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Pret-172

Gene
Pret-172
Protein
Protein DP71L
Organism
African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996)
Length
71 amino acids
Function
Interacts with the host phosphatase PP1 catalytic subunit (PPP1CB) and recruits it to dephosphorylate EIF2S1/eIF2alpha and therefore restores the host translation that has been shut-down by the host. Also inhibits the EIF2S1/eIF2alpha-ATF4-DDIT3/CHOP pathway.
Similarity
Belongs to the asfivirus DP71L family.
Mass
8.418 kDa
Sequence
MGGRRRKKRTNDVKHVRFAAAVEVWEADDIERKGPWEQAAVDRFRFQRRIASVEELLSAVLLRQKKLLEQQ