Protein
Peroxiredoxin-5, mitochondrial
Function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.
Similarity
Belongs to the peroxiredoxin family. Prx5 subfamily.
Sequence
MRLGWLRVLGCRPGSVVSRATIVEGASTTAAGTRGCLEGILEWTFGGVRGFRSAAVAMAPIKVGDAIPSVEVFEKEPGNKVNLAELFKGKKGVLFGLPGAFTPGCSKTHLPGFVEQADALKAKGIQVVACLTVNDVFVTEEWARAHKAEGKVRLLADPSGTFGKETDLLLDDSLLFLFGNHRLKRFSMVIEDGIVKSLNVEPDGTGLTCSLAPNILSQL