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PTR1

Gene
ptr1
Protein
E3 ubiquitin-protein ligase ptr1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
3227 amino acids
Function
Probable ubiquitin ligase protein involved in mRNA export. E3 ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. Probably participates in mRNA export from the nucleus by regulating the transport of hnRNP proteins such as rae1.
Similarity
Belongs to the UPL family. TOM1/PTR1 subfamily.
Mass
365.035 kDa
Sequence
MRITKSPPKNQYSQPPPRVAEFIRQAQNEEVTSDLGLVSLCSEFRKNDWPYPRGDLYSWVPVLNRFDAILERIVEHYSLKDKVQTKPFDSDTLSILLEILSFSAHLLSHCANRSIYNSTVYLEYLLNSSVLEVIDSTLALLLHIVQKATISKRGKQLFSLSQDRLFRFLMFLPQDAMKTGFSQNYETLLFSNEIPQEWCSLELSYYKSSPSKDFSSASQPNSEGFSILKLPYNKVLGKPIEELLVKTLHDNQIPEQYSFDLLVSLMLRQNLYDINRRRLMIRIGLLALSNLVYAHSQAVQTRFLIADPEITTHLANLVSPDVDLPQNFKAVCFECFKAFFFKKSMIPSVLASLNVSVSYGLMMNLVRDFSKNLENPNFYYEREYVDSFYDFLQFMTSSPLGGNMACSAGLTSLLGYHLSVKTPQATYVVARSIVMLDHLIDGYSMAFPDFSESKGLDMLVDRVQYELEAGLQDIKSGKGNPEIVLNMDYAISYDRYFLLKNLLKFVLHLIQSGGSVVELRNLIDSSLISSLAFLLEHHEVYGSNLFASTTNIMSTFIHNEPTCYGIIHEKKLSHAFLDAVNRKILNSSDAITSIPLAFGAICLNSQGFDLFLEKNPIPQLFSIFTSLNHCKSLISSDNAAILGTYIDELMRHQPSLKDPIVKMIFKACDQVSALLDNFNPFQYINAKEYPYLLYLETFSSFLENIITNEGHARYLISKGIVSHVLNLIQHPVLAFGFIDSSAFNSFFVLLHHAVDFDAPEVFRPLLDCIITRCEEGITEFTIVSLKQATISLIKDSNMGHEDANNFLHFSIVGNLLTIFAELFSSHAALKKAGNLPLVQLFISPSRYAGIFDILCNIKSIATSLDIHICLGVSDDFVLCSDSLTTIVTDKDEKEKFETKKKELTQDSSFCKFQNIRSNFSQIAYGVSKFFTSLTRALGNTSVQDFNEYKMIHKLGSNIALVVDELINLSSKQITSHPQSLSIASLEASLIFVLGASSIIREDDSKVTLVLLISRLLGGCRTMDVLISLNETVSGFFRLSDRDPLSKSNRVLLALSSTLLNLILVFTSADFMSETSKTLNMALKSEFDMTDFNNSGSKLMHVLHARIFISVLHLWRSADDLHLPYITRALLTNVLSNCYQFEDGIKNVVDSINNLRTSIANGDIKEPLDVVTDDNTNSNFSLEETNASVTDMPESEKHENGIFQAYLLKEMPNDIVSQFEMLKSKQIELTVQMASYEGDLNQNLCDFLYTRDDVQMNADVQFSVTSGLIVEIKKLAQSTDCKAKNQLGPAVGLLSLFISHDFTQNKAKNCVLSELNFFLELLHSLNNGLPSDSHKTSIVCILYLLEVLLADSKKPDEFEFNSEDCSLKLTDGAITVDLASQKHIMSSVITLLSLNSANLGVVVSAFRVVVLLTSASEMIHTFVKLSGLPSLFKAMRACSGFCNESLHIPFISILRRLLEFDEVVELMMFDDLVNIFKLQGRARKTELHGFIRANAEMVLRSPECFIKILKDCCVLGHFTPESEHYYLELKESLPGVLQNGQTDLDPSKEQMSSVIVSFLLDELMDLTETRQFSDRSPNSEFTPENDSLYMYNVFLLQCLTELLSGYNACKRCFLNFQPRRKAPFFNLSRKYNSYLVGFFLEKLLPFGCIRLSENNEVRKAFSVSNWAISILVFLCAYSNEQQTQAVDEIRREVLTSVLKFYKSSSSFSENLEAYYCKLLVLAELCYRLCDAQTVSQKAPNHLLRRSQDQNVKTMIDLGYIPTLTNAISEIDMNYPVSRKVVRHILKPLQLLTKEAIFLSQTNPEALSGAAQDSMGDQSLSSSSEESSDSDREEPPDLYRNSVLGIFQGDIVNENDENYEDSEDDGVYEEMEFEDDQSGSADSVVSEDDADDVMYSDNDDMNIEFMVDEQDASSQNDDSSFDEASSHGDVISIDEEDLDNQGEEFEWEDEDNASSGYEDELDYNEDEVGENDSTTFEAMENAFTETSDNDDHLEEADHVSPVEIDFLENDENSSSEQDDEFQWEWNTETPSGADILSRHGALLRDLFPLPGLSRRVMIINSNDPSRSRPFLNNNASEGLLKHPLLLRNNLIHTPKATELWENLAEIDNHTASGAAFQRLLYYLALEIPNEDSSVLGWTSLKVSKHTDPLRATSDFIPLFSMQRWNSITSMFFAHASGSIALRITGSVLFALVPPALEKYNLENQKKEILENESKEEETRQPEVNIQPEEPINTSDMEGVTTEANEIGSYQEPSLINIRGREVDVSSLGIDPTFLLALPEEMREEVVFQHIQERHMESISDSSRRIDPSFLEVLPSDLRDELLFQEAVQMRLFDHATRNNNSVDHEVEMEEIDQGGTVSEHREKSVKPVKKIPVPNLLDRQGLYSLIRLIFISQHNGKNPYYDLIVNISENKQHRADIVGLLLYILQEASINDRASEKCYRDLTVKSLNNSQQKEVKKSTGLLESLCKVPVVNGISAPALILQQGIDLLSHLATWADHFASFFLSMHDFSGIASKKSAGRKNRESNVYKIAPINVLLGLLAREELFGNTLVMNTFSELLSTLTKPLLSFYKSEKLQKDSATTGYTNDQDSRGSTVPKQDPGTTASRKDKKILSPPNILDENLRLAASLITTDSCSSRTFQNALSVMFHLSSIPKAKILIGKELLRHGQEYGNSITNDLSRLCADVKSGKNESELQVALAPFCPASSNQAKLLRCLKALDYIFERRPKGQEQSPGNIIQLLEFYDNLKFSSLWEVLSECLSALRDHTSITHVSTVLLPLIESLMVICRLVFIELPEDVGKHISPILERFKTLFISFTEEHRKIINMMVFTTPSLMSGSFSLLVKNPKVLEFENKRNYFNRQLHEEAAKEQYPPLNITVRRDHVFLDSYRALHFKDADEVKFSKLNIHFRDEEGVDAGGVTREWLQVLARQMFNPDYALFLPVTGDATTFHPNRDSSVNPDHLSFFKFTGRIIGKALYDGRLLDCHFSRAVYKHMLHRSVSVKDIESLDPDYYKSLVWMLNNDITDIITEEFAVEKDVFGEKTVVDLIPNGRNIPVTELNKQNYVNRMVDYKLRESVKDQLKSLLDGFSDIIPSHLIQIFNEQELELLISGLPEIDIDDWKNNTEYHGYNVSSPQVQWFWRAVRSFDEEERAKLLQFATGTSKVPLNGFKELEGMSGFQRFNIHKSYGSLNRLPQSHTCFNQLDLPEYDTYEQLRSMLLTAINEGSEGFGFA

Gene
PTR1
Protein
Pteridine reductase 1
Organism
Leishmania tarentolae
Length
289 amino acids
Function
Exhibits a NADPH-dependent biopterin reductase activity. Has good activity with folate and significant activity with dihydrofolate and dihydrobiopterin, but not with quinonoid dihydrobiopterin. Confers resistance to methotrexate (MTX).
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Mass
30.744 kDa
Sequence
MTTSPTAPVALVTGAAKRLGSSIAEALHAEGYTVCLHYHRSAADASTLAATLNARRPNSAITVQADLSNVATASFSETDGSVPVTLFSRCSALVDACYMHWGRCDVLVNNASSFYPTPLLRKDAGEGGSSVGDKESLEVAAADLFGSNAIAPYFLIKAFAQRVADTRAEQRGTSYSIVNMVDAMTSQPLLGYTMYTMAKEALEGLTRSAALELASLQIRVNGVSPGLSVLPDDMPFSVQEDYRRKVPLYQRNSSAEEVSDVVIFLCSPKAKYITGTCIKVDGGYSLTRA

Gene
PTR1
Protein
Pteridine reductase 1
Organism
Leishmania major
Length
288 amino acids
Function
Exhibits a NADPH-dependent biopterin reductase activity. Has good activity with folate and significant activity with dihydrofolate and dihydrobiopterin, but not with quinonoid dihydrobiopterin. Confers resistance to methotrexate (MTX).
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Mass
30.457 kDa
Sequence
MTAPTVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLSNVATAPVSGADGSAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLRNDEDGHEPCVGDREAMETATADLFGSNAIAPYFLIKAFAHRFAGTPAKHRGTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMPPAVWEGHRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA

Gene
ptr1
Protein
HTH-type transcriptional regulator Ptr1
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
Length
148 amino acids
Function
Participates in positive as well as negative regulation of transcription. Binds to its own promoter.
Mass
16.633 kDa
Sequence
MLDRIDLKILRILNGNARKSFREIGRELGISEGTVRNRVKRLTEKGIITGFHASINPKNLGFEVVAILGLYIKPSKVEETLNKLKELDEIVELYQTTGEYDAVCIAILKDIESLGKFLAEKIYPLVNVNGCKVTLVLRTFKDGSKMPI