVLQDLREAHGSSLASPAAREPHHLLELQT