Protein
4-hydroxyproline 2-epimerase
Organism
Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
Function
Catalyzes the reversible epimerization of cis-4-hydroxy-D-proline (c4DHyp) to trans-4-hydroxy-L-proline (t4LHyp). May be involved in a degradation pathway that allows P.putida strain KT2440 to grow on either epimer of 4-hydroxyproline, c4DHyp and t4LHyp, as the sole carbon and nitrogen source. Does not exhibit measureable racemase activity in vitro with any of the 19 natural chiral amino acid enantiomers.
Similarity
Belongs to the proline racemase family.
Sequence
MKQIHVIDSHTGGEPTRLVMKGFPQLRGRSMAEQRDELRELHDRWRRACLLEPRGNDVLVGALYCPPVSADATCGVIFFNNAGYLNMCGHGTIGLVASLQHMGLITPGVHKIDTPVGQVSATLHEDGAITVANVPSYRYRQQVAVDVPGHGVVRGDIAWGGNWFFLVSEHGQRIELDNREALTEYTWAMLKALETQGVTGENGAPIDHIELFADDPNADSRNFVMCPGKAYDRSPCGTGTSAKLACLAADGKLAEGQTWVQASITGSQFHGRYARDGERIRPFITGRAYMTADSTLLIDEQDPFAWGI