Protein
2-phosphinomethylmalate synthase
Organism
Streptomyces hygroscopicus
Function
Involved in the biosynthesis of the herbicide bialaphos (BA). Catalyzes the condensation berween phosphinopyruvic acid (PPA), an analog of oxalacetic acid, and acetyl-CoA to form R-2-phosphinomethylmalic acid (PMM) (PubMed:3781934, PubMed:3170341). Can also act on oxaloacetate, but shows no activity when acetyl-CoA is substituted by propionyl-CoA or butyryl-CoA (PubMed:3170341).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family.
Sequence
MTVQNPQEPEYFPEVFPQDAFPQYAWDEGMRPITLPHEVWLSETTHRDGQQGGLPLSLDTSRRIYDILCEITGDSTAIRHAEFFPYRDSDRNALIYALERHRDGAPIEPTTWIRARREDVELIKRIGVIETGLLSSSSDYHTFHKFGSGGRTQAASMYLDAVTMALDHGIRPRVHLEDTTRSSPDFVRALVEEVLKTAERYPAELQPRFRVCDTLGIGLPYDDVSLPRSIPRWIRLLRGFGLSPSQIELHPHNDTWLVVANCLAAIREGCGVISGTTLGTGERTGNAPLEAVMVHLLGMGYWSGARVNLPAVNKLVELYEGIGAGPSQKYPFFGRDAYVTRAGIHADGLNKFWWMYAPFNAPLLTGRELDVALTKDSGQAGLLFVLNKRLGLQLEKGDPRVAEVLAWMDRQWDAGRVSAVEWSELEPVVEKAFATEEGVG