Protein
DNA-directed primase/polymerase protein
Function
DNA primase and DNA polymerase able to initiate de novo DNA synthesis using dNTPs. Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA. Involved in translesion synthesis via its primase activity by mediating uninterrupted fork progression after programmed or damage-induced fork arrest and by reinitiating DNA synthesis after dNTP depletion. Required for mitochondrial DNA (mtDNA) synthesis, suggesting it may be involved in DNA tolerance during the replication of mitochondrial DNA. Has non-overlapping function with POLH (By similarity).
Similarity
Belongs to the eukaryotic-type primase small subunit family.
Sequence
MKRKWEATLKQIEERASHYERKPLSSVYRPRLSKPEEPPSIWKLFHRQTQAFNFVKSCKQEVHVFALECKVGDGQRIYLVTTYTQLWFYYKSRRNLLHCYEVIPENAVCKLYFDLEFNKLANPGADGKKMVALLIEHVCKALQEFYTVNCSAEDVLNLDSSTEEKFSRHLIFQLHDVAFKDNIHVGNFVRKILQPAFHLIASEDEDMTPETTGHEFTHFSETPSEQGTCFSKMSTDIDVGESQTSNSEKLGRLGSAQQSSPDLSFLIVKNDMGEKRLFVDLGVYTRNRNFRLYKSSKIGKYVALEVAEDNKFFPIQSKNISKENQYFLSSLVSNVRFSDALRILTCDVPQSKQRVQCFSRTGTSVEAIEGFQCSPYPEIDQFVLSLVNKNGIKGGIRRWNYFFPEELLVYDICKYRWCENIGRAHRSNNIMILVDLKNEVWYQKCHDPVCKAENFKSDCFPLPAEVCLLSLLKEGEEFTTDTTADTETKSPHGPSSSVLSKGAFSDADWDNGIDDTYILEATEDAELAEAAENSLLAYNRMDEIPDELLIEVLQE