RAI1

Retinoic acid-induced protein 1

1906 amino acids

Transcriptional regulator of the circadian clock components: CLOCK, ARNTL/BMAL1, ARNTL2/BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation.

203.352 kDa

MQSFRERCGFHGKQQNYQQTSQETSRLENYRQPSQAGLSCDRQRLLAKDYYNPQPYPSYEGGAGTPSGTAAAVAADKYHRGSKALPTQQGLQGRPAFPGYGVQDSSPYPGRYAGEESLQAWGAPQPPPPQPQPLPAGVAKYDENLMKKTAVPPSRQYAEQGAQVPFRTHSLHVQQPPPPQQPLAYPKLQRQKLQNDIASPLPFPQGTHFPQHSQSFPTSSTYSSSVQGGGQGAHSYKSCTAPTAQPHDRPLTASSSLAPGQRVQNLHAYQSGRLSYDQQQQQQQQQQQQQQALQSRHHAQETLHYQNLAKYQHYGQQGQGYCQPDAAVRTPEQYYQTFSPSSSHSPARSVGRSPSYSSTPSPLMPNLENFPYSQQPLSTGAFPAGITDHSHFMPLLNPSPTDATSSVDTQAGNCKPLQKDKLPENLLSDLSLQSLTALTSQVENISNTVQQLLLSKAAVPQKKGVKNLVSRTPEQHKSQHCSPEGSGYSAEPAGTPLSEPPSSTPQSTHAEPQEADYLSGSEDPLERSFLYCNQARGSPARVNSNSKAKPESVSTCSVTSPDDMSTKSDDSFQSLHGSLPLDSFSKFVAGERDCPRLLLSALAQEDLASEILGLQEAIGEKADKAWAEAPSLVKDSSKPPFSLENHSACLDSVAKSAWPRPGEPEALPDSLQLDKGGNAKDFSPGLFEDPSVAFATPDPKKTTGPLSFGTKPTLGVPAPDPTTAAFDCFPDTTAASSADSANPFAWPEENLGDACPRWGLHPGELTKGLEQGGKASDGISKGDTHEASACLGFQEEDPPGEKVASLPGDFKQEEVGGVKEEAGGLLQCPEVAKADRWLEDSRHCCSTADFGDLPLLPPTSRKEDLEAEEEYSSLCELLGSPEQRPGMQDPLSPKAPLICTKEEVEEVLDSKAGWGSPCHLSGESVILLGPTVGTESKVQSWFESSLSHMKPGEEGPDGERAPGDSTTSDASLAQKPNKPAVPEAPIAKKEPVPRGKSLRSRRVHRGLPEAEDSPCRAPVLPKDLLLPESCTGPPQGQMEGAGAPGRGASEGLPRMCTRSLTALSEPRTPGPPGLTTTPAPPDKLGGKQRAAFKSGKRVGKPSPKAASSPSNPAALPVASDSSPMGSKTKETDSPSTPGKDQRSMILRSRTKTQEIFHSKRRRPSEGRLPNCRATKKLLDNSHLPATFKVSSSPQKEGRVSQRARVPKPGAGSKLSDRPLHALKRKSAFMAPVPTKKRNLVLRSRSSSSSNASGNGGDGKEERPEGSPTLFKRMSSPKKAKPTKGNGEPATKLPPPETPDACLKLASRAAFQGAMKTKVLPPRKGRGLKLEAIVQKITSPSLKKFACKAPGASPGNPLSPSLSDKDRGLKGAGGSPVGVEEGLVNVGTGQKLPTSGADPLCRNPTNRSLKGKLMNSKKLSSTDCFKTEAFTSPEALQPGGTALAPKKRSRKGRAGAHGLSKGPLEKRPYLGPALLLTPRDRASGTQGASEDNSGGGGKKPKMEELGLASQPPEGRPCQPQTRAQKQPGHTNYSSYSKRKRLTRGRAKNTTSSPCKGRAKRRRQQQVLPLDPAEPEIRLKYISSCKRLRSDSRTPAFSPFVRVEKRDAFTTICTVVNSPGDAPKPHRKPSSSASSSSSSSSFSLDAAGASLATLPGGSILQPRPSLPLSSTMHLGPVVSKALSTSCLVCCLCQNPANFKDLGDLCGPYYPEHCLPKKKPKLKEKVRPEGTCEEASLPLERTLKGPECAAAATAGKPPRPDGPADPAKQGPLRTSARGLSRRLQSCYCCDGREDGGEEAAPADKGRKHECSKEAPAEPGGEAQEHWVHEACAVWTGGVYLVAGKLFGLQEAMKVAVDMMCSSCQEAGATIGCCHKGCLHTYHYPCASDAGCIFIEENFSLKCPKHKRLP

Rai1

Retinoic acid-induced protein 1

1889 amino acids

Transcriptional regulator of the circadian clock components: CLOCK, ARNTL/BMAL1, ARNTL2/BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation.

201.571 kDa

MQSFRERCGFHGKQQNYPQTSQETSRLENYRQPGQAGLSCDRQRLLAKDYYSPQPYTGYEGGTGTPSGTVATAAADKYHRGSKSLQGRPAFPSYVQDSSPYPGRYSGEEGLQTWGGPQPPPPQPQPLPGAVSKYEENLMKKTVVPPPNRQYPEQGPQLPFRTHSLHVPPPQPQQPLAYPKLQRQKPQNDLASPLPFPQGSHFPQHSQSFPTSSTYAPTVQGGGQGAHSYKSCTAPSAQPHDRPMSANANLAPGQRVQNLHAYQPGRLGYEQQQQALQGRHHTQETLHYQNLAKYQHYGQQGQGYCPPDTAVRTPEQYYQTFSPSSSHSPARSVGRSPSYSSTPSPLMPNLENFPYSQQPLSTGAFPTGITDHSHFMPLLNPSPTDAASSVDPQAGNCKPLQKEKLPDNLLSDLSLQSLTALTSQVENISNTVQQLLLSKATMPQKKGVKNLVSRTPEQHKSQHCSPEGSGYSAEPAGTPLSEPPSSTPQSTHAEPQDTDYLSGSEDPLERSFLYCSQARGSPARVNSNSKAKPESVSTCSVTSPDDMSTKSDDSFQSLHSTLPLDSFSKFVAGERDCPRLLLSALAQEDLASEILGLQEAIVEKADKAWAEASSLPKDNGKPPFSLENHGACLDTVAKTSWSQPGEPETLPEPLQLDKGGSTKDFSPGLFEDPSVAFATTDPKKTSSPLSFGTKPLLGTATPDPTTAAFDCFPDTPTASSVDGANPFAWPEENLGDACPRWGLHPGELTKGLEQGAKASDGVGKADAHEASACMGFQEDHAIGKPAAALSGDFKQQEAEGVKEEVGGLLQCPEVAKANQWLEESRHCCSSTDFGDLPLLPPPGRKEDLEAEEEYSSLCELLGSPEQRPSLQDPLSPKAPLMCTKEEAEEALDTKAGWVSPCHLSGEPAVLLGPSVGAQSKVQSWFESSLSHMKPGEEGPEMERAPGSSGTSQGSLAPKPNKPAVPEGPIAKKEPVPRGKSLRSRRVHRGLPEAEDSPCRVPALPKDLLLPESCTGPPQGQAEGAGAPGRGLSEGLPRMCTRSLTALSEPQTPGPPGLTTTPTPPDKLGGKQRAAFKSGKRVGKPSPKAASSPSNPAALPVASDSSPMGSKTKEPDSPSMPGKDQRSMVLRSRTKPQQVFHAKRRRPSESRIPDCRATKKLPANNHLPTAYKVSSGPQKEGRMNQRVKVPKPGTGNKLSDRPLHTLKRKSAFMAPVPAKKRSLILRSNNGSGGDGREERAESSPGLLRRMASPQRARPRGSGEPPPPPPLEPPAACMGLSTQSSLPSAVRTKVLPPRKGRGLKLEAIVQKITSPGLKKLACRVAGAPPGTPRSPALPERRPGGSPAGAEEGLGGMGQMLPAASGADPLCRNPASRSLKGKLLNSKKLSSAADCPKAEAFMSPETLPSLGTARAPKKRSRKGRTGTLGPSKGPLEKRPCPGQPLLLAPHDRASSTQGGGEDNSSGGGKKPKTEELGPASQPPEGRPCQPQTRAQKQPGQASYSSYSKRKRLSRGRGKTAHASPCKGRATRRRQQQVLPLDPAEPEIRLKYISSCKRLRADSRTPAFSPFVRVEKRDAYTTICTVVNSPGDEPKPHWKPSSSAASSSTSSSSLEPAGASLTTFPGGSVLQQRPSLPLSSTMHLGPVVSKALSTSCLVCCLCQNPANFKDLGDLCGPYYPEHCLPKKKPKLKEKARLEGTLEEASLPLERTLKGLECSASTTAAAPTTATITTPTALGRLSRPDGPADPAKQGPLRTSARGLSRRLQSCYCCDGQGDGGEEVAQADKSRKHECSKEAPTEPGGDTQEHWVHEACAVWTSGVYLVAGKLFGLQEAMKVAVDMPCTSCHEPGATISCSYKGCIHTYHYPCANDTGCTFIEENFTLKCPKHKRLPL

RAI1

Decapping nuclease RAI1

507 amino acids

Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping and pyrophosphohydrolase activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity).

Belongs to the DXO/Dom3Z family.

57.549 kDa

MPDKRALSDSYEQLPLKRAATVSSNTNDISDERIIATLRHPRACVSASGSPFSASPSFQQPVPLCSFSFDEHRKQWHDDRCKRFYRGPPPYNQRHPRQHGARAVFGADLNYGLERFVRRDQDVPEHLDALVAALQHRTEAAVSDEERDQVDQERRKADVVTWRGIITKICTAYEQTAEARFSDPLELNAMMLDDTLYLEEYTCKSARAQKQNKEDDPKMLRMGYYGYSFESYCTVDTELQTREPFRPIPSKESSLPHPAGWSGDVNTNVQWCQVVKTKLGNNRLVIGGEVDAVERNPKTGREELVELKTSMQMTWAQHNPSKAALDQERFEKKLLKFFLQSYLLGIGKIVVGFRDHHGILTTHQDFETLRIPRMVRAGQPIAGRFDHTGKPVIRQQSVWEPKDGLGFGDQILSFIRQTILSRSIQATPTEQISAGAGANTPNPTAAVGQVHHPVYRVTFRSPFDQVEMRCLSEQEIYEEVQDSGGSGARVGFLPRSFYDFVQRRAGS

rai1

Decapping nuclease rai1

412 amino acids

Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping and pyrophosphohydrolase activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity).

Belongs to the DXO/Dom3Z family.

47.743 kDa

MITRQVLILGHWNSRFRAFIHIHSAGQPLFSTMTAAFPIQPVARFAGKSELVKRPKEFACFSYDADHKFLLGAQSLKWYYTPDLNVDLSKGFESFIKHDDSVDEHLDSLLTTIADYEQKTSKPIDAHIVTWRGMMTKIMAAPFDDDDGFEMNATLYRGCIFIEENHAYKQASRANERPWNGPIPQEVMQYWGYKFETLSTLPKPWGQTSRDFIESRPDHVVNNKEQYCSVVRTGIGKTILCIGGEVDAIWDDKPRTQGDPINWVELKTSAVIQNERQANNFERKLMKFWIQSFLLGVPKIIVGFRTQDGLLVETKEFRTMEIPLMVKKNGRPKWDGDTCVNFANGFLEWLRHTITDEGVWRIKRRPRSAEIEVFKVEEVGHGDIITDEFMNWRIKLELRQAQPPTEDNETEE

RAI1

Decapping nuclease RAI1

400 amino acids

Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping and pyrophosphohydrolase activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity).

Belongs to the DXO/Dom3Z family.

46.191 kDa

MGISANLFVNQKGTTTALKQPKEIGYYSRNQTEEYLVSDDINLRYYYLPDQEIEHGIDLSAGASKFRDVAKDFKDRCSLKGLLDTLMEYEKKKNKKSNVDIITFRGIMSKLIRASMEPPNFNKVDLRIVSYDGQLFIKDVSDYNAATNESNSSGVNSRQQAGTSRQQIDTYTGYKFEGIATLDKPLPYVEREVIEKRPRKILNNGDEYITVVRTGVGECKVVLGAEIDCIFDFKEEGKDNLKHYTELKCSSQISTTNDVRRFEKKMFRAWLQCFLVGVPRVIYGFRDDQYMLKTVEEFSTEEIPVIIKANNPTLGQSCLDAIKWYGLFTDWLLKIIPREQSGNIRAYRLVYENNHLRLSEIEEQDGEYSRYVLEDGILTPEFKEWRESLRVPSEETPKAD

RAI1

Decapping nuclease RAI1

391 amino acids

Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping and pyrophosphohydrolase activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity).

Belongs to the DXO/Dom3Z family.

45.689 kDa

MAKSLPLNSRSKTTALKQPRELFSYARDIDGKYVYDDPENSLSYYYLPDSTIDTGIDLQGGYSKFKKIPDEQNLADFNSLLKAIIKYETSEGKKISSDIITFREIMTKILSLPYNLTDPIDLYVVPFDGQLFIKSDDELDMKRRKEQEVRMKQTNTVERYDYMKRCEYVGYKFETIATIPKPWSQVSRSQIENRNKKVVNNYEQYLSVIRTGIGNVKLVLAGEIDCCWDYLPDEQNKKLNHYVELKTSRIIENNSQVVSFEQKLFKAWCQCFLMGVTKIIYGFRDNNLILKNVELFNTEEIPILIKNNPLTNAATEKKINCTNALKWYGAVVDWLNTTVDKKDETKSYRLKYDPVRKSFTLSETESETNEKLRNGELLTPEFTEWRQSLKK

RAI1

Decapping nuclease RAI1

387 amino acids

Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping and pyrophosphohydrolase activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates. Stimulates exoribonuclease activity of RAT1, allowing it to degrade RNAs with stable secondary structure more effectively. Required for the processing of nuclear mRNA and rRNA precursors. May promote termination of transcription by RNA polymerase II.

Belongs to the DXO/Dom3Z family.

44.51 kDa

MGVSANLFVKQRGSTTALKQPKEIGFYSRTKDEEYLISDDTNLNYYYLPDAELDRKLDLSSGFQKFKDYYKDFEDRCSLRGLLETIESSERHKGKKINADIITFRGIARKLISCAFDSPSFNTVDLRIVSFNGQLFIKEVPEAVNAAKASSATEAGRNINQDLNVFTGYKFETLATLSNPLQYTPREVIEKRTKRIVSHGDEYISVVRTGVGNCKLILGAEVDCIFDFKENGRDNLKHYAELKCTQQVANISDTHKFERKLFRTWLQCFLVGIPRIIYGFKDDHYVLKTVEEFSTEEVPVLLKNNNPQVGSACLEAIKWYGLLTEWLLKMIPRDEDPHSQIRAFKLVFENNHLRLSEIEESDEEYSGLIDGEHILSNGFKEWRKSLK

RAI1

Decapping nuclease RAI1

386 amino acids

Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping and pyrophosphohydrolase activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity).

Belongs to the DXO/Dom3Z family.

43.474 kDa

MPHSIPLLRPNPADPVPSYRLPHLIHTYSHLPTRAISHDDASMAYYSLAPIGCNLTEGFERRIEREDEEEHLDGLVESLEWLITRGRKGERKGGIITWRGMLTRLITMPYETRDPWEMTAIALDGSVYLELWDPPEEKAKRKREQSAWEKQGYMGYAYESFSTIPQEGRPGNGPEGWGGDVNTNVQWANVVRSAIGEIPLCIAGEVDCVKAEPGSPNPGLSGCMELKTNKVIQHPGHEAMFHKKLLKHWAQSWLLGIPEVVVGFRDDDGILRSQTTFDTAKIPYLVEVLNKPSWSPNRCLQSLHSVCSFLTKNVLPTDPLVTYPHIRGNRQAVKEAGELPPAVVWRLAFDPKKGCELHAVGEVGVVDGRWGGMLKEEYVRWRMGLE

RAI1

Decapping nuclease RAI1

386 amino acids

Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping and pyrophosphohydrolase activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity).

Belongs to the DXO/Dom3Z family.

43.544 kDa

MPYSIPLLRPNPADPVPFYRLPHLIHTYSHLPTRAISHDDASMAYYSPAPIGCNLTEGFERRIEREDEEEHLDGLVESLEWLITRGRKGERKGGIITWRGMLTRLITMPYETRDPWEMTAIALDGSVYLELWDPPEEKAKRKREQSAWEKQGYMGYAYESFSTIPQEGRPGNGPEGWGGDVNTNVQWANVVRSAIGEIPLCIAGEVDCVKAEPGSPNPGLSGCMELKTNKVIQHPGHEAMFHKKLLKHWAQSWLLGIPEVVVGFRDDDGILRSQTTFDTAKIPYLVEVLNKPSWSPNRCLQSLHSVCSFLTKNVLPTDPLVTYPHIRGNRQAVKEAGELPPAVVWRLAFDPKKGCELHAVGEVGVVDGRWGGMLKEEYVRWRMGLE

RAI1

Decapping nuclease RAI1

385 amino acids

Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping and pyrophosphohydrolase activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity).

Belongs to the DXO/Dom3Z family.

44.597 kDa

MIKTFPLNSRAKTTALKQPKELFSFARDIDGEYIFDSTKVQDENLSYYYLPDASVDKQIDLGAGYSNFKKIPEEENLGDFPALLKGVMNYEQSTGTKINSDIITFRGLMTKILTLPYNLKDPLDLHVIVYDGQLFIKNNDEIELKRRQQNNQHEDPSKQEMMKKFEYSGYKFEAVSTLPKPWGDCSRQLIEKRNKKVVNNYEQYISVVKTGIGKVKLLLAGEVDCLWDYIPEDGKDILPHYVELKTSKVIEAPGQVVNFEKKLFRTWAQSFLIGIRKIVYGFRDDNLILRNVEVYNTEEIPIMLKDTINVNTKIVCMNALKWYGAVIEWINNEIPKDADKSWSLTYDPGSKSFSIVELMQDSELRNSVITEDFKEWRISLHKTES

RAI1

Decapping nuclease RAI1

384 amino acids

Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping and pyrophosphohydrolase activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity).

Belongs to the DXO/Dom3Z family.

44.509 kDa

MVLSSSLFVQKRSTTTALKQPKELGHYSRTQDNGFLVNDDSRLAYYYLPDTDLDKKLDLLSGIKKFKECNTEEFDSTTLHGLLSTLEEYERRKSKKTKVDIITFRGIIRKLISSAFDSSQFNPVNFRIVSFDGQLFIKEVKTDASETSINKNRESLQARAYYSGYKFEALATLSLPLPLVPRTTLEKRPKKIINNGDQFISMVRTGIGKCKILIGAEVDCIFDFKEDSDDNLKHYAELKCTTMVNTVSDAHKFERKLFKTWLQCFLVGINRIIYGFRDDNFMLKTVEEFTTSEVPLILKNNNPQMQTVCVDAIKWYGAFTEWLLTSIPRPEDDIDTIKAYKLIFENNHLKLTEIESDDEEYKQLVEGEEILSNSFKQWRKDLRK

RAI1

Decapping nuclease RAI1

376 amino acids

Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping and pyrophosphohydrolase activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity).

Belongs to the DXO/Dom3Z family.

42.939 kDa

MAARFSIQPIGRFAGESQPVKRPKEFACFSYDDNHEFRLDGSSLKYYYTPQLGADLSKGFDTFQKLDDTGDDHLDSLLKTIVAHEQETGKKIDANVVTWRGMMTKIMATPFDNMDGFEMNATLYQVCPSFIEENNAYKVASRSNEGNNNRRRRGPPLEVMQFWGYKFETLSTLPAPWAETPREFIENRENEVVNNKAQYCSVVRTGIGKSVLCLGGEVDAIWDSKPEEKGSPINWVELKTSAEIRNTGDMENFNRKLMKYWIQSFLLGVPRIVVGFRTRDGILVEAKDIETHRIPETVNSYPNPKWNADMCVNFAATFLDWLSANITDEGVWRIKREPQSPTIELFKVEETGHGDILSDEFKNWRIKLALGPSNES

RAI1

Decapping nuclease RAI1

373 amino acids

Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping and pyrophosphohydrolase activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity).

Belongs to the DXO/Dom3Z family.

42.668 kDa

MTLQFPIQAPARYAGETEPVKRPREFACFSYDKDHKFRLDDSSMKWYYPPEIGTNLSHGYDTFIKHDDSVDEHLDSLLKTIADHEQQTGGPIDAHIVTWRGMLTKVGGSDASFLSLWFEMNATLYRLTFTSGYKFETLSTIPRPWGETTRDYIENRDNEVTNNKEQYCSVVRTGFGKSIVCLGGEVDAIWDAKPETPGKPINWVELKTTAEIHTHNDRFKFDRKLMRYWIQSFLLGVPKIIVGYRTQDGILSGVEEFSTLSMPQDVQRRKTAKWDGNVCIKFASLFLDWLRQSINDGGVWRIRRENKSDHIELFKVEEVGHGSIITDEFMNWRIKLSLNKDKPPGFEPSDAADAEPSMAEEPVPETASASGAY

rai1

Decapping nuclease rai1

365 amino acids

Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping and pyrophosphohydrolase activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity).

Belongs to the DXO/Dom3Z family.

42.031 kDa

MDGGTFDIQPIGRFYGSNTTIRRPREITCFSYDAEHKFHLGDSSLRYYYTPRLPADLNRGFDTFQKLDDTADEHLDALLETIMALEKETGKRCEADIITWRGMMTKILTAPFDNLNGFEMNATCFQVGGENNLYKIQQKQIQENQRMPPGMASQDLMAYWGYKFETLCLLQQPWDPTPRAEIESREDLVVNNNAQYCSVVRTGIGSTRLIIGGEVDAVWDCKPDRKEDPINWVELKTSAEIRNDRDMIKYERKLLKFWAQSFLLGVPKIIVGFRDNHGIVHRLEELETASIPNKVKKLGRGTWDGNICINFAAAFLEWLKSTIKEGGTWRIRKLEKSSLIQVFKIEETGTGDIISRSFLDWRSRS

rai1

Decapping nuclease rai1

357 amino acids

Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping and pyrophosphohydrolase activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity).

Belongs to the DXO/Dom3Z family.

41.065 kDa

MNRETFDIQPIGRFYGSNTAIRRPREIACFSYDDQHKFHLGDSSLRYYYPPQLPADLNRGFDTFQKLDDAADEHIDALLDTIAAMEKETGKRCEADIITWRGMMTKILTAPFDDMNGFEMNATCFQGTMCKQLQRQQRMPPGMASQDLMAYWGYKFETISVLDKTWDEASREEIEGRENLVVNNNAQYCSVVRTGIGRTKLVLGGEVDAIWDSKPERKEDPINWVELKTSAEIRKDWDMVKFERKLLKFWAQSFLLGVPKIVVGFRDQGGILRRLEELETANIPNRVRKSGRGTWDGNICINFAATFLEWLKSVIKEGGTWRLRKAEKSSVIEVYQVEESGTGDILSQAFLSWRSTT

RAI1

Decapping nuclease RAI1

349 amino acids

Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping and pyrophosphohydrolase activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity).

Belongs to the DXO/Dom3Z family.

40.314 kDa

MSSFSTTERLAAKLKKPKEVYSYSITDGKVTMDQSQLKYYYLPEETILKAPIDLTKGIENWTQPNEHDTHLDTLLESLSKYERETGSKIDAEIITWRGILTKIMTHPYDQYNEPIVLNITYFDGHYFIEEDWQSKQQGKKAPDEQMKKHIYSGYKFESVALLNEPWFKSSREDIESRFDDIPNGDQFVSVVRTQIGDNKILIGGEVDCVFDPCAKGTSRYGELKTSREVHNAKDGEILERKMNRAWAQSFLLGVKHIIYGYRTGDHKLAAVDYFKTEDLPMYAGASSTWSGTDEINFLNAALTKLKDLPKEDNKLWRLVFDSANKKVDITELDGESFLLKEFVDWRKSM