Protein
Probable proteasome subunit beta type-1
Organism
Encephalitozoon cuniculi (strain GB-M1)
Function
The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity (By similarity).
Similarity
Belongs to the peptidase T1B family.
Sequence
MMSNEKEMTGTTIIAIKYDDGVLIGADSRTSMGAYVSSRVTDKLTQITDKIFVCRSGSSADTQMISSYLRMYLSMYSQLEDSIPQVQRAAALASKIIYENPSLLAGLIVAGYDDKPRVFNISLGGSLTERDWAIGGSGSAFIYGYCDVNWRSGMSLEEGIRFVRNAVSCAINRDNASGGCIRMSAISRTGVQRYFYPGDKVLQ