PSTK

Gene

Pstk

Protein

L-seryl-tRNA(Sec) kinase

Organism

Mus musculus

Length

359 amino acids

Function

Specifically phosphorylates seryl-tRNA(Sec) to O-phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis. No activity with other tRNAs has been detected.

Similarity

Belongs to the L-seryl-tRNA(Sec) kinase family.

Mass

40.763 kDa

Sequence

MKTAAARGATRRDGQPKLGLCVLCGLPAAGKSTFARALALRLRRERGWAVGVLSYDDVLPLALPDCDGTQPRPSQWKMFRQELLKHLECFLVAVISGAQMSAPPNRTEAVWEDFITCLKSQDLMIFPTALEAQPCHLLAKPAVSRPLFLVLDDNFYYQSMRYEVYQLARKYSLGFCQLFLDCPLETCLKRNGERSQPLPDETIQLMGRKIEKPNPEKNAWEHNSLIIQSSACSLEASLEVTGLLLTALENPIKCVEDNTEQKETDRIICSTNILHKADETLRRTVSQTMREAKDEQIPLNNLKHLAEELNKLKADVLEDLRQGNRKYLCFQQTTDLSDIISSFCKERDTIVQKYFSKQH

Protein

L-seryl-tRNA(Sec) kinase: Pstk

Gene

PSTK

Protein

L-seryl-tRNA(Sec) kinase

Organism

Homo sapiens

Length

348 amino acids

Function

Specifically phosphorylates seryl-tRNA(Sec) to O-phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis.

Similarity

Belongs to the L-seryl-tRNA(Sec) kinase family.

Mass

39.527 kDa

Sequence

MKTAENIRGTGSDGPRKRGLCVLCGLPAAGKSTFARALAHRLQQEQGWAIGVVAYDDVMPDAFLAGARARPAPSQWKLLRQELLKYLEYFLMAVINGCQMSVPPNRTEAMWEDFITCLKDQDLIFSAAFEAQSCYLLTKTAVSRPLFLVLDDNFYYQSMRYEVYQLARKYSLGFCQLFLDCPLETCLQRNGQRPQALPPETIHLMGRKLEKPNPEKNAWEHNSLTIPSPACASEASLEVTDLLLTALENPVKYAEDNMEQKDTDRIICSTNILHKTDQTLRRIVSQTMKEAKGNQEAFSEMTFKQRWVRANHAAIWRIILGNEHIKCRSAKVGWLQCCRIEKRPLSTG

Protein

L-seryl-tRNA(Sec) kinase: PSTK

Gene

pstK

Protein

L-seryl-tRNA(Sec) kinase

Organism

Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)

Length

255 amino acids

Function

Specifically phosphorylates seryl-tRNA(Sec) to O-phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis.

Similarity

Belongs to the L-seryl-tRNA(Sec) kinase family.

Mass

29.79 kDa

Sequence

MRLLILTGPPGSGKTCFARELARELRQEGWRVAHVEADALRGFLWDEFDPKLEQVARELFLKSVETCLDAELDLVIADDTNYYSSMRRELALLALERKVPWGIVYLRTGLDTCLRRNRERGEPIPEEVVRRIYDRFEPPEPDRWWERATLVLDDSRVSEEVLEFVESGLRVEKPKKRRRRTDPSSVNEVDVRTRQVMGELMRRLSETGAATQELGRKLSELRREIVSSVEDPEKAVREFRRRAEEVIRECLHGDG

Protein

L-seryl-tRNA(Sec) kinase: pstK

Gene

pstK

Protein

L-seryl-tRNA(Sec) kinase

Organism

Methanococcus maripaludis (strain S2 / LL)

Length

255 amino acids

Function

Specifically phosphorylates seryl-tRNA(Sec) to O-phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis.

Similarity

Belongs to the L-seryl-tRNA(Sec) kinase family.

Mass

29.776 kDa

Sequence

MLIILTGLPSVGKSTFSKAFSKKMAEKNIDNIILGTDLIRESFPVWKESYEEFIRDSNNYLIKEALENKFSVIVDDTNYYNSKRRDLMNIAKECDTNYVTIYLKAPLNLLLKRNIERGQKIPNEVIKNMYEKFDTPGTKYAWDLPDITVDTTEKIDYNEILNEILEINENKNLKIEEDKIPKSEPVESDLVKIDSLTRNIVGNLIKTGKIDKKDIKLLSEIRKSFLKDCKKIESEKLDFEKIEKDFLDYLNKNLK

Protein

L-seryl-tRNA(Sec) kinase: pstK

Gene

pstK

Protein

L-seryl-tRNA(Sec) kinase

Organism

Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

Length

248 amino acids

Function

Specifically phosphorylates seryl-tRNA(Sec) to O-phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis.

Similarity

Belongs to the L-seryl-tRNA(Sec) kinase family.

Mass

29.467 kDa

Sequence

MLIILTGLPGVGKSTFSKNLAKILSKNNIDVIVLGSDLIRESFPVWKEKYEEFIKKSTYRLIDSALKNYWVIVDDTNYYNSMRRDLINIAKKYNKNYAIIYLKASLDVLIRRNIERGEKIPNEVIKKMYEKFDEPGKKYKWDEPFLIIDTTKDIDFNEIAKKLIEKSKEIPKFYVLEENKNKNNNISDKIDKETRKIVSEYIKSKKLDKDKIKEVVELRKEFLKKIKKMEEVDADRVLKEFKDLLNSY

Protein

L-seryl-tRNA(Sec) kinase: pstK