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PRP38

Gene
PRP38
Protein
Pre-mRNA-splicing factor 38
Organism
Arabidopsis thaliana
Length
355 amino acids
Function
Probably required for the first pre-mRNA cleavage reaction catalyzed by the spliceosome.
Similarity
Belongs to the PRP38 family.
Mass
43.172 kDa
Sequence
MANRTDPLAKNIRGTNPQNLVEKIVRTKIYQHTFWKEQCFGLTAETLVDKAMELDHLGGTFGGSRKPTPFLCLILKMLQIQPEKEIVVEFIKNDDYKYVRILGAFYLRLTGTDVDVYRYLEPLYNDYRKVRQKLSDGKFSLTHVDEVIEELLTKDYSCDIAMPRLKKRWTLEQNGLLEPRKSVLEDDFEEEEEKEENEGIADGSEDEMDQRRKSPERERERDRDRRRDSHRHRDRDYDRDYDMDRDHDRDYERERGHGRDRDRERDRDHYRERDRDRERGRDRERDRRDRARRRSRSRSRDRKRHETDDVRDREEPKKKKEKKEKMKEDGTDHPNPEIAEMNRLRASLGMKPLRD

Gene
Prp38
Protein
Pre-mRNA-splicing factor 38
Organism
Drosophila melanogaster
Length
330 amino acids
Function
Required for pre-mRNA splicing.
Similarity
Belongs to the PRP38 family.
Mass
40.088 kDa
Sequence
MANRTVKEAKNVHGTNPQYLIEKIIRSRIYDSKYWKEQCFALTAELLVDKAMELRFVGGVYGGNIKPTQFLCLTLKMLQIQPEKDIVVEFIKNEEFKYVRALGAFYLRLTGAALDCYKYLEPLYIDNRKLRRQNRAGQFEIVYMDEYIDELLRNDRVCDIILPRIQKRSILEENNEIEPKVSVLDEDLDDELPSDEEKADETNRPKENSTAVRRPRRVRSKSRSRSRERERRSGQGNSARSRDYYDELEDYDRQRNRVRNRDTHNEDYDRRQNNGRHDRERERQDRDSIRERERDGDRDRRDRERERERDRGRHDQRERDSRGERDRRRY

Gene
PRP38
Protein
Pre-mRNA-splicing factor 38
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
242 amino acids
Function
Required for pre-mRNA splicing and maintenance of stable U6 small nuclear RNA levels. Implicated in the formation of stable and biologically active snRNP structures. As part of the U4/U6.U5 tri-snRNP particle, dispensible for spliceosome assembly, but required for conformational changes, which result in U4 snRNA release and the subsequent catalytic activation of the spliceosome.
Similarity
Belongs to the PRP38 family.
Mass
27.967 kDa
Sequence
MAVNEFQVESNISPKQLNNQSVSLVIPRLTRDKIHNSMYYKVNLSNESLRGNTMVELLKVMIGAFGTIKGQNGHLHMMVLGGIEFKCILMKLIEIRPNFQQLNFLLNVKNENGFDSKYIIALLLVYARLQYYYLNGNNKNDDDENDLIKLFKVQLYKYSQHYFKLKSFPLQVDCFAHSYNEELCIIHIDELVDWLATQDHIWGIPLGKCQWNKIYNSDEESSSSESESNGDSEDDNDTSSES

Gene
prp38
Protein
Pre-mRNA-splicing factor 38
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
210 amino acids
Function
Required for pre-mRNA splicing and maintenance of stable U6 small nuclear RNA levels. Implicated in the formation of stable and biologically active snRNP structures. As part of the U4/U6.U5 tri-snRNP particle, dispensible for spliceosome assembly, but required for conformational changes, which result in U4 snRNA release and the subsequent catalytic activation of the spliceosome (By similarity).
Similarity
Belongs to the PRP38 family.
Mass
24.462 kDa
Sequence
MADFLARDYRSQGEAAHEMLPTFLIGKILRERIVDSIYWKEQCFGLNACSLVDRAVRLEYIGGQYGNQRPTEFICLLYKLLQIAPEKEIIQQYLSIPEFKYLRALAAFYVRLTWDDVEVHQTLEPLLRDYRKLRIRTNSEIRLTYLDEVVDDLLNAEVVCDISLPPLRSRLQLEDLDLLEPLSSSSDEEDDDEEQISKLESNEGAVDRNI