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PRIMPOL

Gene
PRIMPOL
Protein
DNA-directed primase/polymerase protein
Organism
Homo sapiens
Length
560 amino acids
Function
DNA primase and DNA polymerase able to initiate de novo DNA synthesis using dNTPs. Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA. Involved in translesion synthesis via its primase activity by mediating uninterrupted fork progression after programmed or damage-induced fork arrest and by reinitiating DNA synthesis after dNTP depletion. Required for mitochondrial DNA (mtDNA) synthesis, suggesting it may be involved in DNA tolerance during the replication of mitochondrial DNA. Has non-overlapping function with POLH.
Similarity
Belongs to the eukaryotic-type primase small subunit family.
Mass
64.412 kDa
Sequence
MNRKWEAKLKQIEERASHYERKPLSSVYRPRLSKPEEPPSIWRLFHRQAQAFNFVKSCKEDVHVFALECKVGDGQRIYLVTTYAEFWFYYKSRKNLLHCYEVIPENAVCKLYFDLEFNKPANPGADGKKMVALLIEYVCKALQELYGVNCSAEDVLNLDSSTDEKFSRHLIFQLHDVAFKDNIHVGNFLRKILQPALDLLGSEDDDSAPETTGHGFPHFSEAPARQGFSFNKMFTEKATEESWTSNSKKLERLGSAEQSSPDLSFLVVKNNMGEKHLFVDLGVYTRNRNFRLYKSSKIGKRVALEVTEDNKFFPIQSKDVSDEYQYFLSSLVSNVRFSDTLRILTCEPSQNKQKGVGYFNSIGTSVETIEGFQCSPYPEVDHFVLSLVNKDGIKGGIRRWNYFFPEELLVYDICKYRWCENIGRAHKSNNIMILVDLKNEVWYQKCHDPVCKAENFKSDCFPLPAEVCLLFLFKEEEEFTTDEADETRSNETQNPHKPSPSRLSTGASADAVWDNGIDDAYFLEATEDAELAEAAENSLLSYNSEVDEIPDELIIEVLQE

Gene
PRIMPOL
Protein
DNA-directed primase/polymerase protein
Organism
Bos taurus
Length
555 amino acids
Function
DNA primase and DNA polymerase able to initiate de novo DNA synthesis using dNTPs. Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA. Involved in translesion synthesis via its primase activity by mediating uninterrupted fork progression after programmed or damage-induced fork arrest and by reinitiating DNA synthesis after dNTP depletion. Required for mitochondrial DNA (mtDNA) synthesis, suggesting it may be involved in DNA tolerance during the replication of mitochondrial DNA. Has non-overlapping function with POLH (By similarity).
Similarity
Belongs to the eukaryotic-type primase small subunit family.
Mass
63.721 kDa
Sequence
MKRKWEATLKQIEERASHYERKPLSSVYRPRLSKPEEPPSIWKLFHRQTQAFNFVKSCKQEVHVFALECKVGDGQRIYLVTTYTQLWFYYKSRRNLLHCYEVIPENAVCKLYFDLEFNKLANPGADGKKMVALLIEHVCKALQEFYTVNCSAEDVLNLDSSTEEKFSRHLIFQLHDVAFKDNIHVGNFVRKILQPAFHLIASEDEDMTPETTGHEFTHFSETPSEQGTCFSKMSTDIDVGESQTSNSEKLGRLGSAQQSSPDLSFLIVKNDMGEKRLFVDLGVYTRNRNFRLYKSSKIGKYVALEVAEDNKFFPIQSKNISKENQYFLSSLVSNVRFSDALRILTCDVPQSKQRVQCFSRTGTSVEAIEGFQCSPYPEIDQFVLSLVNKNGIKGGIRRWNYFFPEELLVYDICKYRWCENIGRAHRSNNIMILVDLKNEVWYQKCHDPVCKAENFKSDCFPLPAEVCLLSLLKEGEEFTTDTTADTETKSPHGPSSSVLSKGAFSDADWDNGIDDTYILEATEDAELAEAAENSLLAYNRMDEIPDELLIEVLQE

Gene
Primpol
Protein
DNA-directed primase/polymerase protein
Organism
Mus musculus
Length
537 amino acids
Function
DNA primase and DNA polymerase able to initiate de novo DNA synthesis using dNTPs. Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA. Involved in translesion synthesis via its primase activity by mediating uninterrupted fork progression after programmed or damage-induced fork arrest and by reinitiating DNA synthesis after dNTP depletion. Required for mitochondrial DNA (mtDNA) synthesis, suggesting it may be involved in DNA tolerance during the replication of mitochondrial DNA. Has non-overlapping function with POLH (By similarity).
Similarity
Belongs to the eukaryotic-type primase small subunit family.
Mass
61.33 kDa
Sequence
MLRKWEARVKQIEERASHYERKPLSSVYRPRLAKPEEPSSIWKLFHRQNQAFNFVKSCKESVHVFALECKRGNGQRIYLVTSYAQLWFYYKTRKTLLHCYEVIPENAVCKLYFDLEFNKLANPGADGKMMVALLIQHVCKALEEFYNVQCSAEDVFNLDSSTEEKFSRHLIFQLHNVAFKDNRHAGNFVRKILQPALHLIAEDDEAKVPEAVGQDASGFSVTPLKQEISEAREKVGLPKQCDPDLSFLVVKNHMGEKCLFVDLGVYTKNRNFRLYQSSKIGKCVSLEVAEDNRFIPKQSKDISEENQYFLSSLVSNVRFSDTLRVLTCHPSQTKRKRAECFNSTGTSVESIEGFQGSPYPEVDQFVLSLVNKHDIKGGIRRWNYFFPEELLVYDICKYRWCENIGRAHKSNNIMILVDLKNEVWYQKCHDPVCKAQNFKSTCSPLPTEVSLLFLLKDEDFTSGETDDTSTSLTKDSQTPPSCNLSAGGLSAAAWDDEDDALFLEATEDAEFADAADKSLGSMDDIPDELIIEALQNS

Gene
primpol
Protein
DNA-directed primase/polymerase protein
Organism
Danio rerio
Length
523 amino acids
Function
DNA primase and DNA polymerase able to initiate de novo DNA synthesis using dNTPs. Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA. Involved in translesion synthesis via its primase activity by mediating uninterrupted fork progression after programmed or damage-induced fork arrest and by reinitiating DNA synthesis after dNTP depletion. Required for mitochondrial DNA (mtDNA) synthesis, suggesting it may be involved in DNA tolerance during the replication of mitochondrial DNA. Has non-overlapping function with POLH (By similarity).
Similarity
Belongs to the eukaryotic-type primase small subunit family.
Mass
60.194 kDa
Sequence
MTGGKWQDRVKSVEQRASSFQSSPLSCPYKPRLSQPWQPSSIWRLFPRQNAAIAFAQHIKQDVHIFSLEKEGSDAGQRIFLVTSYSELWHYYSTHRHSLMHCYEVILEGAVCKLYFDLEFHKASNKNLDGKMMVAKLIQYVCEKLEEVYGLHCSAKDVLDLDSSTSDKFSHHLIFMLPNAAFKDNSHVGRFIHDILHPALTNLKKSNPEAPGENRDDVEGTQAKRRKTEENDLGFLTVKNEKGQEQLFVDLGVYTKNRNFRLYKSSKLGKNAAFIVAEDNKFVPNPSKQITKDERIFLASLITNVSFTGQRILTYDMTQKSTAGSECPTLERESHSSDLLGDQKTSPFKEVDEFVLTLVCKDGIQGSIRRWNYFACEQLLVYDIEKFRWCHNVKRFHKSNNIIIVVDLKEEVWYQKCHDPECRRQNYRSSSFPLPQEVCMSHLLMEDEEDQAYLTDELGNIELAVTAPAESTSTTPSEDTEGWGDWPDDPAYLRALQEVEEEEEDEDEEVPDELLLQAVNECE