PRODH2

Hydroxyproline dehydrogenase

536 amino acids

Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone-10 as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L-hydroxyproline. Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis.

Belongs to the proline oxidase family.

58.871 kDa

MSPRVVSNSSVLASQSVGITNVRTVFSNVFNNTTAFPILRGSNCHKITAPGLGKGQLVNLLPPENLPWCGGSQGPRMLRTCYVLCSQAGPPSRGWQSLSFDGGAFHLKGTGELTRALLVLRLCAWPPLVTHGLLLQAWSRRLLGSRLSGAFLRASVYGQFVAGETAEEVKGCVQQLRTLSLRPLLAVPTEEEPDSAAKSGEAWYEGNLGAMLRCVDLSRGLLEPPSLAEASLMQLKVTALTSTRLCKELASWVRRPGASLELSPERLAEAMDSGQNLQVSCLNAEQNQHLRASLSRLHRVAQYARAQHVRLLVDAEYTSLNPALSLLVAALAVRWNSPGEGGPWVWNTYQACLKDTFERLGRDAEAAHRAGLAFGVKLVRGAYLDKERAVAQLHGMEDPTQPDYEATSQSYSRCLELMLTHVARHGPMCHLMVASHNEESVRQATKRMWELGIPLDGTVCFGQLLGMCDHVSLALGQAGYVVYKSIPYGSLEEVIPYLIRRAQENRSVLQGARREQELLSQELWRRLLPGCRRIPH

prodh2

Hydroxyproline dehydrogenase

466 amino acids

Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using a quinone as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L-hydroxyproline.

Belongs to the proline oxidase family.

52.329 kDa

MRLLGRYLRLGSPRLCSRVWPTLPPSCSPHSTAAAAQAQGALSFSDGGVFKLKSSWEVARGLLIFRMCSFPSLVKHSEKMLSVSRRLLGRRLFEWGMKGSVYGQFVAGETLPEIRVCVDRLRQLGIHPMLAVPIEEDLGQAKSGERWYEQNESIMLDCVDLSAAGGDRPMMQLKITALMSAELCKLLSVHLSHPSNGPQLCPRSIVSIMEGKESAFSFLSEGENSHLRNSVRRLSRIAKHATANRVRVLVDAEYTYMNPALSLVTMAMMSQCNQSEPWIWNTYQCYLKDSFSLLSLDLDTARSLGLCFGVKLVRGAYMDKERKLSKQKGYADPIQHDWEATNRSYQRSLDKMLDLIGQNGQRHNLIVASHNEESVLHAVTRMAELGIDKGSGSVSFGQLLGMCDHVSLTLGQAGYLVYKSLPYGSVDSVLPYLIRRAQENQSVLQGIRKERDLLRRELKRRLFNQR

PRODH2

Hydroxyproline dehydrogenase

461 amino acids

Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone-10 as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L-hydroxyproline. Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis.

Belongs to the proline oxidase family.

51.262 kDa

MLQACRVLRSRAGPSPGSWQPLSFDGGAFHLKSIGELTRALLVLRLCAWPPLVTHGLALQAWSQRLLGSRLSGALLRASIYGQFVAGETAEEVRSCVLQLQNLGLRPLLAVPTEEEPDSAVKTGEAWYEGNLSAMLRCVDLSRGLLETPDPTGNALMQLKMTALMSTRLCKQLTSWVRRPGDSLELSPERLAEAMDSGQDLQVSCLNTEQTRHLQASLSRLHRVVQHARAQRVRLLVDAEYTSLNPALSLLVAALATRWNSSGEGGPWVWNTYQAYLKDTYERLRWDAEAADRAGLAFGVKLVRGAYLDKERETARLQGTEDPTQPDYEATSQSYSRCLELMLTQVSHRGPMCHLMVASHNEDSVRQATKRMWELGIPPDGPVCFGQLLGMCDHVSLALGQAGYAVYKSIPYGSLEEVIPYLIRRAQENRSVLRGARREQELLSQELRRRLLGRGLRVSPH

Prodh2

Hydroxyproline dehydrogenase

456 amino acids

Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone-10 as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L-hydroxyproline. Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis.

Belongs to the proline oxidase family.

50.723 kDa

MIWTRLPLYGPSKPSTGGWQPLRFDGGAFHVKGTAELARALLVLRLCAWPPLVTHGLAFQAWSQRLLGSRLSGALLRASIYGQFVAGETAEEVRNCVGQLQALGLQPLLAVPTEEEPDSTAKTSEVWYEENLSAMLRCVDLSRALVDAHGPARNSLMQLKVTALASTRLCKELSAWIQRPRGSSELSPERLAEAMDSGRNLQLSCLSTEQNQHLQASLSRLHRVAQHARAKCVRLLVDAEYTFINPALSLLVAALAVRWNSPEEGGPWVWNTYQAYLKDTHQRLEQDAEAAHKAGLAFGVKLVRGAYLDKERSMTQLQGKEDCTQPDYEATSRSYSRCLELMLRCVSNHGPPCHLMVASHNEESVRQATKRMWELGIPLDGPVCFGQLLGMCDHVSLALGQAGYMVYKSIPYGCLEEVIPYLIRRAQENRSVLQGARREQALLSQELWRRLLGRTA

Prodh2

Hydroxyproline dehydrogenase

456 amino acids

Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone-10 as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L-hydroxyproline. Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis.

Belongs to the proline oxidase family.

51.002 kDa

MIWTRLPLYGHSKPSTGGWQPLRFDGGAFHLKRTAELARALLVLRLCAWPPLVTHGLAFQAWSQRLLGSRLSGALLRASIYGQFVAGETAEEVRGCVQQLQAIGLQPLLAVPTEEEPDSAAKTSEAWYEGNLSAMLHCVDLSRAVADAHGPARNSLMQLKVTALTSPRLCKELSAWIQRPRGSSELRPERLAEAMESGRNLQLSCLSTEQNQHLQASLSRLHRVAQHARAQDVRLLVDAEYTFINPALSLLVAALAMRLDSSEEEGPWVWNTYQAYLKDTHERLERDAKAAHEAGLAFGVKLVRGAYLDKERSVTQLHGKEDCTQPDYEATSRSYSRCLELMLRRVSNHGPRCHLMVASHNEESIRQATRRMWELGIPLDGPVCFGQLLGMCDHVSLALGQAGYMVYKSIPYGCLEEVIPYLIRRAQENRSVLQGARREQALLSQELWRRLLGRTA