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PRR5

Gene
prr5
Protein
Proline-rich protein 5
Organism
Xenopus laevis
Length
400 amino acids
Function
Subunit of TORC2, which regulates cell growth and survival in response to hormonal signals.
Similarity
Belongs to the PROTOR family.
Mass
44.563 kDa
Sequence
MRSKFMSSPTLSDLGKREATAAAALDERGTQQKRAGANATWNSIQNGVISVFQKKGLADHELYSLNEGVRQLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDILPMLQAIFYPVQGKEPSIRQLALLHFRNIITLNLKLDDALSRPRARVPPSIIQMLLILQGVHESKGVTEEYMNLESLIQKVVSPYLGTYGLYSNEAPFCHSSCILEKRMFRRCPKSGEILTKNPVVRSKSYNNPLLTPVAEYEMENLVANGSGIRRHSVSEMTSVLELPMGYSNLTTDSTSKLSMAGTKPPGEGERPPISNGQFPPLHNLSDSQQGLYNSQRDSPLLPAPSSSPETIVDQILESIDSDSEGIFIDFGRGCSKSPEFSMEIGRQSLV

Gene
PRR5
Protein
Proline-rich protein 5
Organism
Homo sapiens
Length
388 amino acids
Function
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer.
Similarity
Belongs to the PROTOR family.
Mass
42.753 kDa
Sequence
MRTLRRLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHNGVIAVFQRKGLPDQELFSLNEGVRQLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKLEDALARAHARVPPAIVQMLLVLQGVHESRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRSKSYNTPLLNPVQEHEAEGAAAGGTSIRRHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPRSSPENLVDQILESVDSDSEGIFIDFGRGRGSGMSDLEGSGGRQSVV

Gene
Prr5
Protein
Proline-rich protein 5
Organism
Mus musculus
Length
387 amino acids
Function
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer (By similarity).
Similarity
Belongs to the PROTOR family.
Mass
42.523 kDa
Sequence
MRTLRRLKFMSSPSLSDLGKREPGAAGTDERGTQQRRACANATWNSIHNGVIAVFQRKGLPDQELFILNEGVRQLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPTLQAIFYPVQGKEPSVRQLALLHFRNTITLSVKLEDALARSHARVPPAIAQMLLVLQGVHESRGVTEDYLRLETLIQKVVSPYLGTYGLYSNEGPCTHSCILEKRFLRRSRSGDILAKNPVVRSKSYNTPLLNPVAEHEAEGTAASGTSIRRHSVSEMTSCPEPQGFVDTPGQGPSGTFRSSPTPHSGPCPSRLYPPAHSPEQGPGHGSPSTSSPETLVDQILESADSDSEGIFIDFGRGSRSSVSDFEAPGGRPSVV

Gene
Prr5
Protein
Proline-rich protein 5
Organism
Rattus norvegicus
Length
387 amino acids
Function
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-421'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer (By similarity).
Similarity
Belongs to the PROTOR family.
Mass
42.54 kDa
Sequence
MRTLRRLKFMSSPSLSDLGKREPGAAGADERGTQQRRACANATWNSIHNGVIAVFQRKGLPDQELFILNEGVRQLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPTLQAIFYPVQGKEPSVRQLALLHFRNTITLSVKLEDALARSHACVPPAIAQMLLVLQGVHESRGVTEDYLRLETLIQKVVSPYLGTYGLYSNEGPCTHSCILEKRFLRRSRSGDILAKNPVVRSKSYNTPLLNPVAEHEAEGTASGGTSIRRHSVSEMTSCPEPQGFVDTPDQGPSGTFRSSPSPHSGPCPSRLYPPAHSPEQGPDHGSPPTSSPETLVDQILESVDSDSEGIFIDFGRGSRSSVSDFEAAGGRPSVV