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RAD17

Gene
Rad17
Protein
Cell cycle checkpoint protein RAD17
Organism
Mus musculus
Length
688 amino acids
Function
Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination (By similarity). Essential for embryonic development. May be involved in homologous recombination.
Similarity
Belongs to the rad17/RAD24 family.
Mass
77.391 kDa
Sequence
MSETFLRPKVSSTKVTDWVAPAFDDFEANTAITTITASSLTFSNSSHRRKYLPSTLESNRLSARKRGRLSLEQTHGLETSRERLSDNEPWVDKYKPETQHELAVHKKKIEEVETWLKAQVLEVKPKQGGSVLLITGPPGCGKTTTIKILSKELGIQVQEWVNPILPDFQKDDYKELLSLESNFSVVPYQSQIAVFNDFLLRATKYSKLQMLGDDLTTDKKIILVEELPNQFYRDPNALHEILRKHVQIGRCPLVFIVSDSVSGDNNQRLLFPRNIQEECSVSNISFNPVAPTIMMKFLNRIVTIEASKNGEKIIVPNKTSLELLCQGCSGDIRSAINSLQFSSSKGENSSWSKKKRMSLKSDAAISKSKQKKKHNSTLENQEIQAIGGKDVSLFLFRALGKILYCKRAPLTELDSPRLPAHLSEHDRDTLLVQPEEIVEMSHMPGDFFNLYLHQNYIDFFAEVDDLVPASEFLSFADILGGDWNTRSLLREYSTSVATRGVMHSNKARGFAHCQGGSSFRPLHKPQWFLIQKKYRENCLAAKALFVDFCLPALCLQTQLLPYLALLTIPMRNKAQISFIQDVGRLPLKRSFGRLKMEALTDRELGLIDPDSGDESPHSGGQPAQEAPGEPAQAAQNADPETWSLPLSQNSGSDLPASQPQPFSSKVDMEEEEEEEEDIIIEDYDSEET

Gene
RAD17
Protein
Cell cycle checkpoint protein RAD17
Organism
Homo sapiens
Length
681 amino acids
Function
Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination.
Similarity
Belongs to the rad17/RAD24 family.
Mass
77.055 kDa
Sequence
MSKTFLRPKVSSTKVTDWVDPSFDDFLECSGVSTITATSLGVNNSSHRRKNGPSTLESSRFPARKRGNLSSLEQIYGLENSKEYLSENEPWVDKYKPETQHELAVHKKKIEEVETWLKAQVLERQPKQGGSILLITGPPGCGKTTTLKILSKEHGIQVQEWINPVLPDFQKDDFKGMFNTESSFHMFPYQSQIAVFKEFLLRATKYNKLQMLGDDLRTDKKIILVEDLPNQFYRDSHTLHEVLRKYVRIGRCPLIFIISDSLSGDNNQRLLFPKEIQEECSISNISFNPVAPTIMMKFLNRIVTIEANKNGGKITVPDKTSLELLCQGCSGDIRSAINSLQFSSSKGENNLRPRKKGMSLKSDAVLSKSKRRKKPDRVFENQEVQAIGGKDVSLFLFRALGKILYCKRASLTELDSPRLPSHLSEYERDTLLVEPEEVVEMSHMPGDLFNLYLHQNYIDFFMEIDDIVRASEFLSFADILSGDWNTRSLLREYSTSIATRGVMHSNKARGYAHCQGGGSSFRPLHKPQWFLINKKYRENCLAAKALFPDFCLPALCLQTQLLPYLALLTIPMRNQAQISFIQDIGRLPLKRHFGRLKMEALTDREHGMIDPDSGDEAQLNGGHSAEESLGEPTQATVPETWSLPLSQNSASELPASQPQPFSAQGDMEENIIIEDYESDGT

Gene
RAD17
Protein
Cell cycle checkpoint protein RAD17
Organism
Pongo abelii
Length
681 amino acids
Function
Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination (By similarity).
Similarity
Belongs to the rad17/RAD24 family.
Mass
77.232 kDa
Sequence
MSKTFLRPKVSSTKVTDWVDPSFDDFLECRDVSTITATSLGVNNSSHRRKNGPSTLESSRFPARKRGNLSSLEQIYGLENSKEYLSENEPWVDKYKPETQHELAVHKKKIEEVETWLKAQVLERQPKQGGSILLITGPPGCGKTTTIKILSKEHGIQVQEWINPVLPDFQKDDFKGMFNTESSFHMFPYQSQIAVFKEFLLRATKYNKLQMLGDDLRTDKKIILVEDLPNQFYRDSHTLHEVLRKYVRIGRCPLIFIISDSLSGDNNQRLLFPKEIQEECSISNISFNPVAPTIMMKFLNRIVTIEANKNGGKITVPDKTSLELLCQGCSGDIRSAINSLQFSSSKGENNLWPRKKGMSLKSDAVLSKSKQRKKPDRVFENQEVQAIGGKDVSLFLFRALGKILYCKRASLTELDSPRLPSHLSEYERDTLLVEPEEVVEMSHMPGDLFNLYLHQNYIDFFMEIDDIVRASEFLSFADILSGDWNTRSLLREYSTSIATRGVMHSNKARGYAHCQGGGSSFRPLHKPQWFLINKKYRENYLAAKALFPDFCLPALCLQTQLLPYLALLTIPMRNQAQISFIQDIGRLPLKRHFGRLKMEALTDREHGMIDPDSGDEAQLNGGHSAEESLGEPTQATALETWSLPLSQNSASELPASQPQPFSAQGDMEENIIIEDYESDGT

Gene
RAD17
Protein
Cell cycle checkpoint protein RAD17
Organism
Chlorocebus aethiops
Length
670 amino acids
Function
Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination (By similarity).
Similarity
Belongs to the rad17/RAD24 family.
Mass
76.066 kDa
Sequence
MNQVTDWVDPSFDDFLECRDISTITATSLGVNNSSHRRKNGPSTLESSKFPVRKRGNLSSLEQIYSLENSKESLSENEPWVDKYKPETQHELAVHKKKIEEVETWLKAQVLERQPKQGGSILLITGPPGCGKTTTIKVLSKEHGIQVQEWINPVLPDFQKDDFREIFNTESSFHMFPYQSQIAVFKEFLLRATKYNKLQMLGDDLRTDKKIILVEDLPNQFYRDSHTLHEVLRKYVRIGRCPLIFVISDSLSGDNNQRLLFPKEIQEECSISNISFNPVAPTIMMKFLNRIVTIEANKNGGKITVPDKTSLELLCQGCSGDIRSAINSLQFSSSKGENNLWPRKKGMSLKSDAVLSKSKRRKKPDRVFENQEVQAIGGKDVSLFLFRALGKILYCKRASLTELDSPRLPSHLSEYERDTLLVEPEEVVEMSHMPGDLFNLYLHQNYIDFFMDIDDIVRASEFLSFADILSGDWNTCSLLREYSTSIATRGVIHSNKARGYAHCQGGGSSFRPLHKPQWFLIYKKYRENCLAAKALFPDFCLPALCLQTQLLPYLALLTIPMRNQAQISFIQDIGRLPLKRHFGRLKMEALTDREHGMIDPDSGDEAQLNGRHSTEESLGEPTQASAPETWSLPLSQNSASELPASQPQPFSAQGDMEENIIIEDYESDGT

Gene
rad17
Protein
Checkpoint protein rad17
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
606 amino acids
Function
Participates in checkpoint pathways arrest of the cell cycle. A mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes.
Similarity
Belongs to the rad17/RAD24 family.
Mass
68.882 kDa
Sequence
MRRQLSFHESTKRSLKKKKIRKIEKPSLVSKTSRDKNASITDIHEEDIEAFSDEENKIVHLNNLKEDRFQLWFEKYIPQKAADLAVHKSKISAIKQWMLTDSLESRLLLICGPSGCGKSTAVQVLAKELGYSLIEWLNPMNLKEPSNQESDTLSLTEKFSRFMSLCETYPELELMDSNNIQKRGKNAQGKKKFIFLDEIPHLSKFNGSLDAFRNVIRTALTSRGAFSIIMVLTEIQLNNLEGINSQDRNSFNSVQIMGNDLLQDPRVTVLQFNPIAPTYMKKCLGSILRKEGVPKSPKLLSLVENICSASEGDLRSAINSLQLSISQSFEKKGTKNIREVKEGKGKGNDFSLEAAQVLERLSKSDSEAYARFKNYKSAYIPKSDKNENSFFKKDVGLGMMHAIGKVVWNKREGDDEVLKASSQQTGNSERIKGVKVSKSQENKNCISLKSDQRERMLNVDQCFTSKRRSLVDIESTINQSGLSGSVFRYGLFENYVDSCVTTDEAFNVCDLLSISDCLSHDFPYSYTGDEISTWFSVQGTLFYLPSPVPRKWRQLRFQQWNNEGIVRGIFDDYMVIYGKRSVSDPVIEAHEDQVLEDIDDPIEDED

Gene
RAD17
Protein
Cell cycle checkpoint protein RAD17
Organism
Arabidopsis thaliana
Length
599 amino acids
Function
Seems to be involved in regulation of DNA repair correlated to non-homologous double strand breaks (DSBs) repair. In vitro, involved in rapid but not in slow DSB repair mechanism. Required for effective immune responses that involve activation of DNA damage responses (PubMed:24207055).
Similarity
Belongs to the rad17/RAD24 family.
Mass
66.819 kDa
Sequence
MLKKKLSLEDEDDDRSYNLRSSRSNAKSKPRSSAGTATNPRASKRARLSGASATQEDSSLVDKIRLSFEDFDEALSGFKVSSGYERSKNTDLWVDKYRPRTLEELSVHKKKVDEVKLWFQESLDFLKNGLRNNVLLVTGQAGVGKSATIHLITSILGVTVHEWNAPIPTIWQEHVHNTSSGLKYTSKLDEFENFVESTRKYGVMASSSTDGIKAPVVLLIDDLPLANGRHAFERLQNCLLLLVKSTQIPTVILITDHNNADSSDQTARRMEDTQSSLERAGALKVAFNPITKNSIKKVLQRICREEHCKVTTMEIDQMATASGGDIRHAITSLQLFSVKPELNHTKIKSPRPGMEDNYHGNEQTMYSGLDSGISSCFGRDETLSLFHALGKFLHNKRETDNVIISECSSSLVHDEFARLPLKMDAPEKVLSQAHGQAGRVVDFLHENVLDFVSDGAIEDAWCVSSYLADADLLLADIRGKMSGHNNTEDVPQSAGASVAVRGVLYGNKQPCSSRWHVIRKPKLWQVEQSSIQTKKNLREQRNISYEGSRVADISVMATEYSPVLKWLSYRASPDAFPGMGEETDEEDSDISEDDEIQDW

Gene
RAD17
Protein
DNA damage checkpoint control protein RAD17
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
401 amino acids
Function
Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes. Associates with sites of DNA damage and modulates the MEC1 signaling pathway and the activation of RAD53 in response to DNA damage at phase G1. The complex also physically regulates DNA polymerase zeta-dependent mutagenesis by controlling the access of polymerase zeta to damaged DNA. Contrary to its human counterpart, the 9-1-1 complex, the checkpoint clamp complex shows no detectable exonuclease activity.
Similarity
Belongs to the rad1 family.
Mass
45.58 kDa
Sequence
MRINSELANKFSASTVHLEHITTALSCLTPFGSKDDVLIFIDADGLSFVRENNHVIKIQLLLSRELFMSYSYRNETEDHMKLCVKINHILDSVSVMNRNSDDIVECTLSYDGHGSPFVLIFEDSFISERVEYSTYLIKDFDTNGLELDRERISFEAIIKGEALHSALKDLKEIGCKECYVYAKTEANDENVFALISKSQLGFSKIKLPSNRSILEKLQVFDGDSTTVIDGFAVIGFFDFTSFDKIRKSTKIASKVLFRMDVHGVLSVNILSQTDDVIITDTTRPSNNRPGSIRQLQLPKDYPGIVIEVCMLEKESIDEAAQTEIELLMETNELGNRNSFKKSTIRKRYGTDKGNETSNDNLLQLNGKKIKLPSEEENNKNRESEDEENHCKYPTKDIPIFF

Gene
RAD17
Protein
DNA damage checkpoint control protein RAD17
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
389 amino acids
Function
Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes.
Similarity
Belongs to the rad1 family.
Mass
43.153 kDa
Sequence
MLESTALFSATTIHLDRLMCAFNCMTPFGQRDDVLITIDRDGLTFIRQNNHAAEIQLFLAKELFQYYSIREGFEGEIQLCMKLNHLLDTVSVANRDKDDVVECTLSYDGEGTPFMLILEDSMITEQVEYATYLVGEMDRTGLELDRARLEFECILKGDVLYSALRDLREIGCKECYLYIVTSSRARPMFALVSRGQLGLSKIILPSERSVLEKLEVYENDSTTLIHDAPVIGLFDFAALDKLRPSTKIASKVLIRKDVHGLLAVNILSDTNAILVPEKRELIRASRSVSAEYPTVVIEVFLLEKASVGDIDVRDVHQLMLTSPAHRRSGFADSGSRIVSVTPTATSAAHTGAGSLLGLAPPSAFPAEETQDPDESYHPAPSNTDIPLFL