About Products Protein Database Contact

PYR1

Gene
pyr1
Protein
Pyruvate carboxylase
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
1185 amino acids
Function
Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
Mass
130.861 kDa
Sequence
MTSKYDALLHNQSTNTNPFSKLQDRSSLLGEKFTKVLVANRSEIAIRVFRTAHELSMHTVAIYSYEDRLSMHRQKADESYPIGKVGQYSPVGAYLAIDEIVSIAKRTGANLVHPGYGFLSENAEFARKVNEAGMQFVGPSPEVIDSLGDKTKARAIAIRCGVPVVPGTPGPVEHYEEAEAFVKEYGLPVIIKAAMGGGGRGMRVVRSADTLKESFERARSEALASFGDGTVFIERFLDKPKHIEIQLMADKAGNVIHLHERDCSVQRRHQKVVEIAPAKDLDPKIRQALYDDAIKIAKEVKYCNAGTAEFLLDQKGRHYFIEINPRIQVEHTITEEITGVDIVSAQLHVAAGFTLPEIGLTQDKISTRGFAIQCRVTTEDPNNGFAPDIGKIEVYRSAGGNGVRLDGANGFAGSVITPHYDSMLVKCTCHDATYEYTRRKMIRSLIEFRVRGVKTNIPFVLRLLMHDTFIQGNCWTTFIDDTPELFQLYRSRNRAQKLLAYLGDLAVNGSSIKGQNGEPALKSEIVMPVLLDSTGNQIDVSHPSEKGWRKLLLDNGPAAFAKAVRNHKRGLIMDTTWRDAHQSLLATRVRTIDLVNIAPYTSHALASAYSLEMWGGATFDVSMRFLHECPWDRLRRLRKLVPNIPFQMLLRGANGLCYSSLPDNVIYFFCEQAKKNGIDIFRVFDALNDVNNLSLGIDAAKRAGGVVEATMCYSGDMLNPKKKYNLDYYVNLVDKMVEMGIHILGIKDMAGVMKPKAARLLISAIREKHPELPIHVHTHDSAGTAVASMAAALEAGADVVDVATDSMSGLTSQPSFGAVLASVDGTDKQLEFDNNQLREIDSYWAQMRLLYSPFESEIKGTDSDVYNHEIPGGQLTNLKFQATSLGLGTQWAETKKAYIEANKLLGDIIKVTPTSKVVGDLAQFMVQNKLSAEDVENRATTLDFPASVLDFFQGLMGQPYGGFPEPLRTNVLKGRRQPLTDRPGKFLPAADFDAIRKLLSEKFGVSSDCDIAAYTQFPGVFEEYRQFVDRYGDLTTVPTKFFLSRPEMNEEMHVEIDQGKTLIVKFVALGPLNPRTGQREVYFELNGENRHVTVEDKKAAIETVTRPRADPGNPGHVAAPMSGTIVEIRVKEGAKVKKGDIIAVLSAMKMEIVISAPHSGVLKSLAVVQGDSVNGGDLCAVLEHE

Gene
pyr1
Protein
Nicotinic acid-CoA ligase pyr1
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
Length
581 amino acids
Function
Nicotinic acid-CoA ligase; part of the gene cluster that mediates the biosynthesis of pyripyropene A, a specific human acyl-coenzyme A:cholesterol acyltransferase 2 inhibitor (PubMed:20861902). The first step of the pathway is the synthesis of nicotinyl-CoA from nicotinic acid by the nicotinic acid-CoA ligase pyr1 (PubMed:20861902). Nicotinyl-CoA is then a substrate of polyketide synthase pyr2 to produce 4-hydroxy-6-(3-pyridinyl)-2H-pyran-2-one (HPPO) which is further prenylated by the polyprenyl transferase pyr6 to yield farnesyl-HPPO (PubMed:20861902). The next steps consist of an epoxidation of farnesyl-HPPO to epoxyfarnesyl-HPPO by FAD-dependent monooxygenase pyr5 and a cyclization of the terpenoid portion by the terpene cyclase pyr4 to yield deacetyl-pyripyropene E (PubMed:20861902). The 2 cytochrome P450 monooxygenases pyr3 and pyr9, and the 2 acetyltransferases pyr7 and pyr8 are involved in the conversion of deacetyl-pyripyropene E into pyripyropene A through several cycles of oxidation and acetylation steps (PubMed:20861902). Pyr7 acetylates deacetyl-pyripyropene E to pyripyropene E which is oxidized to 11-deacetyl-pyripyropene O by pyr3, which is in turn acetylated into pyripyropene O by pyr8 (PubMed:21224862, PubMed:26019565). Pyripyropene O is then oxidized to deacetyl-pyripyropene A by pyr9 (PubMed:21224862). Deacetyl-pyripyropene A is finally acetylated to pyripyropene A by pyr8 (PubMed:26019565).
Similarity
Belongs to the ATP-dependent AMP-binding enzyme family.
Mass
63.501 kDa
Sequence
MEPHGETDLVSFAFSSPTPFDPTRPIYLDAQNPSRAFNARQFRLLVRSLIAGLRALGLKPGHCVLVQLENTVIHSALFFAIVGAGGVYMGCDVGSPAHELTHLLRLAEPQLVITAPGALSTLEVCSTQGESFSGQVLLVDELSIDNIVQFAHRAAAAGAEAQTEGLVDQTAGPCIRLESLLQHGESDWLRFEDREQSKRTPAAMFLTSGTSGLPKAAISTHHTIISHHLSVHYRVPYPVVRLMALPMYHSFGDFWTNIFPIRYGEPLYVLPRFDISTFLDAVRQHHISETYMVPAMVQILSQSSLPVAESLASLRYVGISGAPIDGFSIQRFQRLLSPDAVAGNLWGMTEVGVVFQNRYRVPLQFGSVGTLLHGYELRFVDPATGEDVAGTPDSPGELYVRGPGLLLGYKWRTDDKDEQGWFRTGDMVYARDGNYYIIGRTKDLIKVRGQVPDSLNSWTSHSTNRLCDSRYSVAPAEIEGILLKDPGVKDAAVIGVMLPDGSSEVPRAYVVRAGISPESTADQLTDLVQTQLASYKALDGGVVFVDEIPRTGIGKPHRARLSQLDREREKLASILGVSVPA

Gene
PYR1
Protein
Orotidine 5'-phosphate decarboxylase
Organism
Passalora fulva
Length
278 amino acids
Similarity
Belongs to the OMP decarboxylase family.
Mass
29.957 kDa
Sequence
MSSKSQLPFSTRASNHPNPLARKLFEVAEAKKSNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFGPETINGLNALAEKHNFLIFEDRKFIDIGNTVQKQYHGGALKISEWAHIINCAVLPAEGIVQALAETAQAEDFPHGSERGLLILAEMTSKGSLATGEYTSASVDYARKYPSFVLGFVSTRALTEVSSTVTAADNEDFVVFTTGVNLSSKGDKLGQQYQTPQSAIGRGADFIIAGRGIYTAPDPVEAAKQYQQQGWEAYLARVGGASQ

Gene
PYR1
Protein
Orotate phosphoribosyltransferase
Organism
Colletotrichum graminicola
Length
233 amino acids
Function
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
Similarity
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Mass
25.232 kDa
Sequence
MASQLPPYKQDFLKAAIAGVLKFGSFELKSKRISPYFFNAGDFYRADLLRAISLAYAHTVIEAREATGLDFDVVFGPAYKGIPLATSTTDKLAELDPARYGTTCYSFDRKEAKDHGEGGNIVGAPLKGQKVLIVDDVITAGTAKREAIAKIRKEGGEVVGIVVALDRMEKLPAADGDDSKPGPSALGEIKKEYGIPIFSILTLDDIIEGAKSFASAEDIKRTEEYRAKYKATD

Gene
PYR1
Protein
Abscisic acid receptor PYR1
Organism
Arabidopsis thaliana
Length
191 amino acids
Function
Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA (PubMed:19407142, PubMed:19624469, PubMed:19769575, PubMed:23844015, PubMed:21658606). Can be activated by both (-)-ABA and (+)-ABA (PubMed:23844015). Promotes drought tolerance (PubMed:29970817).
Similarity
Belongs to the PYR/PYL/RCAR abscisic acid intracellular receptor family.
Mass
21.575 kDa
Sequence
MPSELTPEERSELKNSIAEFHTYQLDPGSCSSLHAQRIHAPPELVWSIVRRFDKPQTYKHFIKSCSVEQNFEMRVGCTRDVIVISGLPANTSTERLDILDDERRVTGFSIIGGEHRLTNYKSVTTVHRFEKENRIWTVVLESYVVDMPEGNSEDDTRMFADTVVKLNLQKLATVAEAMARNSGDGSGSQVT