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Pacs2

Gene
PACS2
Protein
Phosphofurin acidic cluster sorting protein 2
Organism
Homo sapiens
Length
889 amino acids
Function
Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.
Similarity
Belongs to the PACS family.
Mass
97.702 kDa
Sequence
MAERGRLGLPGAPGALNTPVPMNLFATWEVDGSSPSCVPRLCSLTLKKLVVFKELEKELISVVIAVKMQGSKRILRSHEIVLPPSGQVETDLALTFSLQYPHFLKREGNKLQIMLQRRKRYKNRTILGYKTLAAGSISMAEVMQHPSEGGQVLSLCSSIKEAPVKAAEIWIASLSSQPIDHEDSTMQAGPKAKSTDNYSEEEYESFSSEQEASDDAVQGQDLDEDDFDVGKPKKQRRSIVRTTSMTRQQNFKQKVVALLRRFKVSDEVLDSEQDPAEHIPEAEEDLDLLYDTLDMEHPSDSGPDMEDDDSVLSTPKPKLRPYFEGLSHSSSQTEIGSIHSARSHKEPPSPADVPEKTRSLGGRQPSDSVSDTVALGVPGPREHPGQPEDSPEAEASTLDVFTERLPPSGRITKTESLVIPSTRSEGKQAGRRGRSTSLKERQAARPQNERANSLDNERCPDARSQLQIPRKTVYDQLNHILISDDQLPENIILVNTSDWQGQFLSDVLQRHTLPVVCTCSPADVQAAFSTIVSRIQRYCNCNSQPPTPVKIAVAGAQHYLSAILRLFVEQLSHKTPDWLGYMRFLVIPLGSHPVARYLGSVDYRYNNFFQDLAWRDLFNKLEAQSAVQDTPDIVSRITQYIAGANCAHQLPIAEAMLTYKQKSPDEESSQKFIPFVGVVKVGIVEPSSATSGDSDDAAPSGSGTLSSTPPSASPAAKEASPTPPSSPSVSGGLSSPSQGVGAELMGLQVDYWTAAQPADRKRDAEKKDLPVTKNTLKCTFRSLQVSRLPSSGEAAATPTMSMTVVTKEKNKKVMFLPKKAKDKDVESKSQCIEGISRLICTARQQQNMLRVLIDGVECSDVKFFQLAAQWSSHVKHFPICIFGHSKATF

Gene
Pacs2
Protein
Phosphofurin acidic cluster sorting protein 2
Organism
Mus musculus
Length
862 amino acids
Function
Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments (By similarity).
Similarity
Belongs to the PACS family.
Mass
94.932 kDa
Sequence
MAERGRLGLPGAPGALNTPVPMNLFATWEVDGSSPSCVPRLCSLTLKKLAVLRELEKELLSVVIAVKMQYPHFLKREGNKLQIMLQRRKRYKNRTILGYKTLAAGSINMAEVMQHPSEGGQVLSLCSSIKEASVKVAEIWIVSLSSQPIDHEDSAMQAGPKTKSTDNYSEEEYESFSSEQEASDDAVQGQDLDEDDFDVGKPKKQRRSIVRTTSMTRQQNFKQKVVALLRRFKVSEEVLDSEQDPAEHVPEVEEDLDLLYDTLDVENPSDSGPDMDDDDSVLSTPKPKLRPYFEGLSHSSSQTEIGSIHSARSHREPPSPADVPEKTRSLGGKQQLSDSVSDTVALSAAVPREPSGQPEDSPEAETSTLDVFTEKLPPSGRIIKTESLVIPSTRSESKPAGRRGRSTSLKERQPARPQNERANSLDNERCPDTRSQLQIPRKTVYDQLNHILISDDQLPENIILVNTSDWQGQFLSDVLQKHTLPVVCTCSAADVQAAFSTIVSRIQRYCNCNSQPPTPVKIAVAGAQHYLSAILRLFVEQLSHKTPDWLGYMRFLIIPLGSHPVARYLGSVDYRYNNFFQDLAWRDLFNKLEAQSSVQDTPDIVSRITQYISGANCAHQLPIAEAMLTYKQKSPDEESSQRFIPFVGVVKVGIVEPSSATSGDSDDAAPSSSSILSSTPPSASTSPAAKEASPTPPSSPSVSGGLSSPSQGVGAELMGLQVDYWTAAQPADRKRDAEKKDMPTTKNTLKCTFRSLQVSRLPSSGEAAATPTMSMTVVTKEKNKKVMFLPKKTKDKEVESKSQCIEGISRLICTAKHQQNMLRVLIDGVECSDVKFFQLAAQWSSHVKHFPICIFGHSKATF