PUL1

Probable cyclodipeptide synthase PUL1

480 amino acids

Probable cyclodipeptide synthase; part of the PUL gene cluster that mediates the formation of pulcherrimin, a red iron-containing pigment composed of two cyclized and modified leucine molecules that acts as a siderophore, a chelator that binds iron outside the cell for subsequent uptake (PubMed:30297402). Two leucine molecules are cyclized via a cyclodipeptide synthase, and the resulting diketopiperazine is oxidized by a cytochrome P450 monooxygenase to generate pulcherriminic acid (PA), which can then spontaneously bind iron to form pulcherrimin (PubMed:30297402). The probable cyclodipeptide synthase PUL1 and the cytochrome P450 monooxygenase PUL2 encode the enzymes responsible for the two-step pulcherrimin biosynthesis pathway (Probable).

55.417 kDa

MYQLLFQRLGVTLTAGNDKKTSIPSNQLVGHLIGLILLCDDLNEAFADFQALLQNGIAISSSDRGYLVFDAHVTDCGCHLRAQMIQDVFSYFKNHEVTKLYIFDAVAKKLNELKRHCISLIQTLCWENTSAQKLGFPKNIKSYEELLKLLQWDTADISSAIADSFPMNPNNADQNEKGLVWNVTKLEVVLEFLYCSHFLSKNKIYNKKENLDSVTIDFNNAFEKRQLLSNKFHCQGTGKLGVGCRYLKHAKQSKNSFISVVSNLQSRLALLSIAFLKSRCTLPCDIEALQKNSPRNVSAIPNFLHFLILEREWSQNETPILLAVRKLHEHEHCDLYFEARINPHTFEWTLQHKECCEFEHHTPYIVITALATGSSTTKTAQLLAWELMKAQKNFRQFWLTFMSQHRQYPFEIEHDEDQLLETQVSQDIFELYCQSKREDRNQILFDDSTSLLPKHIFTEYPSIFFNFQKNVCSKHGALVI